Reference on EC 4.2.3.4 - 3-dehydroquinate synthase
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Saijo, R.; Takeo, T.
Some properties of the initial four enzymes involved in shikimic acid biosynthesis in tea plant
Agric. Biol. Chem.
43
1427-1432
1979
Camellia sinensis
-
Bode, R.; Birnbaum, D.
Aggregation und Trennbarkeit der Enzyme des Shikimat-Pathway bei Hefen
Z. Allg. Mikrobiol.
21
417-422
1981
Saccharomyces cerevisiae, Meyerozyma guilliermondii, Wickerhamomyces anomalus, Cyberlindnera jadinii, Cyberlindnera fabianii, Ogataea henricii, Lodderomyces elongisporus, Neurospora crassa, Rhodotorula sphaerocarpa, Rhodotorula toruloides, Rhodotorula mucilaginosa, Saccharomycopsis lipolytica
Mousdale, D.M.; Coggins, J.R.
Subcellular localization of the common shikimate-pathway enzymes in Pisum sativum L.
Planta
163
241-249
1985
Pisum sativum
Euverink, G.J.W.; Hessels, G.I.; Vrijbloed, J.W.; Coggins, J.R.; Dijkhuizen, L.
Purification and characterization of a dual function 3-dehydroquinate dehydratase from Amycolatopsis methanolica
J. Gen. Microbiol.
138
2449-2457
1992
Amycolatopsis methanolica
Myrvold, S.; Reimer, L.M.; Pompliano,D.L.; Frost, J.W.
Chemical inhibition of dehydroquinate synthase
J. Am. Chem. Soc.
111
1861-1866
1989
Escherichia coli
-
Pompliano, D.L.; Reimer, L.M.; Myrvold, S.; Frost, J.W.
Probing lethal metabolic perturbations in plants with chemical inhibition of dehydroquinate synthase
J. Am. Chem. Soc.
111
1866-1871
1989
Pisum sativum
-
Matsui, K.; Miwa, K.; Sano, K.
Cloning of a gene cluster of aroB, aroE and aroL for aromatic amino acid biosynthesis in Brevibacterium lactofermentum, a glutamic acid-producing bacterium
Agric. Biol. Chem.
52
525-531
1988
Corynebacterium glutamicum
-
Bereswill, S; Fassbinder, F.; Voelzing, C.; Haas, R.; Reuter, K.; Ficner, R.; Kist, M.
Cloning and functional characterization of the genes encoding 3-dehydroquinate synthase (aroB) and tRNA-guanine transglycosylase (tgt) from Helicobacter pylori
Med. Microbiol. Immunol.
186
125-134
1997
Helicobacter pylori
Mehdi, S.; Frost, J.W.; Knowles, J.R.
Dehydroquinate synthase from Escherichia coli, and its substrate 3-deoxy-D-arabino-heptulosonic acid 7-phosphate
Methods Enzymol.
142
306-314
1987
Escherichia coli
Coggins, J.R.; Duncan, K.; Anton, I.A.; Boocock, M.R.; Chaudhuri, S.; Lambert, J.M.; Lewendon, A.; Millar, G.; Mousdale, D.M.; Smith, D.D.S.
The anatomy of a multifunctional enzyme
Biochem. Soc. Trans.
15
754-759
1987
Aspergillus nidulans, Saccharomyces cerevisiae, Escherichia coli, Neurospora crassa
Van den Hombergh, J.P.T.W.; Moore, J.D.; Charles, I.G.
Overproduction in Escherichia coli of the dehydroquinate synthase domain of the Aspergillus nidulans pentafunctional AROM protein
Biochem. J.
284
861-867
1992
Aspergillus nidulans
-
Millar, G.; Coggins, J.R.
The complete amino acid sequence of 3-dehydroquinate synthase of Escherichia coli K12
FEBS Lett.
200
11-17
1986
Escherichia coli
Lambert, J.M.; Boocock, M.R.; Coggins, J.R.
The 3-dehydroquinate synthase activity of the pentafunctional arom enzyme complex of Neurospora crassa is Zn2+-dependent
Biochem. J.
226
817-829
1985
Neurospora crassa
Frost, J.W.; Bender, J.L.; Kadonaga, J.T.; Knowles, J.R.
Dehydroquinate synthase from Escherichia coli: Purification, cloning and construction of overproducers of the enzyme
Biochemistry
23
4470-4475
1984
Escherichia coli
Duncan, K.; Coggins, J.R.
Subcloning of the Escherichia coli genes aro A (5-enolyruvylshikimate 3-phosphate synthase) and aro B (3-dehydroquinate synthase)
Biochem. Soc. Trans.
12
274-275
1984
Escherichia coli
-
Yamamoto, E.
Purification and metal requirement of 3-dehydroquinate synthase from Phaseolus mungo seedlings
Phytochemistry
19
779-781
1980
Vigna mungo
-
LeMarechal, P.; Froussios, C.; Level, M.; Azerad, R.
The interaction of phosphonate and homophosphonate analogues of 3-deoxy-D-arabino heptulosonate 7-phosphate with 3-dehydroquinate synthetase from Escherichia coli
Biochem. Biophys. Res. Commun.
92
1104-1109
1980
Escherichia coli
Maitra, U.S.; Sprinson, D.B.
5-Dehydro-3-deoxy-D-arabino-heptulosonic acid 7-phosphate
J. Biol. Chem.
253
55426-5430
1978
Escherichia coli
-
Hasan, N.; Nester, E.W.
