Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ATP | inhibition above 3 mM | Cavia porcellus | |
Bile acids | conjugated bile acids are less efficient inhibitors than unconjugated bile acids, deoxycholate is the most potent | Cavia porcellus | |
deoxycholate | - |
Cavia porcellus | |
fatty acids | inhibition is not important in vivo owing to the high concentrations required for inhibition | Cavia porcellus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.006 | - |
cholate | - |
Cavia porcellus | |
0.05 | - |
cholate | CoA | Cavia porcellus | |
0.65 | - |
ATP | - |
Cavia porcellus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | membrane | Cavia porcellus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | modest enhancement of activity | Cavia porcellus | |
Fe2+ | modest enhancement of activity | Cavia porcellus | |
Mg2+ | divalent cation required, Mn2+ or Mg2+ most effective | Cavia porcellus | |
Mn2+ | divalent cation required, Mn2+ or Mg2+ are most effective | Cavia porcellus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Cavia porcellus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + cholate + CoA | - |
Cavia porcellus | AMP + diphosphate + choloyl-CoA | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | 7.3 | - |
Cavia porcellus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 8 | 6.0: about 40% of maximal activity, 8.0: about 50% of maximal activity | Cavia porcellus |