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(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate + 2 GSH
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + GSSG + 2 H+
-
-
?
1-bromo-2,4-dinitrobenzene + glutathione
?
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
?
-
-
?
1-fluoro-2,4-dinitrobenzene + glutathione
?
-
-
?
1-iodo-2,4-dinitrobenzene + glutathione
?
-
-
?
allyl isothiocyanate + glutathione
?
-
-
?
benzyl isothiocyanate + glutathione
?
-
-
?
cumene hydroperoxide + 2 GSH
cumene hydroxide + GSSG + H2O
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
?
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate + glutathione
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + glutathione
-
-
-
?
prostaglandin G2
15-hydroperoxyprostaglandin D2
-
-
-
?
Prostaglandin H2
Prostaglandin D2
additional information
?
-
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
-
?
Prostaglandin H2
Prostaglandin D2
-
-
-
?
Prostaglandin H2
Prostaglandin D2
-
-
-
?
Prostaglandin H2
Prostaglandin D2
-
-
-
?
Prostaglandin H2
Prostaglandin D2
-
-
-
-
?
additional information
?
-
-
the enzyme binds all-trans-retinoic acid or 9-cis-retinoic acid and all-trans-retinal or 13-cis-retinal,but not all-trans-retinol
-
-
?
additional information
?
-
-
the enzyme belongs to the lipocalin family, a group of secretory proteins involved in the transport of small lipophilic ligands
-
-
?
additional information
?
-
-
the enzyme belongs to the lipocalin family, a group of secretory proteins involved in the transport of small lipophilic ligands
-
-
?
additional information
?
-
-
key enzyme in sleep regulation
-
-
?
additional information
?
-
-
key enzyme in sleep regulation
-
-
?
additional information
?
-
-
key enzyme in sleep regulation
-
-
?
additional information
?
-
-
the hematopoietic prostaglandin D synthase is the key enzyme for production of the D and J series of prostanoids in the immune system and mast cells
-
-
?
additional information
?
-
-
the lipocalin-type prostaglandin D synthetase is responsible for the biosynthesis of prostaglandin D2 in the central nervous system and the genital organs and is secreted into the cerebrospinal fluid and the seminal plasma as beta-trace that has retinoid binding activity. It is likely that the enzyme is a bifunctional protein that acts as both retinoid transporter and prostaglandin D2-producing enzyme
-
-
?
additional information
?
-
-
glutathione-dependent enzyme is predicted to function somehow in immune and allergic responses
-
-
?
additional information
?
-
-
may be involved in both the maintenance and maturation of the CNS
-
-
?
additional information
?
-
-
the enzyme activity in rat brain exhibits a circadian fluctuation in parallel with the sleep/wake cycle
-
-
?
additional information
?
-
-
increased secretion of prostaglandin D synthase by interleukin-1beta is completely inhibited by prostaglandin E2
-
-
?
additional information
?
-
-
it is proposed that in wild-type vascular smooth muscle cells the enzyme retards cell cycle progression and migration, precluding hyperplasia of the tunica media, and that diabetic cells appear resistant to inhibitory effects of L-PGDS, which may help explain the increased atherosclerosis observed in diabetes
-
-
?
additional information
?
-
-
lipocalin-type prostaglandin synthase-D can stimulate glucose transport approximately 2fold as well as enhance insulin-stimulated glucose transport due to stimulation of insulin-responsive glucose transporter GLUT4 translocation to the plasma membrane. In response to lipocalin-type prostaglandin synthase-D, there is an increase in GLUT1 expression and an increase in hexokinase III expression
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate + 2 GSH
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + GSSG + 2 H+
-
-
?
1-bromo-2,4-dinitrobenzene + glutathione
?
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
?
-
-
?
1-fluoro-2,4-dinitrobenzene + glutathione
?
-
-
?
1-iodo-2,4-dinitrobenzene + glutathione
?
-
-
?
allyl isothiocyanate + glutathione
?
-
-
?
benzyl isothiocyanate + glutathione
?
-
-
?
cumene hydroperoxide + 2 GSH
cumene hydroxide + GSSG + H2O
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate + glutathione
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + glutathione
-
-
-
?
