Ligand formic acid

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Basic Ligand Information

Molecular Structure
Picture of formic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
CH2O2
formic acid
BDAGIHXWWSANSR-UHFFFAOYSA-N
Synonyms:
Ameisensäure, formate, HCO2-, HCOO-, HCOOH
Pathway Source
Pathways
MetaCyc
3-hydroxy-4-methyl-anthranilate biosynthesis I, 3-hydroxy-4-methyl-anthranilate biosynthesis II, 3-hydroxyquinaldate biosynthesis, 3-methylthiopropanoate biosynthesis, 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis more


Show all pahtways known for Show all BRENDA pathways known for formic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (30 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
formate + NAD(P)H + O2 = ?
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formate + NADP+ = CO2 + NADPH
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formate + 2 NAD+ + 2 oxidized ferredoxin iron-sulfur cluster = CO2 + 2 NADH + 2 reduced ferredoxin iron-sulfur cluster
show the reaction diagram
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nucleoside 5'-triphosphate + formate = 2'-deoxynucleoside 5'-triphosphate + H2O
show the reaction diagram
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formate + oxidized coenzyme F420 = CO2 + reduced coenzyme F420
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formate + methanol = formaldehyde
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ATP + formate = ADP + formyl phosphate
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formate + acetaldehyde = lactate
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ATP + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = ADP + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (127 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
formaldehyde + O2 = formic acid + H2O2
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2-hydroxyethylphosphonate + O2 = hydroxymethylphosphonate + formate
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7,8-dihydroneopterin + O2 = 7,8-dihydroxanthopterin + formate + glycolaldehyde
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2,5-dihydroxypyridine + O2 + H2O = maleamate + formate
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estriol + 6 reduced ferredoxin [iron-sulfur] cluster + 6 H+ + 3 O2 = ? + formate + 6 oxidized ferredoxin [iron-sulfur] cluster + 4 H2O
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Latia luciferin + AH2 + O2 = oxidized Latia luciferin + CO2 + formate + A + H2O + hnu
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CO2 + NADPH = formate + NADP+
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CO2 + NADH = formate + NAD+
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formaldehyde + NAD+ + H2O = formate + NADH
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formaldehyde + ferricytochrome b559/569 complex = formate + ferrocytochrome b559/569 complex
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formaldehyde + H2O + oxidized ferredoxin = formate + H+ + reduced ferredoxin
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formaldehyde + H2O + oxidized ferredoxin = formate + H+ + reduced ferredoxin
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glycine + 2 H2O + O2 = 2 formic acid + NH3 + H2O2
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CO2 + reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = formate + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
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formyl-CoA + oxalate = formate + oxalyl-CoA
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S-formylglutathione + H2O = glutathione + formate
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10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate
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2-amino-5-formylamino-6-(D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H2O = 2,5-diamino-6-(D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate
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N-formylmaleamic acid + H2O = maleamate + formate
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formamide + H2O = formate + NH3
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N,N-dimethylformamide + H2O = dimethylamine + formate
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N-formyl-L-glutamate + H2O = formate + L-glutamate
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N-benzylformamide + H2O = formate + benzylamine
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4-deoxy-4-formamido-beta-L-arabinopyranosyl undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinose-undecaprenyl phosphate + formate
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N-formimidoyl-L-glutamate + H2O = formate + ammonium + glutamate
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GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + formate + diphosphate
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2,3-dihydro-2,3-dihydroxybenzoyl-CoA + H2O = 3,4-dehydroadipyl-CoA semialdehyde + formate
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5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine + reduced acceptor = 5-hydroxybenzimidazole + 5'-deoxyadenosine + L-methionine + formate + NH3 + phosphate + oxidized acceptor
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (119 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
formate = H2 + CO2
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formate + NAD(P)H + O2 = ?
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formate + 2 NAD+ + 2 oxidized ferredoxin iron-sulfur cluster = CO2 + 2 NADH + 2 reduced ferredoxin iron-sulfur cluster
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nucleoside 5'-triphosphate + formate = 2'-deoxynucleoside 5'-triphosphate + H2O
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formate + NADH = methanal + NAD+
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formate + ferricytochrome b = CO2 + ferrocytochrome b
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formate + O2 = CO2 + H2O2
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Formate + oxidized acceptor = ?
