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Literature summary for 5.3.99.2 extracted from

  • Jowsey, I.R.; Thomson, A.M.; Flanagan, J.U.; Murdock, P.R.; Moore, G.B.T.; Meyer, D.J.; Murphy, G.J.; Smith, S.A.; Hayes, J.D.
    Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases (2001), Biochem. J., 359, 507-516.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of cDNA in Escherichia coli Homo sapiens
expression of cDNA in Escherichia coli Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.2
-
glutathione
-
Homo sapiens
0.2
-
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
Homo sapiens
0.2
-
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
Rattus norvegicus
0.3
-
glutathione
-
Rattus norvegicus
0.3
-
glutathione glutathione S-transferase activity Rattus norvegicus
3.2
-
1-chloro-2,4-dinitrobenzene
-
Homo sapiens
5
-
1-chloro-2,4-dinitrobenzene
-
Rattus norvegicus
8
-
glutathione glutathione S-transferase activity Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
23000
-
x * 23000, SDS-PAGE Homo sapiens
23000
-
x * 23000, SDS-PAGE Rattus norvegicus
23298
-
x * 23298, deduced from nucleotide sequence Rattus norvegicus
23359
-
x * 23359, deduced from nucleotide sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Homo sapiens
-
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Rattus norvegicus
-
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
?
1-bromo-2,4-dinitrobenzene + glutathione Homo sapiens
-
?
-
?
1-bromo-2,4-dinitrobenzene + glutathione Rattus norvegicus
-
?
-
?
1-chloro-2,4-dinitrobenzene + glutathione Homo sapiens
-
?
-
?
1-chloro-2,4-dinitrobenzene + glutathione Rattus norvegicus
-
?
-
?
1-fluoro-2,4-dinitrobenzene + glutathione Homo sapiens
-
?
-
?
1-fluoro-2,4-dinitrobenzene + glutathione Rattus norvegicus
-
?
-
?
1-iodo-2,4-dinitrobenzene + glutathione Homo sapiens
-
?
-
?
1-iodo-2,4-dinitrobenzene + glutathione Rattus norvegicus
-
?
-
?
allyl isothiocyanate + glutathione Homo sapiens
-
?
-
?
allyl isothiocyanate + glutathione Rattus norvegicus
-
?
-
?
benzyl isothiocyanate + glutathione Homo sapiens
-
?
-
?
benzyl isothiocyanate + glutathione Rattus norvegicus
-
?
-
?
cumene hydroperoxide + 2 GSH Homo sapiens
-
cumene hydroxide + GSSG + H2O
-
?
cumene hydroperoxide + 2 GSH Rattus norvegicus
-
cumene hydroxide + GSSG + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus O35543
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant PGDS Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
Homo sapiens (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
Rattus norvegicus (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
?
1-bromo-2,4-dinitrobenzene + glutathione
-
Homo sapiens ?
-
?
1-bromo-2,4-dinitrobenzene + glutathione
-
Rattus norvegicus ?
-
?
1-chloro-2,4-dinitrobenzene + glutathione
-
Homo sapiens ?
-
?
1-chloro-2,4-dinitrobenzene + glutathione
-
Rattus norvegicus ?
-
?
1-fluoro-2,4-dinitrobenzene + glutathione
-
Homo sapiens ?
-
?
1-fluoro-2,4-dinitrobenzene + glutathione
-
Rattus norvegicus ?
-
?
1-iodo-2,4-dinitrobenzene + glutathione
-
Homo sapiens ?
-
?
1-iodo-2,4-dinitrobenzene + glutathione
-
Rattus norvegicus ?
-
?
allyl isothiocyanate + glutathione
-
Homo sapiens ?
-
?
allyl isothiocyanate + glutathione
-
Rattus norvegicus ?
-
?
benzyl isothiocyanate + glutathione
-
Homo sapiens ?
-
?
benzyl isothiocyanate + glutathione
-
Rattus norvegicus ?
-
?
cumene hydroperoxide + 2 GSH
-
Homo sapiens cumene hydroxide + GSSG + H2O
-
?
cumene hydroperoxide + 2 GSH
-
Rattus norvegicus cumene hydroxide + GSSG + H2O
-
?

Subunits

Subunits Comment Organism
? x * 23000, SDS-PAGE Homo sapiens
? x * 23000, SDS-PAGE Rattus norvegicus
? x * 23298, deduced from nucleotide sequence Rattus norvegicus
? x * 23359, deduced from nucleotide sequence Homo sapiens

Synonyms

Synonyms Comment Organism
glutathione-dependent prostaglandin D2 synthase
-
Homo sapiens
glutathione-dependent prostaglandin D2 synthase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
glutathione
-
Homo sapiens
glutathione
-
Rattus norvegicus