Prostaglandin H2
Prostaglandin D2
-
-
-
-
?
additional information
?
-
additional information
?
-
-
the enzyme belongs to the lipocalin family, a group of secretory proteins involved in the transport of small lipophilic ligands
-
-
?
additional information
?
-
-
the enzyme belongs to the lipocalin family, a group of secretory proteins involved in the transport of small lipophilic ligands
-
-
?
additional information
?
-
-
key enzyme in sleep regulation
-
-
?
additional information
?
-
-
key enzyme in sleep regulation
-
-
?
additional information
?
-
-
key enzyme in sleep regulation
-
-
?
additional information
?
-
-
the hematopoietic prostaglandin D synthase is the key enzyme for production of the D and J series of prostanoids in the immune system and mast cells
-
-
?
additional information
?
-
-
the lipocalin-type prostaglandin D synthetase is responsible for the biosynthesis of prostaglandin D2 in the central nervous system and the genital organs and is secreted into the cerebrospinal fluid and the seminal plasma as beta-trace that has retinoid binding activity. It is likely that the enzyme is a bifunctional protein that acts as both retinoid transporter and prostaglandin D2-producing enzyme
-
-
?
additional information
?
-
-
glutathione-dependent enzyme is predicted to function somehow in immune and allergic responses
-
-
?
additional information
?
-
-
may be involved in both the maintenance and maturation of the CNS
-
-
?
additional information
?
-
-
the enzyme activity in rat brain exhibits a circadian fluctuation in parallel with the sleep/wake cycle
-
-
?
additional information
?
-
-
increased secretion of prostaglandin D synthase by interleukin-1beta is completely inhibited by prostaglandin E2
-
-
?
additional information
?
-
-
it is proposed that in wild-type vascular smooth muscle cells the enzyme retards cell cycle progression and migration, precluding hyperplasia of the tunica media, and that diabetic cells appear resistant to inhibitory effects of L-PGDS, which may help explain the increased atherosclerosis observed in diabetes
-
-
?
additional information
?
-
-
lipocalin-type prostaglandin synthase-D can stimulate glucose transport approximately 2fold as well as enhance insulin-stimulated glucose transport due to stimulation of insulin-responsive glucose transporter GLUT4 translocation to the plasma membrane. In response to lipocalin-type prostaglandin synthase-D, there is an increase in GLUT1 expression and an increase in hexokinase III expression
-
-
?
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Shimizu, T.; Yamamoto, S.; Hayaishi, O.
Purification of PGH-PDG isomerase from rat brain
Methods Enzymol.
86
73-77
1982
Cavia porcellus, Oryctolagus cuniculus, Felis catus, Platyrrhini, Mus musculus, Rattus norvegicus
brenda
Christ-Hazelhof, E.; Nugteren, D.H.
Isolation of PGH-PGS isomerase from rat spleen
Methods Enzymol.
86
77-84
1982
Rattus norvegicus
brenda
Shimizu, T.; Yamamoto, S.; Hayaishi, O.
Purification and properties of prostaglandin D synthetase from rat brain
J. Biol. Chem.
254
5222-5228
1979
Rattus norvegicus
brenda
Toh, H.; Kubodera, H.; Nakajima, N.; Sekiya, T.; Eguchi, N.; Tanaka, T.; Urade, Y.; Hayaishi, O.
Glutathione-independent prostaglandin D synthase as a lead molecule for designing new functional proteins
Protein Eng.
9
1067-1082
1996
Ursus sp., Felis catus, Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus sp.
brenda
Hayaishi, O.; Matsumura, H.; Urade, Y.
Prostaglandin D synthase is the key enzyme in the promotion of physiological sleep
J. Lipid Mediat. Cell Signal.
6
429-431
1993
Homo sapiens, Rattus norvegicus
brenda
Hayaishi, O.
Prostaglandin D synthase, beta-trace and sleep
Recent Adv. Prostaglandin Thromboxane Leukotriene Res.
1998
347-350
1998
Homo sapiens, Rattus norvegicus
-
brenda
Ujihara, M.; Tsuchida, S.; Satoh, K.; Sato, K.; Urade, Y.
