We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Information on EC 5.2.1.2 - maleylacetoacetate isomerase for references in articles please use BRENDA:EC5.2.1.2Word Map on EC 5.2.1.2
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
maleylacetoacetate isomerase
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
4-Maleylacetoacetate = 4-fumarylacetoacetate
4-Maleylacetoacetate = 4-fumarylacetoacetate
mechanism, preferred binding order is maleylacetone followed by glutathione
-
4-Maleylacetoacetate = 4-fumarylacetoacetate
ordered sequence of binding: maleylacetone first followed by glutathione
-
4-Maleylacetoacetate = 4-fumarylacetoacetate
tyrosine degradation leads to the formation of homogentisate, maleylacetoacetate isomerase, homogentisate dioxygenase and fumarylacetoacetate hydrolase are expressed in Arabidopsis thaliana to generate fumarate and acetoacetate
4-Maleylacetoacetate = 4-fumarylacetoacetate
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
cis-trans-isomerization
-
cis-trans-isomerization
-
-
cis-trans-isomerization
-
-
double bond
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
L-tyrosine degradation I
-
-
Microbial metabolism in diverse environments
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
4-maleylacetoacetate cis-trans-isomerase
Also acts on maleylpyruvate.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
glutathione S-transferase Zeta 1-1
-
-
glutathione S-transferase zeta-class 1
-
glutathione S-transferase zeta/maleylacetoacetate isomerase
-
-
glutathione transferase zeta
-
-
glutathione transferase zeta 1/maleylacetoacetate isomerase
-
-
Isomerase, maleylacetoacetate
-
-
-
-
maleylacetoacetate isomerase
Maleylacetoacetic isomerase
-
-
-
-
Maleylacetone cis-trans-isomerase
-
-
-
-
Maleylacetone isomerase
-
-
-
-
GSTZ1-1
-
-
MAAI
-
-
-
-
maleylacetoacetate isomerase
-
maleylacetoacetate isomerase
-
bifunctional enzyme EC 2.5.1.18, glutathione transferase Zeta, GSTZ1-1
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
SWISSPROT
brenda
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
strain 01
-
-
brenda
-
-
-
brenda
-
SwissProt
brenda
-
-
-
brenda
-
SwissProt
brenda
-
-
-
brenda
strain 01
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
malfunction
-
human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate, GSTz1/MAAI haplotype significantly affects the kinetics and biotransformation of dichloroacetate. GSTz1/MAAI variants associated with the slowest rates of dichlorocacetate metabolism induce structural changes in the enzyme homodimer, predicting protein instability or abnormal protein-protein interactions. Enzyme inhibition also results in the accumulation of the potentially hepatotoxic tyrosine intermediates maleylacetoacetate and maleylacetone and of delta-aminolevulinate
metabolism
-
catalyses a significant step in the catabolism of phenylalanine and tyrosine
metabolism
-
the bifunctional enzyme glutathione transferase zeta/maleylacetoacetate isomerase is the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid + glutathione
2-(glutathion-S-yl)-3-(4-nitrophenyl)propanoic acid
4-maleylacetoacetate
4-fumarylacetoacetate
6-Oxo-2(E),4(Z)-heptanedienoic acid
6-Oxo-2(Z),4(E)-heptanedienoic acid
chlorofluoroacetic acid + ?
glyoxylate + ?
-
activity assay
-
-
?
cis-beta-Acetylacrylate
trans-beta-Acetylacrylate
Maleylacetoacetate
Fumarylacetoacetate
Maleylpyruvate
Fumarylpyruvate
Monomethyl 2(Z),4(E)-muconate
Monomethyl 2(E),4(E)-muconate
-
+ GSH
-
-
Monomethyl 5-oxo-1(E),3(Z)-hexadien-1-ylphosphonate monoanion
Monomethyl 5-oxo-1(Z),3(E)-hexadien-1-ylphosphonate monoanion
-
cis-trans double isomerization
-
-
additional information
?
-
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid + glutathione
2-(glutathion-S-yl)-3-(4-nitrophenyl)propanoic acid
-
it is proposed that the charged side chain of Arg-175 forms a salt bridge with the carboxylate of the alpha-halo acid substrates
-
?
