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Literature summary for 5.2.1.2 extracted from

  • Fernandez-Canon, J.M.; Penalva, M.A.
    Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue (1998), J. Biol. Chem., 273, 329-337.
    View publication on PubMed
Search for more literature for 5.2.1.2

Application

Application Comment Organism
medicine cis and/or trans isomers of 2,4-dioxohept-2-enoic acid might be diagnostic for human deficiency of maleylacetoacetate isomerase Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens
expression in Escherichia coli Aspergillus nidulans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Maleylacetoacetate Homo sapiens human maleylacetoacetate isomerase deficiency presumably causes tyrosinemia that can be characterized by the absence of succinylacetone ?
-
 ?
Maleylacetoacetate Aspergillus nidulans enzyme of the phenylacetate pathway ?
-
 ?
additional information Homo sapiens enzyme deficiency would presumably cause tyrosinemia that would be characterized by the absence of succinylacetone ?
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
-
-
Aspergillus nidulans O43123
-
-
Homo sapiens
-
-
-
Homo sapiens O43708
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Maleylacetoacetate human maleylacetoacetate isomerase deficiency presumably causes tyrosinemia that can be characterized by the absence of succinylacetone Homo sapiens ?
-
 ?
Maleylacetoacetate enzyme of the phenylacetate pathway Aspergillus nidulans ?
-
 ?
additional information enzyme deficiency would presumably cause tyrosinemia that would be characterized by the absence of succinylacetone Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MAAI
-
 Aspergillus nidulans
MAAI
-
 Homo sapiens