Biochemical and immunological demonstration of prostaglandin D2, E2, and F2alpha formation from prostaglandin H2 by various rat glutathione S-transferase isoenzymes
Arch. Biochem. Biophys.
264
428-437
1988
Rattus norvegicus
brenda
Islam, F.; Watanabe, Y.; Morii, H.; Hayaishi, O.
Inhibition of rat brain prostaglandin D synthase by inorganic selenocompounds
Arch. Biochem. Biophys.
289
161-166
1991
Rattus norvegicus
brenda
Islam, F.; Urade, Y.; Watanabe, Y.; Hayaishi, O.
A particle concentration fluorescence immunoassay for prostaglandin D synthase in the rat central nervous system
Arch. Biochem. Biophys.
277
290-295
1990
Rattus norvegicus
brenda
Takahata, R.; Matsumura, H.; Kantha, S.S.; Kubo, E.; Kawase, K.; Sakai, T.; Hayaishi, O.
Intravenous administration of inorganic selenium compounds, inhibitors of prostaglandin D synthase, inhibits sleep in freely moving rats
Brain Res.
623
65-71
1993
Rattus norvegicus
brenda
Gerashchenko, D.Y.; Beuckmann, C.T.; Marcheselli, V.L.; Gordon, W.C.; Kanaoka, Y.; Eguchi, N.; Urade, Y.; Hayaishi, O.; Bazan, N.G.
Localization of lipocalin-type prostaglandin D synthase (beta-trace) in iris ciliary body, and eye fluids
Invest. Ophthalmol. Vis. Sci.
39
198-203
1998
Rattus norvegicus
brenda
Beuckmann, C.T.; Gordon, W.C.; Kanaoka, Y.; Eguchi, N.; Marcheselli, V.L.; Gerashchenko, D.Y.; Urade, Y.; Hayaishi, O.; Bazan, N.G.
Lipocalin-type prostaglandin D synthase (beta-trace) is located in pigment epithelial cells of rat retina and accumulates within interophotoreceptor matrix
J. Neurosci.
16
6119-6124
1996
Rattus norvegicus (P22057)
brenda
Matsumura, H.; Takahata, R.; Hayaishi, O.
Inhibition of sleep in rats by inorganic selenium compounds, inhibitors of prostaglandin D synthase
Proc. Natl. Acad. Sci. USA
88
9046-9050
1991
Rattus norvegicus
brenda
Tanaka, T.; Urade, Y.; Kimura, H.; Eguchi, N.; Nishikawa, A.; Hayaishi, O.
Lipocalin-type prostaglandin D synthase (beta-trace) is a newly recognized type of retinoid transporter
J. Biol. Chem.
272
15789-15795
1997
Rattus norvegicus
brenda
Meyer, D.J.; Thomas, M.
Characterization of rat spleen prostaglandin H D-isomerase as a sigma-class GSH transferase
Biochem. J.
311
739-742
1995
Rattus norvegicus
brenda
Urade, Y.; Watanabe, K.; Hayaishi, O.
Prostaglandin D, E, and F synthases
J. Lipid Mediat. Cell Signal.
12
257-273
1995
Gallus gallus, Homo sapiens, Rattus norvegicus
brenda
Kanaoka, Y.; Ago, H.; Inagaki, E.; Nanayama, T.; Miyano, M.; Kikuno, R.; Eguchi, N.; Toh, H.; Urade, Y.; Hayaishi, O.
Cloning and crystal structure of hematopoietic prostaglandin D synthase
Cell
90
1085-1095
1997
Rattus norvegicus
brenda
Urade, Y.; Nagata, A.; Suzuki, Y.; Fujii, Y.; Hayaishi, O.
Primary structure of rat brain prostaglandin D synthetase deduced from cDNA sequence
J. Biol. Chem.
264
1041-1045
1989
Rattus norvegicus
brenda
Steinhoff, M.M.; Lee, L.H.; Jakschik, B.A.
Enzymatic formation of prostaglandin D2 by rat basophilic leukemia cells and normal rat mast cells
Biochim. Biophys. Acta
618
28-34
1980
Rattus norvegicus
brenda
Jowsey, I.R.; Thomson, A.M.; Flanagan, J.U.; Murdock, P.R.; Moore, G.B.T.; Meyer, D.J.; Murphy, G.J.; Smith, S.A.; Hayes, J.D.
Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases
Biochem. J.
359
507-516
2001
Homo sapiens, Rattus norvegicus (O35543)
brenda
Beuckmann, C.T.; Aoyagi, M.; Okazaki, I.; Hiroike, T.; Toh, H.; Hayaishi, O.; Urade, Y.
Binding of biliverdin, bilirubin, and thyroid hormones to lipocalin-type prostaglandin D synthase
Biochemistry
38
8006-8013
1999
Rattus norvegicus
brenda
Samy, E.T.; Li, J.C.H.; Grima, J.; Lee, W.M.; Silvestrini, B.; Cheng, C.Y.
Sertoli cell prostaglandin D2 synthetase is a multifunctional molecule: its expression and regulation
Endocrinology
141
710-721
2000
Rattus norvegicus
brenda
Pinzar, E.; Miyano, M.; Kanaoka, Y.; Urade, Y.; Hayaishi, O.
Structural basis of hematopoietic prostaglandin D synthase activity elucidated by site-directed mutagenesis
J. Biol. Chem.
275
31239-31244
2000
Rattus norvegicus (O35543)
brenda
Ragolia, L.; Palaia, T.; Koutrouby, T.B.; Maesaka, J.K.
Inhibition of cell cycle progression and migration of vascular smooth muscle cells by prostaglandin D2 synthase: resistance in diabetic Goto-Kakizaki rats
Am. J. Physiol.
287
C1273-1281
2004
Rattus norvegicus
brenda
Nagasaka, T.; Hiraide, M.; Sugimoto, T.; Shindo, K.; Shiozawa, Z.; Yokota, S.
Localization of lipocaline-type prostaglandin D synthase in rat brain: immunoelectron microscopic study
Histochem. Cell Biol.
121
483-491
2004
Rattus norvegicus
brenda
Muraki, T.; Fujimori, K.; Ishizaka, M.; Ohe, Y.; Urade, Y.; Okajima, F.; Ishikawa, K.
Effects of interleukin-1beta and prostaglandin E2 on prostaglandin D synthase production in cultivated rat leptomeningeal cells
J. Cereb. Blood Flow Metab.
24
409-418
2004
Rattus norvegicus
brenda
Kengni, J.H.; St-Louis, I.; Parent, S.; Leblanc, V.; Shooner, C.; Asselin, E.
Regulation of prostaglandin D synthase and prostacyclin synthase in the endometrium of cyclic, pregnant, and pseudopregnant rats and their regulation by sex steroids
J. Endocrinol.
195
301-311
2007
Rattus norvegicus
brenda
Ragolia, L.; Hall, C.E.; Palaia, T.
Post-translational modification regulates prostaglandin D2 synthase apoptotic activity: characterization by site-directed mutagenesis
Prostaglandins Other Lipid Mediat.
83
25-32
2007
Rattus norvegicus
brenda
Liu, J.; Lin, K.; Guo, C.; Gao, H.; Yao, Y.; Lin, D.
Expression and purification of cysteine mutation isoforms of rat lipocalin-type prostaglandin D synthase for nuclear magnetic resonance study
Acta Biochim. Biophys. Sin.
40
489-496
2008
Rattus norvegicus
brenda
Liu, J.; Guo, C.; Yao, Y.; Lin, D.
Effects of removing a conserved disulfide bond on the biological characteristics of rat lipocalin-type prostaglandin D synthase
Biochimie
90
1637-1646
2008
Rattus norvegicus
brenda
Ragolia, L.; Hall, C.E.; Palaia, T.
Lipocalin-type prostaglandin D(2) synthase stimulates glucose transport via enhanced GLUT4 translocation
Prostaglandins Other Lipid Mediat.
87
34-41
2008
Mus musculus, Rattus norvegicus
brenda
Gao, W.; Schmidtko, A.; Wobst, I.; Lu, R.; Angioni, C.; Geisslinger, G.
Prostaglandin D2 produced by hematopoietic prostaglandin D synthase contributes to LPS-induced fever
J. Physiol. Pharmacol.
60(2)
145-150
2009
Rattus norvegicus
brenda