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid + glutathione
2-(glutathion-S-yl)-3-(4-nitrophenyl)propanoic acid
-
-
-
-
-
4-maleylacetoacetate
4-fumarylacetoacetate
-
-
-
?
4-maleylacetoacetate
4-fumarylacetoacetate
-
-
-
?
4-maleylacetoacetate
4-fumarylacetoacetate
-
-
-
?
4-maleylacetoacetate
4-fumarylacetoacetate
-
-
-
-
?
6-Oxo-2(E),4(Z)-heptanedienoic acid
6-Oxo-2(Z),4(E)-heptanedienoic acid
-
-
-
-
6-Oxo-2(E),4(Z)-heptanedienoic acid
6-Oxo-2(Z),4(E)-heptanedienoic acid
-
cis-trans double isomerization
-
-
6-Oxo-2(E),4(Z)-heptanedienoic acid
6-Oxo-2(Z),4(E)-heptanedienoic acid
-
r, reverse reaction is catalyzed in presence of GSH
-
-
6-Oxo-2(E),4(Z)-heptanedienoic acid
6-Oxo-2(Z),4(E)-heptanedienoic acid
-
cis-trans double isomerization
-
-
6-Oxo-2(E),4(Z)-heptanedienoic acid
6-Oxo-2(Z),4(E)-heptanedienoic acid
-
r, reverse reaction is catalyzed in presence of GSH
-
-
cis-beta-Acetylacrylate
trans-beta-Acetylacrylate
-
-
-
-
cis-beta-Acetylacrylate
trans-beta-Acetylacrylate
-
-
-
-
Maleylacetoacetate
?
enzyme of the phenylacetate pathway
-
-
-
Maleylacetoacetate
?
human maleylacetoacetate isomerase deficiency presumably causes tyrosinemia that can be characterized by the absence of succinylacetone
-
-
-
Maleylacetoacetate
?
-
enzyme of the tyrosine-catabolism
-
-
-
Maleylacetoacetate
?
-
enzyme of the tyrosine-catabolism
-
-
-
Maleylacetoacetate
?
-
enzymatic isomerization of cis,cis-muconaldehydic acid to trans,trans-muconaldehydic acid followed by the oxidation is suggested to be the path to trans,trans-muconate
-
-
-
Maleylacetoacetate
?
-
one of the enzymes responsible for the oxidative metabolism of aromatic amino acids
-
-
-
Maleylacetoacetate
Fumarylacetoacetate
-
-
-
-
Maleylacetoacetate
Fumarylacetoacetate
-
-
-
-
Maleylacetoacetate
Fumarylacetoacetate
-
-
-
-
Maleylacetoacetate
Fumarylacetoacetate
-
-
-
-
Maleylacetoacetate
Fumarylacetoacetate
-
-
-
-
Maleylacetoacetate
Fumarylacetoacetate
-
-
-
-
Maleylacetoacetate
Fumarylacetoacetate
-
-
-
-
-
Maleylacetoacetate
Fumarylacetoacetate
-
+ GSH
+ GSSG
-
Maleylacetoacetate
Fumarylacetoacetate
-
+ GSH
+ GSSG
-
Maleylacetoacetate
Fumarylacetoacetate
-
+ GSH
+ GSSG
-
Maleylacetoacetate
Fumarylacetoacetate
-
+ GSH
+ GSSG
-
Maleylpyruvate
Fumarylpyruvate
-
-
-
?
Maleylpyruvate
Fumarylpyruvate
-
about 20fold higher activity than with maleylacetoacetate
-
-
additional information
?
-
-
enzyme deficiency would presumably cause tyrosinemia that would be characterized by the absence of succinylacetone
-
?
additional information
?
-
enzyme deficiency would presumably cause tyrosinemia that would be characterized by the absence of succinylacetone
-
?
additional information
?
-
-
key enzyme in the metabolic degradation of phenylalanine and tyrosine
-
?
additional information
?
-
-
the enzyme plays an important role in the metabolism of tyrosine
-
?
additional information
?
