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Information on EC 6.2.1.7 - cholate-CoA ligase

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.7 cholate-CoA ligase
IUBMB Comments
Requires Mg2+ for activity. The mammalian enzyme is membrane-bound and catalyses the first step in the conjugation of bile acids with amino acids, converting bile acids into their acyl-CoA thioesters. Chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate can also act as substrates . The bacterial enzyme is soluble and participates in an anaerobic bile acid 7 alpha-dehydroxylation pathway .
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
choloyl-coa synthetase, bile acid:coa ligase, cholic acid:coa ligase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA
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