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EC Number Application Commentary Reference
Show all pathways known for 5.2.1.2Display the word mapDisplay the reaction diagram Show all sequences 5.2.1.2medicine cis and/or trans isomers of 2,4-dioxohept-2-enoic acid might be diagnostic for human deficiency of maleylacetoacetate isomerase 2468
Show all pathways known for 5.2.1.2Display the word mapDisplay the reaction diagram Show all sequences 5.2.1.2medicine dichloroacetate, a degradation product of chloral hydrate, is further metabolized by glutathione transferase zeta 1, and inhibits its own metabolism through depletion/inactivation of GSTZ1/MAAI with repeated exposure, resulting in lower plasma clearance of the drug and the accumulation of the urinary biomarker maleylacetone. The amount of dichloroacetate produced from clinically relevant doses of chloral hydrate, although insufficient to alter dichloroacetate kinetics, is sufficient to inhibit MAAI and tyrosine catabolism 747644
Show all pathways known for 5.2.1.2Display the word mapDisplay the reaction diagram Show all sequences 5.2.1.2more knowledge of the GSTz1/MAAI haplotype can be used prospectively to identify individuals at potential risk of dichloroacetate’s adverse side effects from environmental or clinical exposure or who may exhibit aberrant amino acid metabolism in response to dietary protein 728222
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