-
-
the bifunctional enzyme dehalogenates dichloroacetate to glyoxalate via its zeta-1 family glutathione transferase activity. Dichloroacetate is relevant to environmental science and allopathic medicine. The sensitivity to the inhibitor varies between enzyme haplotypes. Three nonsynonymous single-nucleotide polymorphisms of GSTz1/MAAI show different activity toward dichloroacetate and certain other xenobiotic haloacids
-
-
-
additional information
?
-
-
GSTzeta/MAAI is induced during the differentiation of 3T3-L1 fibroblasts into adipocytes. This process requires expression of C/EBPalpha as well as PPARgamma
-
-
-
additional information
?
-
-
the enzyme catalyzes the penultimate step in catabolic pathways for phenylalanine and tyrosine. BABL/c GSTZ1/MAAI-deficient mice show a number of significant abnormalities including altered organ sizes, an abnormal pattern of circulating leukocytes, and the consitutive induction of hepatic alpha, mu and pi class glutathione transferases
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
4-maleylacetoacetate
4-fumarylacetoacetate
-
-
-
-
?
additional information
?
-
Maleylacetoacetate
?
O43123
enzyme of the phenylacetate pathway
-
-
-
Maleylacetoacetate
?
O43708
human maleylacetoacetate isomerase deficiency presumably causes tyrosinemia that can be characterized by the absence of succinylacetone
-
-
-
Maleylacetoacetate
?
-
enzyme of the tyrosine-catabolism
-
-
-
Maleylacetoacetate
?
-
enzyme of the tyrosine-catabolism
-
-
-
Maleylacetoacetate
?
-
enzymatic isomerization of cis,cis-muconaldehydic acid to trans,trans-muconaldehydic acid followed by the oxidation is suggested to be the path to trans,trans-muconate
-
-
-
Maleylacetoacetate
?
-
one of the enzymes responsible for the oxidative metabolism of aromatic amino acids
-
-
-
additional information
?
-
-
enzyme deficiency would presumably cause tyrosinemia that would be characterized by the absence of succinylacetone
-
?
additional information
?
-
O43708
enzyme deficiency would presumably cause tyrosinemia that would be characterized by the absence of succinylacetone
-
?
additional information
?
-
-
key enzyme in the metabolic degradation of phenylalanine and tyrosine
-
?
additional information
?
-
-
the enzyme plays an important role in the metabolism of tyrosine
-
?
additional information
?
-
-
GSTzeta/MAAI is induced during the differentiation of 3T3-L1 fibroblasts into adipocytes. This process requires expression of C/EBPalpha as well as PPARgamma
-
-
-
additional information
?
-
-
the enzyme catalyzes the penultimate step in catabolic pathways for phenylalanine and tyrosine. BABL/c GSTZ1/MAAI-deficient mice show a number of significant abnormalities including altered organ sizes, an abnormal pattern of circulating leukocytes, and the consitutive induction of hepatic alpha, mu and pi class glutathione transferases
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Dichloroacetate
-
the sensitivity to the inhibitor varies between enzyme haplotypes. Three nonsynonymous single-nucleotide polymorphisms of GSTz1/MAAI show different activity toward dichloroacetate and certain other xenobiotic haloacids
Dichloroacetic acid
-
DCA
maleylacetone
-
inhibits isomerization of 6-oxo-2(E),4(Z)-heptanedienoic acid into 6-oxo-2(Z),4(E)-heptanedienoic acid, and the reverse reaction
N-Hexylmaleamic acid
-
noncompetitive towards GSH and maleylacetone
NaBH4
-
inhibition in absence of substrate, increases activity in presence of substrate and GSH
S-Glutathioyl-N-hexylmaleamate
-
competitive towards GSH, uncompetitive towards maleylacetone
NEM
-
biphasic kinetics
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
GSH
-
glutathione-independent
GSH
-
the enzyme binds glutathione through the backbone of the tripeptide
