Reference on EC 4.6.1.12 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Takagi, M.; Kuzuyama, T.; Kaneda, K.; Watanabe, H.; Dairi, T.; Seto, H.
Studies on the nonmevalonate pathway: Formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate from 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
Tetrahedron Lett.
41
3395-3398
2000
Escherichia coli, Escherichia coli (P62617)
-
Manually annotated by BRENDA team
Kishida, H.; Wada, T.; Unzai, S.; Kuzuyama, T.; Takagi, M.; Terada, T.; Shirouzu, M.; Yokoyama, S.; Tame, J.R.; Park, S.Y.
Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis
Acta Crystallogr. Sect. D
59
23-31
2003
Thermus thermophilus (Q8RQP5)
Manually annotated by BRENDA team
Ni, S.; Robinson, H.; Marsing, G.C.; Bussiere, D.E.; Kennedy, M.A.
Structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase from Shewanella oneidensis at 1.6 ANG: identification of farnesyl pyrophosphate trapped in a hydrophobic cavity
Acta Crystallogr. Sect. D
D60
1949-1957
2004
Shewanella oneidensis, Shewanella oneidensis MR1
Manually annotated by BRENDA team
Rohdich, F.; Eisenreich, W.; Wungsintaweekul, J.; Hecht, S.; Schuhr, C.A.; Bacher, A.
Biosynthesis of terpenoids. 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF) from Plasmodium falciparum
Eur. J. Biochem.
268
3190-3197
2001
Plasmodium falciparum (P62368), Plasmodium falciparum
Manually annotated by BRENDA team
Campbell, T.L.; Brown, E.D.
Characterization of the depletion of 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase in Escherichia coli and Bacillus subtilis
J. Bacteriol.
184
5609-5618
2002
Escherichia coli
Manually annotated by BRENDA team
Richard, S.B.; Ferrer, J.L.; Bowman, M.E.; Lillo, A.M.; Tetzlaff, C.N.; Cane, D.E.; Noel, J.P.
Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway
J. Biol. Chem.
277
8667-8672
2002
Escherichia coli (P62617)
Manually annotated by BRENDA team
Gabrielsen, M.; Bond, C.S.; Hallyburton, I.; Hecht, S.; Bacher, A.; Eisenreich, W.; Rohdich, F.; Hunter, W.N.
Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis
J. Biol. Chem.
279
52753-52761
2004
Agrobacterium tumefaciens, Campylobacter jejuni, Escherichia coli, Escherichia coli (P62617)
Manually annotated by BRENDA team
Steinbacher, S.; Kaiser, J.; Wungsintaweekul, J.; Hecht, S.; Eisenreich, W.; Gerhardt, S.; Bacher, A.; Rohdich, F.
Structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids
J. Mol. Biol.
316
79-88
2002
Escherichia coli
Manually annotated by BRENDA team
Herz, S.; Wungsintaweekul, J.; Schuhr, C.A.; Hecht, S.; Lüttgen, H.; Sagner, S.; Fellermeier, M.; Eisenreich, W.; Zenk, M.H.; Bacher, A.; Rohdich, F.
Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate
Proc. Natl. Acad. Sci. USA
97
2486-2490
2000
Escherichia coli, Escherichia coli (P62617)
Manually annotated by BRENDA team
Kemp, L.E.; Bond, C.S.; Hunter, W.N.
Structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development
Proc. Natl. Acad. Sci. USA
99
6591-6596
2002
Escherichia coli, Escherichia coli (P62617)
Manually annotated by BRENDA team
Lehmann, C.; Lim, K.; Toedt, J.; Krajewski, W.; Howard, A.; Eisenstein, E.; Herzberg, O.
Structure of 2C-methyl-D-erythrol-2,4-cyclodiphosphate synthase from Haemophilus influenzae: Activation by conformational transition
Proteins
49
135-138
2002
Haemophilus influenzae, Haemophilus influenzae (P44815)
Manually annotated by BRENDA team
Sgraja, T.; Kemp, L.E.; Ramsden, N.; Hunter, W.N.
A double mutation of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate
Acta Crystallogr. Sect. F
F61
625-629
2005
Escherichia coli
Manually annotated by BRENDA team
Kim, S.M.; Kuzuyama, T.
Cloning and characterization of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECS) gene from Ginkgo biloba
Plant Cell Rep.
8
829-835
2006
Ginkgo biloba (Q1EDG4)
-
Manually annotated by BRENDA team
Lherbet, C.; Pojer, F.; Richard, S.B.; Noel, J.P.; Poulter, C.D.
Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway
Biochemistry
45
3548-3553
2006
Agrobacterium tumefaciens
Manually annotated by BRENDA team
Illarionova, V.; Kaiser, J.; Ostrozhenkova, E.; Bacher, A.; Fischer, M.; Eisenreich, W.; Rohdich, F.
Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods
J. Org. Chem.
71
8824-8834
2006
Plasmodium sp.
Manually annotated by BRENDA team
Baumgartner, C.; Eberle, C.; Diederich, F.; Lauw, S.; Rohdich, F.; Eisenreich, W.; Bacher, A.
Structure-based design and synthesis of the first weak non-phosphate inhibitors for IspF, an enzyme in the non-mevalonate pathway of isoprenoid biosynthesis
Helv. Chim. Acta
90
1043-1068
2007
Escherichia coli (P62617)
-
Manually annotated by BRENDA team
Jin, H.; Gong, Y.; Guo, B.; Qiu, C.; Liu, D.; Miao, Z.; Sun, X.; Tang, K.
Isolation and characterization of a 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase gene from Taxus media
Mol. Biol.
