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Information on EC 4.2.3.57 - (-)-beta-caryophyllene synthase for references in articles please use BRENDA:EC4.2.3.57Word Map on EC 4.2.3.57
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The enzyme appears in viruses and cellular organisms
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(-)-beta-caryophyllene synthase
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(2E,6E)-farnesyl diphosphate = (-)-beta-caryophyllene + diphosphate
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beta-caryophyllene biosynthesis
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oleoresin sesquiterpene volatiles biosynthesis
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Sesquiterpenoid and triterpenoid biosynthesis
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Biosynthesis of secondary metabolites
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(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(-)-beta-caryophyllene-forming]
Widely distributed in higher plants, cf. EC 4.2.3.89 (+)-beta-caryophyllene synthase.
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(E)-beta-caryophyllene synthase
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CarS
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TPS1
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brenda
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UniProt
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UniProt
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Scots pine
UniProt
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-
UniProt
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isoform TPS1
UniProt
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physiological function
flowers of plant lines lacking (E)-beta-caryophyllene emission show greater bacterial growth on their stigmas than wild-type flowers, and their seeds are lighter and misshapen. Plant lines with ectopic (E)-beta-caryophyllene emission from vegetative parts are more resistant than wild-type plants to pathogen infection of leaves, and show reduced cell damage and higher seed production. (E)-beta-caryophyllene seems to act by direct inhibition of bacterial growth
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(2E,6E)-farnesyl diphosphate
(E)-beta-caryophyllene + alpha-humulene + alpha-copaene + diphosphate
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alpha-humulene and alpha-copaene are minor products besides the main product (E)-beta-caryophyllene
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(2E,6E)-farnesyl diphosphate
(E)-beta-caryophyllene + alpha-humulene + diphosphate
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TPS 1 forms two main products: (E)-beta-caryophyllene and alpha-humulene with 76.3 and 23.7%, respectively
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(2E,6E)-farnesyl diphosphate
(E)-beta-caryophyllene + diphosphate
(2E,6E)-farnesyl diphosphate
beta-caryophyllene + diphosphate
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enzyme produces beta-caryophyllene and alpha-humulene in a ratio of 71:29
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Geranyl diphosphate
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production of several monoterpenes among which myrcene, limonene and camphene can be clearly identified
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additional information
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no substrate: geranyl diphosphate
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(2E,6E)-farnesyl diphosphate
(E)-beta-caryophyllene + diphosphate
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79% (E)-beta-caryophyllene plus 21% alpha-humulene
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(2E,6E)-farnesyl diphosphate
(E)-beta-caryophyllene + diphosphate
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0.0289
(2E,6E)-farnesyl diphosphate
30°C, pH not specified in the publication
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lowest expression level
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highest expression in stage 2 inflorescences, transcript levels are over 30fold higher than those of leaves
brenda
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highest expression level
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slight expression
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brenda
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slight expression in young leaf, medium leaf and old leaf
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63600
x * 63600, calculated
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expressed in Escherichia coli BL21 (DH3) pLysS cells
expressed in Escherichia coli BL21 cells
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expression is induced upon wounding or methyljasmonate treatment
Methyl jasmonate treatment results in a significant increase of TPS1 transcript accumulation in all developmental stages of the leaves
transcript level of TPS 1 is significantly higher in oviposition-induced twigs that are attractive to the parasitoid Diprion pini than in non-attractive, artificially damaged twigs. Transcript levels of PsTPS 1 also changes significantly over time with a striking increase 72 h after oviposition
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agriculture
flowers of plant lines lacking (E)-beta-caryophyllene emission show greater bacterial growth on their stigmas than wild-type flowers, and their seeds are lighter and misshapen. Plant lines with ectopic (E)-beta-caryophyllene emission from vegetative parts are more resistant than wild-type plants to pathogen infection of leaves, and show reduced cell damage and higher seed production. (E)-beta-caryophyllene seems to act by direct inhibition of bacterial growth
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CARS_ARTAN
548
63737
Swiss-Prot
BCAS_SACES
Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 / NBRC 15066 / NRRL 15764)
353
39205
Swiss-Prot
TPS1_MATCR
547
63465
Swiss-Prot
A0A2D1CN32_MENAQ
85
10084
TrEMBL
HUMS_ARATH
547
63619
Swiss-Prot
U3LVZ7_LAVAN
548
63644
TrEMBL
K7PRF2_GOSHI
545
63283
TrEMBL
B4XAK4_PINSY
575
66729
TrEMBL
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Köpke, D.; Schröder, R.; Fischer, H.M.; Gershenzon, J.; Hilker, M.; Schmidt, A.
Does egg deposition by herbivorous pine sawflies affect transcription of sesquiterpene synthases in pine?
Planta
228
427-438
2008
Pinus sylvestris (B4XAK4)
brenda
Abel, C.; Clauss, M.; Schaub, A.; Gershenzon, J.; Tholl, D.
Floral and insect-induced volatile formation in Arabidopsis lyrata ssp. petraea, a perennial, outcrossing relative of A. thaliana
Planta
230
1-11
2009
Arabidopsis lyrata subsp. petraea
brenda
Huang, M.; Sanchez-Moreiras, A.M.; Abel, C.; Sohrabi, R.; Lee, S.; Gershenzon, J.; Tholl, D.
The major volatile organic compound emitted from Arabidopsis thaliana flowers, the sesquiterpene (E)-beta-caryophyllene, is a defense against a bacterial pathogen
New Phytol.
193
997-1008
2012
Arabidopsis thaliana (Q84UU4)
brenda
Yang, C.Q.; Wu, X.M.; Ruan, J.X.; Hu, W.L.; Mao, Y.B.; Chen, X.Y.; Wang, L.J.
Isolation and characterization of terpene synthases in cotton (Gossypium hirsutum)
Phytochemistry
96
46-56
2013
Gossypium hirsutum (K7PRF2)
brenda
Jullien, F.; Moja, S.; Bony, A.; Legrand, S.; Petit, C.; Benabdelkader, T.; Poirot, K.; Fiorucci, S.; Guitton, Y.; Nicole, F.; Baudino, S.; Magnard, J.L.
Isolation and functional characterization of a tau-cadinol synthase, a new sesquiterpene synthase from Lavandula angustifolia
Plant Mol. Biol.
84
227-241
2014
Lavandula angustifolia (U3LVZ7)
brenda
Huang, X.; Xiao, Y.; Koellner, T.G.; Zhang, W.; Wu, J.; Wu, J.; Guo, Y.; Zhang, Y.
Identification and characterization of (E)-beta-caryophyllene synthase and alpha/alpha-pinene synthase potentially involved in constitutive and herbivore-induced terpene formation in cotton
Plant Physiol. Biochem.
73
302-308
2013
Gossypium hirsutum (K7PRF2)
brenda
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