GSH
-
required as coenzyme
GSH
-
other thiols are inactive; required as coenzyme
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.023 - 0.417
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
0.068 - 0.64
4-Maleylacetoacetate
1.9
6-Oxo-2(E),4(Z)-heptanedienoic acid
-
-
3.2
6-Oxo-2(Z),4(E)-heptanedienoic acid
-
-
3
cis-beta-Acetylacrylate
-
-
2.9
trans-beta-Acetylacrylate
-
-
0.023
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, mutant enzyme R175A
0.027
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, mutant enzyme R175K
0.029
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, enzyme hGSTZ1d-1d
0.044
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, enzyme hGSTZ1c-1c
0.096
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, enzyme hGSTZ1b-1b
0.128
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, enzyme hGSTZ1a-1a
0.319
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, mutant enzyme S15A
0.417
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, mutant enzyme C16A
0.068
4-Maleylacetoacetate
-
pH 7.6, 25°C, mutant enzyme C165A
0.223
4-Maleylacetoacetate
-
pH 7.6, 25°C, mutant enzyme R175K
0.368
4-Maleylacetoacetate
-
pH 7.6, 25°C, wild-type enzyme
0.5
4-Maleylacetoacetate
in the presence of 1.2 mM glutathione
0.64
4-Maleylacetoacetate
-
pH 7.6, 25°C, mutant enzyme S15A
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.19 - 6.08
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
2.1 - 464
4-Maleylacetoacetate
additional information
additional information
-
-
-
0.19
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, mutant enzyme R175A
0.55
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, enzyme hGSTZ1d-1d
0.59
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, enzyme hGSTZ1c-1c
0.61
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, mutant enzyme R175K
0.82
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, enzyme hGSTZ1b-1b
1
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, mutant enzyme S15A
1.3
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, enzyme hGSTZ1a-1a
2.55
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, mutant enzyme C16A
6.08
(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
-
pH 7.6, 25°C, enzyme hGSTZ1b-1b; pH 7.6, 25°C, enzyme hGSTZ1c-1c; pH 7.6, 25°C, mutant enzyme R175K
2.1
4-Maleylacetoacetate
-
pH 7.6, 25°C, mutant enzyme S15A
72.6
4-Maleylacetoacetate
-
pH 7.6, 25°C, mutant enzyme S15A
141
4-Maleylacetoacetate
-
pH 7.6, 25°C, mutant enzyme C165A
149
4-Maleylacetoacetate
-
pH 7.6, 25°C, mutant enzyme R175A
368
4-Maleylacetoacetate
-
pH 7.6, 25°C, mutant enzyme R175K
464
4-Maleylacetoacetate
-
pH 7.6, 25°C, wild-type enzyme
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
-
spectrophotometric assay with (+/-)-2-bromo-3-(4-nitrophenyl)propionic acid
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
10.5 - 11
-
reaction with (+/-)-2-bromo-3-(4-nitrophenyl)propionic acid and glutathione
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
6 - 9
-
pH 6.0: about 60% of maximal activity, pH 7.2-8.0: maximal activity
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
GSTzeta/MAAI is induced during the differentiation of 3T3-L1 fibroblasts into adipocytes. This process requires expression of C/EBPalpha as well as PPARgamma
brenda
-
-
brenda
-
-
-
brenda
-
-
brenda
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
33500
-
1 * 33500, SDS-PAGE
50000
dimer, gel filtration
16000
-
x * 16000, SDS-PAGE
16000
-
x * 16000, SDS-PAGE after heating the enzyme at 100°C for 10 min in a standard aqueous medium containing 1% SDS and 8M urea
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dimer
50000, gel filtration
monomer
-
1 * 33500, SDS-PAGE
?
-
x * 16000, SDS-PAGE
?
