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Information on EC 4.4.1.14 - 1-aminocyclopropane-1-carboxylate synthase
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4.4.1.14 1-aminocyclopropane-1-carboxylate synthaseIUBMB Comments
A pyridoxal 5'-phosphate protein. The enzyme catalyses an alpha,gamma-elimination.
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Word Map
- 4.4.1.14
- ethylene
- tomato
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ripening
- seedlings
- flower
- auxin
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etiolated
-
phytohormone
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climacteric
- hypocotyls
- agriculture
- malus
- lycopersicon
- aminoethoxyvinylglycine
- esculentum
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ripening-related
- 1-methylcyclopropene
- cucumis
-
auxin-induced
- dianthus
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aerenchyma
- carnation
-
ethephon
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ethylene-forming
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ethylene-induced
- caryophyllus
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ethylene-mediated
- 1-amino-cyclopropane-1-carboxylate
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preclimacteric
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iaa-induced
- food industry
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monoecious
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wound-induced
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
acc synthase, 1-aminocyclopropane-1-carboxylate synthase, 1-aminocyclopropane-1-carboxylic acid synthase, mdacs1, le-acs2, acs-1, leacs2, le-acs4, le-acs3, ghacs1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1-aminocyclopropane carboxylic acid synthase
1-aminocyclopropane-1-carboxylate synthase
1-aminocyclopropane-1-carboxylate synthase 4
1-aminocyclopropane-1-carboxylate synthetase
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1-aminocyclopropane-1-carboxylic acid synthase
1-aminocyclopropanecarboxylate synthase
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ACC synthase
ACS
ACS1
ACS2
ACS3
ACS4
ACS5
ACS6
aminocyclopropane-1-carboxylate synthase
aminocyclopropanecarboxylate synthase
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aminocyclopropanecarboxylic acid synthase
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PgACS4
S-adenosyl-L-methionine methylthioadenosine-lyase
S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming)
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synthase, 1-aminocyclopropanecarboxylate
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type 2 1-aminocyclopropane-1-carboxylate synthase
1-aminocyclopropane carboxylic acid synthase
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1-aminocyclopropane-1-carboxylate synthase
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1-aminocyclopropane-1-carboxylic acid synthase
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ACC synthase
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ACC synthase
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aminocyclopropane-1-carboxylate synthase
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S-adenosyl-L-methionine methylthioadenosine-lyase
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S-adenosyl-L-methionine methylthioadenosine-lyase
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S-adenosyl-L-methionine methylthioadenosine-lyase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine
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S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine
stereochemistry
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S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
elimination
additional information
elimination
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of H2S or RSH, C-S bond cleavage
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elimination
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alpha, gamma-elimination
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additional information
14-3-3 protein may inhibit binding to ethylene overproducer 1 proteins, resulting in 1-aminocyclopropane-1-carboxylate and ethylene synthesis
additional information
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14-3-3 protein may inhibit binding to ethylene overproducer 1 proteins, resulting in 1-aminocyclopropane-1-carboxylate and ethylene synthesis
additional information
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by Agrobacterium mediated transformation, two transgenic pineapple lines have been produced containing co-suppression constructs designed to down-regulate the expression of the ACACS2 gene
additional information
high levels of expression of CyACS1 in the necrotic inflorescences of wild-type Cymbidium at high temperatures, no bud necrosis in the mericlone mutant, but application of exogenous ACC or ethephon to the young inflorescences of nhn restored the high-temperature necrosis response
additional information
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LE-ACS3 shows a strong interaction with the protein ethylene overproducer 1, the C-terminal tail of ACS is essential for the interaction with ethylene overproducer 1 and signals the proteasome-dependent protein destabilization
additional information
LE-ACS3 shows a strong interaction with the protein ethylene overproducer 1, the C-terminal tail of ACS is essential for the interaction with ethylene overproducer 1 and signals the proteasome-dependent protein destabilization
additional information
two introns are in the genomic DNA sequence, Southern blot analysis suggests that there might be a multi-gene family encoding for ACC synthase, alignment analysis shows a close association with the wound-inducible ACS of citrus
additional information
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two introns are in the genomic DNA sequence, Southern blot analysis suggests that there might be a multi-gene family encoding for ACC synthase, alignment analysis shows a close association with the wound-inducible ACS of citrus
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine S-methyl-5'-thioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming)
A pyridoxal 5'-phosphate protein. The enzyme catalyses an alpha,gamma-elimination.
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CAS REGISTRY NUMBER
COMMENTARY
72506-68-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-arginine + pyridoxal 5'-phosphate
2-oxo-5-guanidinopentanoate + pyridoxamine 5'-phosphate
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?
L-aspartate + pyridoxal 5'-phosphate
2-oxo-succinate + pyridoxamine 5'-phosphate
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very slow transamination activity
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?
L-phenylalanine + pyridoxal 5'-phosphate
2-oxo-3-phenylpropanoate + pyridoxamine 5'-phosphate
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slow transamination activity
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?
pyridoxal 5'-phosphate + alanine
pyridoxamine 5'-phosphate + pyruvate
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?
S-methyl-L-methionine + pyridoxal 5'-phosphate
4-dimethylsulfonium-2-oxobutyrate + pyridoxamine 5'-phosphate
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transamination reaction
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?
(R,S)-S-adenosyl-L-methionine
vinylglycine + methylthioadenosine
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-
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?
(R,S)-S-adenosyl-L-methionine
vinylglycine + methylthioadenosine
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?
(S,S)-S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
(S,S)-S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
L-alanine + pyridoxal 5'-phosphate
pyruvate + pyridoxamine 5'-phosphate
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?
L-alanine + pyridoxal 5'-phosphate
pyruvate + pyridoxamine 5'-phosphate
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
-
-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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biosynthesis of ethylene: plant hormone
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
-
biosynthesis of ethylene: plant hormone
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
biosynthesis of ethylene: plant hormone
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
Diospyros sp.
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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rate-determining step in the biosynthesis of ethylene
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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biosynthesis of ethylene: plant hormone
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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ir
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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ir
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
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-
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?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
-
-
-
?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
-
biosynthesis of ethylene: plant hormone
-
-
?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
-
-
-
?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
-
-
-
?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
-
biosynthesis of ethylene: plant hormone
-
-
?
S-adenosyl-L-methionine
1-aminocyclopropane-1-carboxylate + methylthioadenosine
-
-
-
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?
S-methyl-L-methionine
alpha-ketobutyrate + ammonia + dimethylsulfide
-
-
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?
S-methyl-L-methionine
alpha-ketobutyrate + ammonia + dimethylsulfide
-
beta,gamma elimination of dimethylsulfide to yield enzyme bound L-vinylglycine, which is subsequently converted to alpha-ketobutyrate and ammonia
-
?
additional information
?