Information on EC 6.3.1.21 - phosphoribosylglycinamide formyltransferase 2

for references in articles please use BRENDA:EC6.3.1.21
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
Two enzymes are known to catalyse the third step in de novo purine biosynthesis. This enzyme requires ATP and utilizes formate, which is provided by the hydrolysis of 10-formyltetrahydrofolate by EC 3.5.1.10, formyltetrahydrofolate deformylase. The other enzyme, EC 2.1.2.2, phosphoribosylglycinamide formyltransferase 1, utilizes 10-formyltetrahydrofolate directly. Formyl phosphate is formed during catalysis as an intermediate. The enzyme from the bacterium Escherichia coli can also catalyse the activity of EC 2.7.2.1, acetate kinase.
Specify your search results
Select one or more organisms in this record: ?
Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
+
N1-(5-phospho-beta-D-ribosyl)glycinamide
=
+
+
N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide
Synonyms
5'-phosphoribosylglycinamide transformylase 2, formate-dependent GAR transformylase, GAR transformylase, GAR transformylase 2, GAR transformylase T, GART2, glycinamide ribonucleotide transformylase, glycinamide ribonucleotide transformylase 2, glycinamide-RNase-transformylase T, non-folate glycinamide ribonucleotide transformylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + formate + N1-(5-phospho-beta-D-ribosyl)glycinamide = ADP + phosphate + N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide
show the reaction diagram
Select items on the left to see more content.