-
x * 16000, SDS-PAGE after heating the enzyme at 100°C for 10 min in a standard aqueous medium containing 1% SDS and 8M urea; x * 35000, SDS-PAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
hanging drop vapor diffusion method, 1.9 A resolution
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
10-15 mM mercaptoethanol stabilizes
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
of the recombinant protein
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
expression in Escherichia coli
expression in Escherichia coli, his-tagged protein is mainly insoluble
gene GSTz1/MAAI is located on chromosome 14q24.3, genotyping, overview
-
expression in Escherichia coli
expression in Escherichia coli
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
C16A
-
the ratio of turnover number to KM-value for (+/-)-2-bromo-3-(4-nitrophenyl)propionic acid is 2.1fold decreased compared to the wild-type enzyme, the ratio of turnover number to KM-value for 4-maleylacetoacetate is 1.6fold increased compared to wild-type enzyme
R175A
-
the ratio of turnover number to KM-value for (+/-)-2-bromo-3-(4-nitrophenyl)propionic acid is 1.5fold decreased compared to the wild-type enzyme, the ratio of turnover number to KM-value for 4-maleylacetoacetate is 6.8fold decreased compared to wild-type enzyme
R175K
-
the ratio of turnover number to KM-value for (+/-)-2-bromo-3-(4-nitrophenyl)propionic acid is 1.8fold increased compared to the wild-type enzyme, the ratio of turnover number to KM-value for 4-maleylacetoacetate is 1.3fold increased compared to wild-type enzyme
S14A
-
mutant enzyme shows no activity with {(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid} or 4-maleylacetoacetate
S15A
-
the ratio of turnover number to KM-value for (+/-)-2-bromo-3-(4-nitrophenyl)propionic acid is 2.3fold decreased compared to the wild-type enzyme, the ratio of turnover number to KM-value for 4-maleylacetoacetate is 11.8fold decreased compared to wild-type enzyme
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
medicine
-
cis and/or trans isomers of 2,4-dioxohept-2-enoic acid might be diagnostic for human deficiency of maleylacetoacetate isomerase
additional information
-
knowledge of the GSTz1/MAAI haplotype can be used prospectively to identify individuals at potential risk of dichloroacetate’s adverse side effects from environmental or clinical exposure or who may exhibit aberrant amino acid metabolism in response to dietary protein
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Acidosis, Lactic
Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways.
Acidosis, Lactic
Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency.
Acidosis, Lactic
Prenatal and postnatal expression of glutathione transferase ? 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.
Liver Failure
Gene structure, chromosomal location, and expression pattern of maleylacetoacetate isomerase.
Liver Neoplasms
GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate.
maleylacetoacetate isomerase deficiency
Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways.
maleylacetoacetate isomerase deficiency
Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate-cysteine ligase.
maleylacetoacetate isomerase deficiency
Hypersuccinylacetonaemia and normal liver function in maleylacetoacetate isomerase deficiency.
maleylacetoacetate isomerase deficiency
Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency.
maleylacetoacetate isomerase deficiency
Phenylalanine-induced leucopenia in genetic and dichloroacetic acid generated deficiency of glutathione transferase Zeta.
Metabolic Diseases
Chloride concentrations in human hepatic cytosol and mitochondria are a function of age.
Neoplasms
GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate.
Neoplasms
Prenatal and postnatal expression of glutathione transferase ? 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.
Tyrosinemias
Gene structure, chromosomal location, and expression pattern of maleylacetoacetate isomerase.
Tyrosinemias
Tyrosinemia type I: a clinico-laboratory case report.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Seltzer, S.
cis-trans Isomerization
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
6
381-406
1972
Vibrio sp.
-
brenda
Hagedorn, S.R.; Chapman, P.J.
Glutathione-independent maleylacetoacetate isomerase in gram-positive bacteria
J. Bacteriol.
163
803-805
1985
Corynebacterium sp., Moraxella sp., Nocardia globerula, Nocardia globerula CL1, Pseudomonas alcaligenes, Rhodococcus rhodnii
brenda
Feliu, A.L.; Smith, K.J.; Seltzer, S.
Unique, one-step, double isomerization (2E,4Z<-->2Z,4E) of 6-oxo-2,4-heptadienoic acid catalyzed by maleylacetone cis-trans isomerase
J. Am. Chem. Soc.
106
3046-3047
1984
Vibrio sp., Vibrio sp. 1
-
brenda
Lin, M.; Seltzer, S.
Maleylacetone cis-trans isomerase: formation of an N-ethylmaleimide-labeled enzyme only during the slow phase of the biphasic inhibition reaction
FEBS Lett.
124
169-172
1981
Vibrio sp.
-
brenda
Seltzer, S.; Lin, M.
Maleylacetone cis-trans-Isomerase. Mechanism of the interaction of coenzyme glutathione and substrate maleylacetone in the presence and absence of enzyme
J. Am. Chem. Soc.
101
3091-3097
1979
Vibrio sp.
-
brenda
Morrison, W.S.; Wong, G.; Seltzer, S.
