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Literature summary for 4.4.1.14 extracted from

  • Yoon, G.M.; Kieber, J.J.
    14-3-3 regulates 1-aminocyclopropane-1-carboxylate synthase protein turnover in Arabidopsis (2013), Plant Cell, 25, 1016-1028.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.4.1.14

Cloned(Commentary)

Cloned (Comment) Organism
coexpression of HA-tagged EOL2, HA-tagged isozyme ACS5, and increasing levels of HA-tagged 14-3-3omega protein in Arabidospis thaliana protoplasts, seedling phenotypes, overview Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information a transient expression system in Arabidopsis protoplasts is used to determine if the interaction with 14-3-3 protein increases the half-life of ACS5. Coexpression of HA-14-3-3v increases the half-life of myc-tagged ACS5 protein in this system Arabidopsis thaliana

General Stability

General Stability Organism
14-3-3 proteins interact with multiple 1-aminocyclopropane-1-carboxylate synthase isoforms in Arabidopsis thaliana leading to stabilization of the isozymes Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Arabidopsis thaliana 5737
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Synonyms

Synonyms Comment Organism
ACS
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the generally rate-limiting step in the biosynthesis of the phytohormone ethylene. 14-3-3 proteins exhibit a regulatory function in the pathway by reducing the degradation of 1-aminocyclopropane-1-carboxylate synthase through components of a CULLIN-3 E3 ubiquitin ligase, i.e. ethylene-overproducer 1-like proteins or ETO1/EOLs, that target a subset of the 1-aminocyclopropane-1-carboxylate synthase proteins for rapid degradation by the 26S proteasome. 14-3-3 protein positively regulates type-2 ACS protein stability by both increasing the turnover of the ETO1/EOL BTB E3 ligases that target type-2 ACS proteins and by an ETO1/EOL-independent mechanism. 14-3-3 protein promotes the degradation of ETO1/EOLs, likely via the 26S proteasome pathway Arabidopsis thaliana
additional information 14-3-3 proteins interact with multiple 1-aminocyclopropane-1-carboxylate synthase isoforms in Arabidopsis thaliana, 14-3-3 likely acts on all three classes of enzyme proteins Arabidopsis thaliana