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formate + methanol = formaldehyde
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ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate
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ATP + formate = ADP + formyl phosphate
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ATP + NH3 + formate = ADP + ?
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succinyl-CoA + formate = formyl-CoA + succinate
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formate + acetoacetyl-CoA = formyl-CoA + acetoacetate
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Formate + D-Met = N-Formyl-D-Met + H2O
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formate + acetaldehyde = lactate
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ATP + formate + CoA = AMP + diphosphate + formyl-CoA
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ATP + formate + dihydrofolate = ADP + phosphate + 10-formyldihydrofolate
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ATP + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = ADP + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1242 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
methanol + 2 NAD+ + H2o = formic acid + 2 NADH + 2 H+
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S-hydroxymethylmycothiol + NAD+ = formic acid + mycothiol + NADH + ?
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formaldehyde + acceptor + H2O = formate + reduced acceptor
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5-nitrobenzodioxole + H2O2 = 4-nitrocatechol + formic acid + H2O
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7,8-dihydroneopterin + O2 = 7,8-dihydroxanthopterin + formate + glycolaldehyde
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2,5-dihydroxypyridine + O2 + H2O = maleamate + formate
show the reaction diagram
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trichloroethylene + O2 + NADPH = formate + glyoxylate + NADP+
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CO2 + NADPH = formate + NADP+
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CO2 + reduced benzyl viologen = formate + benzyl viologen
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formaldehyde + NAD+ + H2O = formate + NADH
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formaldehyde + NAD+ + H2O = formate + NADH
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formaldehyde + NAD+ + H2O = formate + NADH + H+
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formaldehyde + NADP+ + H2O = formate + NADPH + H+
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formaldehyde + NADP+ + H2O = formate + NADPH + H+
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formaldehyde + NAD+ + H2O = formate + NADH + H+
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formaldehyde + NAD+ + H2O = formate + NADH
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2 CO2 + NADPH + H+ + 2 reduced ferredoxin [iron-sulfur] cluster = 2 formate + NADP+ + 2 oxidized ferredoxin [iron-sulfur] cluster
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formaldehyde + H2O + O2 = formate + H2O2
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formaldehyde + H2O + benzylviologen = formate + reduced benzylviologen
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formaldehyde + 2,6-dichlorophenolindophenol + H2O = formate + reduced 2,6-dichlorophenolindophenol
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glycine + 2 H2O + O2 = 2 formic acid + NH3 + H2O2
show the reaction diagram
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CO2 + reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = formate + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
show the reaction diagram
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formyl-CoA + oxalate = formate + oxalyl-CoA
show the reaction diagram
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phenyl formate + H2O = phenol + formate
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4-nitrophenyl formate + H2O = 4-nitrophenol + formate
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S-formylglutathione + H2O = formate + glutathione
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4-nitrophenyl formate + H2O = 4-nitrophenol + formate
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formylthiocholine + H2O = thiocholine + formate
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S-formylglutathione + H2O = formate + glutathione
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2,3-diketo-1-phosphohexane + H2O = 2-ketopentanoate + formate + glyoxylate + butyrate
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10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate
show the reaction diagram
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2-amino-5-formylamino-6-(D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H2O = 2,5-diamino-6-(D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate
show the reaction diagram
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N-formylmaleamic acid + H2O = maleamate + formate
show the reaction diagram
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N-formyl aspartic acid + H2O = formate + aspartate
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N-formyl-L-methionine + H2O = L-methionine + formate
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N6-formyl-L-lysine + H2O = L-lysine + formate
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N-formyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + formate
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formamide + H2O = formate + NH3
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formamide + H2O = formate + NH3
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N-formyl-L-glutamate + H2O = formate + L-glutamate
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N-Formyl-D-Glu + H2O = Formate + D-Glu
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N-Formyl-D-Asp + H2O = Formate + D-Asp
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N-formyl-L-methionine + H2O = L-methionine + HCOOH
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