Maleylacetone cis-trans-isomerase: affinity chromatography on glutathione-bound Sepharose. Two-substrate-binding sequence from inhibition patterns
Biochemistry
15
4228-4233
1976
Vibrio sp.
brenda
Seltzer, S.
Purification and properties of maleylacetone cis-trans isomerase from Vibrio 01
J. Biol. Chem.
248
215-222
1973
Vibrio sp.
brenda
Whitlow, K.J.; D'Iorio, A.; Mavrides, C.
Regulation of the enzymes of tyrosine catabolism in Tetrahymena pyriformis
Biochim. Biophys. Acta
264
440-449
1972
Tetrahymena pyriformis, Tetrahymena pyriformis W
brenda
Lack, L.
Enzymic cis-trans isomerization of maleylpyruvic acid
J. Biol. Chem.
236
2835-2840
1961
Pseudomonas sp.
brenda
Fernandez-Canon, J.M.; Penalva, M.A.
Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue
J. Biol. Chem.
273
329-337
1998
Aspergillus nidulans, Aspergillus nidulans (O43123), Homo sapiens, Homo sapiens (O43708)
brenda
Seltzer, S.; Hane, J.
Maleylacetate cis-trans isomerase: one-step double cis-trans isomerization of monomethyl muconate and the enzyme's probable role in benzene metabolism
Bioorg. Chem.
16
394-407
1988
Vibrio sp.
-
brenda
Angaw-Duguma, L.; Marecek, J.; Seltzer, S.
The synthesis and enzyme-catalyzed one-step cis-trans double isomerization of monomethyl 5-oxo-1,3-hexadien-1-ylphosphonate, an analogue of maleylacetone
Bioorg. Chem.
20
213-222
1992
Vibrio sp.
-
brenda
Seltzer, S.
Maleylacetoacetate cis-trans isomerase
Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York
3
733-751
1989
Mammalia, Vibrio sp.
-
brenda
Lee, H.E.; Seltzer, S.
cis-beta-Acetylacrylate is a substrate for maleylacetoacetate cis-trans isomerase. Mechanistic implications
Biochem. Int.
18
91-97
1989
Vibrio sp.
brenda
Board, P.G.; Taylor, M.C.; Coggan, M.; Parker, M.W.; Lantum, H.B.; Anders, M.W.
Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique
Biochem. J.
374
731-737
2003
Homo sapiens
brenda
Polekhina, G.; Board, P.G.; Blackburn, A.C.; Parker, M.W.
Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity
Biochemistry
40
1567-1576
2001
Homo sapiens, Homo sapiens (O43708)
brenda
Lim, C.E.; Matthaei, K.I.; Blackburn, A.C.; Davis, R.P.; Dahlstrom, J.E.; Koina, M.E.; Anders, M.W.; Board, P.G.
Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases
Am. J. Pathol.
165
679-693
2004
Mus musculus
brenda
Qiang, L.; Farmer, S.R.
C/EBPalpha-dependent induction of glutathione S-transferase zeta/maleylacetoacetate isomerase (GSTzeta/MAAI) expression during the differentiation of mouse fibroblasts into adipocytes
Biochem. Biophys. Res. Commun.
340
845-851
2006
Mus musculus
brenda
Dixon, D.P.; Edwards, R.
Enzymes of tyrosine catabolism in Arabidopsis thaliana
Plant Sci.
171
360-366
2006
Arabidopsis thaliana, Arabidopsis thaliana (Q9ZVQ3)
brenda
Theodoratos, A.; Tu, W.J.; Cappello, J.; Blackburn, A.C.; Matthaei, K.; Board, P.G.
Phenylalanine-induced leucopenia in genetic and dichloroacetic acid generated deficiency of glutathione transferase Zeta
Biochem. Pharmacol.
77
1358-1363
2009
Mus musculus
brenda
Shroads, A.L.; Langaee, T.; Coats, B.S.; Kurtz, T.L.; Bullock, J.R.; Weithorn, D.; Gong, Y.; Wagner, D.A.; Ostrov, D.A.; Johnson, J.A.; Stacpoole, P.W.
Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate
J. Clin. Pharmacol.
52
837-849
2012
Homo sapiens
brenda
html completed