40
914-921
2006
Taxus x media (A1X5Y0)
-
Manually annotated by BRENDA team
Hsieh, M.; Goodman, H.M.
Functional evidence for the involvement of Arabidopsis IspF homolog in the nonmevalonate pathway of plastid isoprenoid biosynthesis
Planta
223
779-784
2006
Arabidopsis thaliana
Manually annotated by BRENDA team
Calisto, B.M.; Perez-Gil, J.; Bergua, M.; Querol-Audi, J.; Fita, I.; Imperial, S.
Biosynthesis of isoprenoids in plants: Structure of the 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Arabidopsis thaliana. Comparison with the bacterial enzymes
Protein Sci.
16
2082-2088
2007
Arabidopsis thaliana, Arabidopsis thaliana (Q9CAK8)
Manually annotated by BRENDA team
Sando, T.; Takeno, S.; Watanabe, N.; Okumoto, H.; Kuzuyama, T.; Yamashita, A.; Hattori, M.; Ogasawara, N.; Fukusaki, E.; Kobayashi, A.
Cloning and characterization of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway genes of a natural-rubber producing plant, Hevea brasiliensis
Biosci. Biotechnol. Biochem.
72
2903-2917
2008
Hevea brasiliensis (A9ZN12), Hevea brasiliensis
Manually annotated by BRENDA team
Chen, J.; Xiao, Y.; Di, P.; Yu, X.; Chen, W.; Zhang, L.
Molecular cloning and characterization of a 2C-methyl-D: -erythritol 2,4-cyclodiphosphate synthase gene from Cephalotaxus harringtonia
Mol. Biol. Rep.
36
1749-1756
2008
Cephalotaxus harringtonia
Manually annotated by BRENDA team
Narayanasamy, P.; Eoh, H.; Crick, D.C.
Chemoenzymatic synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol: a substrate for IspE
Tetrahedron Lett.
49
4461-4463
2008
Mycobacterium tuberculosis, Mycobacterium tuberculosis Rv3582c
Manually annotated by BRENDA team
Battilana, J.; Costantini, L.; Emanuelli, F.; Sevini, F.; Segala, C.; Moser, S.; Velasco, R.; Versini, G.; Stella Grando, M.
The 1-deoxy-D: -xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevine
Theor. Appl. Genet.
118
653-669
2009
Vitis vinifera x Vitis riparia, Vitis vinifera x Vitis vinifera
Manually annotated by BRENDA team
Geist, J.G.; Lauw, S.; Illarionova, V.; Illarionov, B.; Fischer, M.; Graewert, T.; Rohdich, F.; Eisenreich, W.; Kaiser, J.; Groll, M.; Scheurer, C.; Wittlin, S.; Alonso-Gomez, J.L.; Schweizer, W.B.; Bacher, A.; Diederich, F.
Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum
ChemMedChem
5
1092-1101
2010
Arabidopsis thaliana, Arabidopsis thaliana (Q9CAK8), Escherichia coli, Mycobacterium tuberculosis, Mycobacterium tuberculosis (P9WKG5), Mycobacterium tuberculosis H37Rv (P9WKG5), Plasmodium falciparum (P62369), Plasmodium falciparum, Plasmodium falciparum NF54 (P62369)
Manually annotated by BRENDA team
Ramsden, N.L.; Buetow, L.; Dawson, A.; Kemp, L.A.; Ulaganathan, V.; Brenk, R.; Klebe, G.; Hunter, W.N.
A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy
J. Med. Chem.
52
2531-2542
2009
Escherichia coli, Escherichia coli (P62617)
Manually annotated by BRENDA team
Liu, W.; Chen, M.; Yang, C.; Yang, Y.; Lan, X.; Liao, Z.
A new 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase gene from Taxus media: Cloning, characterization and functional complementation
J. Med. Plant Res.
3
395-402
2009
Taxus x media (D3G6G3)
-
Manually annotated by BRENDA team
Narayanasamy, P.; Eoh, H.; Brennan, P.J.; Crick, D.C.
Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF, a potential drug target
Chem. Biol.
17
117-122
2010
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Jung, Y.; Choi, J.; Sun, J.; Nou, I.; Cho, Y.; Kang, K.
Molecular and functional characterization of a Brmecp gene encoding 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Brassica rapa
J. Plant Biotechnol.
39
189-195
2012
Brassica rapa
-
Manually annotated by BRENDA team
Kumar, H.; Singh, K.; Kumar, S.
2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase from Stevia rebaudiana Bertoni is a functional gene
Mol. Biol. Rep.
39
10971-10978
2012
Stevia rebaudiana (Q0Q5B3), Stevia rebaudiana
Manually annotated by BRENDA team
Zheng, Y.; Chen, M.; Yang, C.; Ming, X.; Liu, X.; Lan, X.; Liao, Z.
Cloning and characterization of MECS and HDS genes from Rauvolfia verticillata
Plant OMICS
4
82-90
2011
Rauvolfia verticillata
-
Manually annotated by BRENDA team
Liu, Z.; Jin, Y.; Tao, Y.; Wang, G.
Crystal structure of IspF from Bacillus subtilis and absence of protein complex assembly amongst IspD/IspE/IspF enzymes in the MEP pathway
Biosci. Rep.
38
BSR20171370
2018
Bacillus subtilis 168 (Q06756), Bacillus subtilis (Q06756)
Manually annotated by BRENDA team
Mandal, S.; Upadhyay, S.; Singh, V.P.; Kapoor, R.
Enhanced production of steviol glycosides in mycorrhizal plants a concerted effect of arbuscular mycorrhizal symbiosis on transcription of biosynthetic genes
Plant Physiol. Biochem.
89
100-106
2015
Stevia rebaudiana
Manually annotated by BRENDA team