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Literature summary for 5.3.99.2 extracted from

  • Gao, W.; Schmidtko, A.; Wobst, I.; Lu, R.; Angioni, C.; Geisslinger, G.
    Prostaglandin D2 produced by hematopoietic prostaglandin D synthase contributes to LPS-induced fever (2009), J. Physiol. Pharmacol., 60(2), 145-150.
    View publication on PubMed
Search for more literature for 5.3.99.2

Application

Application Comment Organism
medicine prostaglandin D2 produced by hematopoietic prostaglandin D synthase contributes to lipopolysaccharide-induced fever Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
EDJ300520
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Prostaglandin H2 Rattus norvegicus
-
 Prostaglandin D2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
 Rattus norvegicus Prostaglandin D2
-
 ?

Synonyms

Synonyms Comment Organism
H-PGDS
-
 Rattus norvegicus
Hematopoietic prostaglandin D synthase
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus oral pretreatment with the inhibitor EDJ300520 prevents the lipopolysaccharide-induced PGD2 increase in plasma and lungs down
Rattus norvegicus the synthesis of PGD2 is increased in plasma and lungs in response to systemic lipopolysaccharide injection up