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Literature summary for 6.2.1.7 extracted from
- Purification and characterization of a rat liver bile acid coenzyme A ligase from rat liver microsomes (1997), Arch. Biochem. Biophys., 348, 15-24.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid | 0.005 mM, 63% inhibition of the activity with chenodeoxycholate | Rattus norvegicus |  |
| cholic acid | 0.02 mM, 20% inhibition of the activity with chenodeoxycholate | Rattus norvegicus | |
| EDTA | - |
Rattus norvegicus | |
| lithocholic acid | 0.005 mM, 95% inhibition of the activity with chenodeoxycholate | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.018 | - |
chenodeoxycholate | - |
Rattus norvegicus | |
| 0.548 | - |
ATP | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | dependent on | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 65000 | - |
x * 65000, SDS-PAGE | Rattus norvegicus |
| 243000 | - |
gel filtration | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.385 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + chenodeoxycholate + CoA | - |
Rattus norvegicus | AMP + diphosphate + chenodeoxycholoyl-CoA | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 65000, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| bile acid coenzyme A ligase | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 9.6 | pH 8.0: about 75% of maximal activity, pH 9.6: about 75% of maximal activity | Rattus norvegicus |
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Release 2023.1 (January 2023)
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