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Information on EC 3.1.4.41 - sphingomyelin phosphodiesterase D
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3.1.4.41 sphingomyelin phosphodiesterase DIUBMB Comments
Does not act on phosphatidylcholine, but hydrolyses 2-lysophosphatidylcholine to choline and 2-lysophosphatidate.
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Word Map
- 3.1.4.41
- spider
- loxosceles
-
dermonecrosis
- smases
-
envenom
- laeta
- intermedia
-
bite
- reclusa
- damselae
- sphingomyelinases
-
photobacterium
- gaucho
- sicarius
- antivenoms
-
arachnid
-
phospholipase-d
- medicine
- biotechnology
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
smase d, sphingomyelinase d, glycerophosphoryl diester phosphodiesterase, smased, damselysin, lgrec1, sphingomyelinase-d, phospholipase d 1, sphingomyelin-specific phospholipase d, llpld1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
damselysin
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-
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phospholipase D
PLD
SMase
SMase D
Smase D 1
Smase D 2
SMase I
SMase P1
SMase-C
SMase-D
SMaseD
SMD
sphingomyelase D
sphingomyelin phosphodiesterase D
sphingomyelin-specific phospholipase D
sphingomyelinase
sphingomyelinase D
sphingomyelinase D 1
sphingomyelinase D 2
sphingomyelinase-D
SMD
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-
-
-
sphingomyelinase D
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-
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-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
sphingomyelin + H2O = ceramide phosphate + choline
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-
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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-
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-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
sphingomyelin ceramide-phosphohydrolase
Does not act on phosphatidylcholine, but hydrolyses 2-lysophosphatidylcholine to choline and 2-lysophosphatidate.
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CAS REGISTRY NUMBER
COMMENTARY
54992-31-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-octanoyl-2-hydroxy-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-2,3-cyclic-phosphate + choline
1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-2,3-cyclic-phosphate + choline
2-lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
-
-
-
?
N-lauroyl-D-erythro-sphingosylphosphorylcholine + H2O
lauroyl ceramide-1-phosphate + choline
-
-
-
-
?
trinitrophenylaminolauric acid sphingomyelin + H2O
?
-
-
-
?
trinitrophenylaminolauric acid sphingomyelin + H2O
choline + ?
colour reaction for analysis of sphingomyelinase activity
-
-
?
1-O-hexadecylglycero-3-phosphocholine + H2O
choline + 1-O-hexadecylglycero-3-phosphate
-
i.e. lyso-platelet-activating factor
-
?
1-O-hexadecylglycero-3-phosphocholine + H2O
choline + 1-O-hexadecylglycero-3-phosphate
-
i.e. lyso-platelet-activating factor
-
?
1-octanoyl-2-hydroxy-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-2,3-cyclic-phosphate + choline
Loxosceles whole venoms cleanly convert 8:0 LPC substrate to 8:0 CPA product
-
-
?
1-octanoyl-2-hydroxy-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-2,3-cyclic-phosphate + choline
-
Loxosceles whole venoms cleanly convert 8:0 LPC substrate to 8:0 CPA product
-
-
?
1-octanoyl-2-hydroxy-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-2,3-cyclic-phosphate + choline
-
Loxosceles whole venoms cleanly convert 8:0 LPC substrate to 8:0 CPA product
-
-
?
1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-2,3-cyclic-phosphate + choline
Loxosceles whole venoms and recombinant enzyme
-
-
?
1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-2,3-cyclic-phosphate + choline
-
Loxosceles whole venoms and recombinant enzyme
-
-
?
1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-2,3-cyclic-phosphate + choline
-
Loxosceles whole venoms and recombinant enzyme
-
-
?
2-lysophosphatidylcholine + H2O
2-lysophosphatidate + choline
-
-
-
?
2-lysophosphatidylcholine + H2O
2-lysophosphatidate + choline
-
-
-
-
?
2-lysophosphatidylcholine + H2O
2-lysophosphatidate + choline
-
-
-
?
2-lysophosphatidylcholine + H2O
2-lysophosphatidate + choline
-
-
-
-
?
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
-
-
-
-
ir
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
-
-
-
?
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
-
-
-
-
?
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
-
-
-
-
ir
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
-
albumin-bound
-
?
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
-
-
-
?
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
-
-
-
-
ir
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
-
-
-
-
ir
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
-
-
-
-
?
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
-
-
-
-
ir
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
-
-
-
?
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
-
-
-
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ir
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
-
-
-
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ir
phosphatidylcholine + H2O
phosphatidic acid + choline
-
no activity in presence of Mg2+
-
-
?
phosphatidylcholine + H2O
phosphatidic acid + choline
-
no activity in presence of Mg2+
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-
?
sphingomyelin + H2O
ceramide 1-phosphate + choline
-
-
-
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?
sphingomyelin + H2O
ceramide 1-phosphate + choline
-
-
-
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ir
sphingomyelin + H2O
ceramide 1-phosphate + choline
-
the enzyme shows a marked preference for sphingomyelin over lysophosphatidylcholine
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-
?
sphingomyelin + H2O
ceramide 1-phosphate + choline
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-
-
-
?
sphingomyelin + H2O
ceramide 1-phosphate + choline
-
-
-
-
?
sphingomyelin + H2O
ceramide 1-phosphate + choline
-
substrate as sphingomyelin/cholesterol multilamellar liposomes in a molar ratio of 2:1
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-
?
sphingomyelin + H2O
ceramide 1-phosphate + choline
-
substrate as sphingomyelin/cholesterol multilamellar liposomes in a molar ratio of 2:1
-
-
?
sphingomyelin + H2O
ceramide 1-phosphate + choline
-
the enzyme shows a marked preference for sphingomyelin over lysophosphatidylcholine
-
-
?
sphingomyelin + H2O
ceramide 1-phosphate + choline
-
substrate as sphingomyelin/cholesterol multilamellar liposomes in a molar ratio of 2:1
-
-
?
sphingomyelin + H2O
ceramide 1-phosphate + choline
-
substrate as sphingomyelin/cholesterol multilamellar liposomes in a molar ratio of 2:1
-
-
?
sphingomyelin + H2O
ceramide 1-phosphate + choline
-
-
-
-
ir
sphingomyelin + H2O
ceramide phosphate + choline
-
-
-
?
sphingomyelin + H2O
ceramide phosphate + choline
-
-
-
?