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Literature summary for 6.2.1.7 extracted from

  • Mallonee, D.H.; Adams, J.L.; Hylemon, P.B.
    The bile acid-inducible baiB gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A ligase (1992), J. Bacteriol., 174, 2065-2071.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.2.1.7

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Eubacterium sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.022
-
 cholate
-
 Eubacterium sp.
0.2
-
 ATP
-
 Eubacterium sp.

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Eubacterium sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58294
-
 2 * 58294, calculation from nucleotide sequence Eubacterium sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + cholate + CoA Eubacterium sp. initial step in the bile acid 7alpha-dehydroxylation pathway AMP + diphosphate + choloyl-CoA
-
 ?
ATP + cholate + CoA Eubacterium sp. VPI 12708 initial step in the bile acid 7alpha-dehydroxylation pathway AMP + diphosphate + choloyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Eubacterium sp.
-
-
-
Eubacterium sp. VPI 12708
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + chenodeoxycholate + CoA
-
 Eubacterium sp. AMP + diphosphate + chenodeoxycholoyl-CoA
-
 ?
ATP + chenodeoxycholate + CoA
-
 Eubacterium sp. VPI 12708 AMP + diphosphate + chenodeoxycholoyl-CoA
-
 ?
ATP + cholate + CoA
-
 Eubacterium sp. AMP + diphosphate + choloyl-CoA
-
 ?
ATP + cholate + CoA initial step in the bile acid 7alpha-dehydroxylation pathway Eubacterium sp. AMP + diphosphate + choloyl-CoA
-
 ?
ATP + cholate + CoA
-
 Eubacterium sp. VPI 12708 AMP + diphosphate + choloyl-CoA
-
 ?
ATP + cholate + CoA initial step in the bile acid 7alpha-dehydroxylation pathway Eubacterium sp. VPI 12708 AMP + diphosphate + choloyl-CoA
-
 ?
ATP + deoxycholate + CoA
-
 Eubacterium sp. AMP + diphosphate + deoxycholoyl-CoA
-
 ?
ATP + deoxycholate + CoA
-
 Eubacterium sp. VPI 12708 AMP + diphosphate + deoxycholoyl-CoA
-
 ?
additional information the enzyme requires a C-24 bile acid with a free carboxyl group Eubacterium sp. ?
-
 ?
additional information the enzyme requires a C-24 bile acid with a free carboxyl group Eubacterium sp. VPI 12708 ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 58294, calculation from nucleotide sequence Eubacterium sp.