Literature summary for 5.3.99.2 extracted from

Ragolia, L.; Hall, C.E.; Palaia, T.
Post-translational modification regulates prostaglandin D2 synthase apoptotic activity: characterization by site-directed mutagenesis (2007), Prostaglandins Other Lipid Mediat., 83, 25-32.

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Protein Variants

Protein Variants	Comment	Organism
A106S	creation of a new protein kinase C phosphorylation site, significant inhibition of the ability of enzyme to induce apoptosis and significant decrease in catalytic activity	Rattus norvegicus
C65A	mutation of active site, significant inhibition of the ability of enzyme to induce apoptosis and significant decrease in catalytic activity	Rattus norvegicus
D51A	creation of new glycosylation site 1, significant inhibition of the ability of enzyme to induce apoptosis and significant decrease in catalytic activity	Rattus norvegicus
D78A	creation of new glycosylation site 2, no significant changes in enzyme activity or ability to induce apoptosis	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
vascular smooth muscle cell	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)