EC Number |
Inhibitors |
Structure |
---|
5.2.1.2 | (3Z)-1,3-butadiene-1,1,2,4-tetrol |
competitive inhibitor identified by rational design, calculated to be no substrate and not inhibitory to CYP450 and nontoxic in AMES test |
|
5.2.1.2 | (Z)-3-[4-hydroxy-1-(hydroxymethyl)cyclohexyl]-2-propene-1,2-diol |
competitive inhibitor identified by rational design, calculated to be no substrate and not inhibitory to CYP450 and nontoxic in AMES test |
|
5.2.1.2 | Dichloroacetate |
the sensitivity to the inhibitor varies between enzyme haplotypes. Three nonsynonymous single-nucleotide polymorphisms of GSTz1/MAAI show different activity toward dichloroacetate and certain other xenobiotic haloacids |
|
5.2.1.2 | Dichloroacetic acid |
DCA |
|
5.2.1.2 | GSSG |
- |
|
5.2.1.2 | iodoacetate |
- |
|
5.2.1.2 | maleylacetone |
inhibits isomerization of 6-oxo-2(E),4(Z)-heptanedienoic acid into 6-oxo-2(Z),4(E)-heptanedienoic acid, and the reverse reaction |
|
5.2.1.2 | N-Hexylmaleamic acid |
noncompetitive towards GSH and maleylacetone |
|
5.2.1.2 | NaBH4 |
inhibition in absence of substrate, increases activity in presence of substrate and GSH |
|
5.2.1.2 | NEM |
biphasic kinetics |
|