Dehydroquinate synthase in Bacillus subtilis. An enzyme associated with chorismate synthase and flavin reductase
J. Biol. Chem.
253
4999-5004
1978
Bacillus subtilis
Saijo, R.; Kosuge, T.
The conversion of 3-deoxyarabinoheptulosonate 7-phosphate to 3-dehydroquinate by Sorghum seedling preparations
Phytochemistry
17
223-225
1978
Sorghum sp.
-
Lumsden, J.; Coggins, J.R.
The subunit structure of the arom multienzyme complex of Neurospora crassa. A possible pentafunctional polypeptide chain
Biochem. J.
161
599-607
1977
Neurospora crassa
Gaertner, F.H.
Purification of two multienzyme complexes in the aromatic-tryptophan pathway of Neurospora crassa
Arch. Biochem. Biophys.
151
277-284
1972
Neurospora crassa
Srinivasan, P.R.; Rothschild, J.; Sprinson, D.B.
The enzymic conversion of 3-deoxy-D-arabino-heptulosonic acid 7-phosphate to 5-dehydroquinate
J. Biol. Chem.
238
3176-3182
1963
Escherichia coli
Moore, J.D.; Coggins, J.R.; Virden, R.; Hawkins, A.R.
Efficient independent activity of a monomeric, monofunctional dehydroquinate synthase derived from the N-terminus of the pentafunctional AROM protein of Aspergillus nidulans
Biochem. J.
301
297-304
1994
Aspergillus nidulans
Carpenter, E.P.; Hawkins, A.R.; Frost, J.W.; Browns, K.A.
Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis
Nature
394
299-302
1998
Aspergillus nidulans
Frost, J.W.; Piehler, L.T.; Montchamp, J.L.
In vitro and in vivo inhibition of dehydroquinate synthase
Biosynthesis and molecular regulation of amino acids in plants (Singh, B. K. ; Flores, H. E. ; Shannon, J. C eds. )
163-173
1992
Escherichia coli
-
Nichols, C.E.; Ren, J.; Lamb, H.; Haldane, F.; Hawkins, A.R.; Stammers, D.K.
Identification of many crystal forms of Aspergillus nidulans dehydroquinate synthase
Acta Crystallogr. Sect. D
57
306-309
2001
Aspergillus nidulans (P07547)
Nichols, C.E.; Hawkins, A.R.; Stammers, D.K.
Structure of the 'open' form of Aspergillus nidulans 3-dehydroquinate synthase at 1.7 A resolution from crystals grown following enzyme turnover
Acta Crystallogr. Sect. D
60
971-973
2004
Aspergillus nidulans (P07547), Aspergillus nidulans
Nichols, C.E.; Ren, J.; Leslie, K.; Dhaliwal, B.; Lockyer, M.; Charles, I.; Hawkins, A.R.; Stammers, D.K.
Comparison of ligand-induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases
J. Mol. Biol.
343
533-546
2004
Aspergillus nidulans (P07547), Staphylococcus aureus (Q6GGU4)
Park, A.; Lamb, H.K.; Nichols, C.; Moore, J.D.; Brown, K.A.; Cooper, A.; Charles, I.G.; Stammers, D.K.; Hawkins, A.R.
Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein
Protein Sci.
13
2108-2119
2004
Aspergillus nidulans
Sugahara, M.; Nodake, Y.; Sugahara, M.; Kunishima, N.
Crystal structure of dehydroquinate synthase from Thermus thermophilus HB8 showing functional importance of the dimeric state
Proteins
58
249-252
2004
Thermus thermophilus (P83703), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (P83703)
Ran, N.; Frost, J.W.
Directed evolution of 2-keto-3-deoxy-6-phosphogalactonate aldolase to replace 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase
J. Am. Chem. Soc.
129
6130-6139
2007
Escherichia coli (P07639), Escherichia coli
de Mendonca, J.D.; Ely, F.; Palma, M.S.; Frazzon, J.; Basso, L.A.; Santos, D.S.
Functional characterization by genetic complementation of aroB-encoded dehydroquinate synthase from Mycobacterium tuberculosis H37Rv and its heterologous expression and purification
J. Bacteriol.
189
6246-6252
2007
Mycobacterium tuberculosis (P9WPX9), Mycobacterium tuberculosis H37Rv (P9WPX9)
Ngo, P.H.; Natarajan, S.; Kim, H.; Hung, H.K.; Kim, J.; Lee, B.; Ahn, Y.; Kang, L.
Cloning, expression, crystallization and preliminary x-ray crystallographic analysis of 3-dehydroquinate synthase, Xoo1243, from Xanthomonas oryzae pv. oryzae
Acta Crystallogr. Sect. F
64
1128-1131
2008
Xanthomonas oryzae
Liu, J.S.; Cheng, W.C.; Wang, H.J.; Chen, Y.C.; Wang, W.C.
Structure-based inhibitor discovery of Helicobacter pylori dehydroquinate synthase
Biochem. Biophys. Res. Commun.
373
1-7
2008
Helicobacter pylori (P56081), Helicobacter pylori
Xie, J.; Tan, F.; Feng, W.; Chen, B.; Su, J.
Cloning of 3-dehydroquinate synthase cDNA from Echinacea angustifolia and its tissue expression characteristics
Chin. Tradit. Herbal Drugs
40
1967-1970
2009
Echinacea angustifolia (E6Y3G5)
-
De Mendonca, J.; Adachi, O.; Rosado, L.; Ducati, R.; Santos, D.; Basso, L.
Kinetic mechanism determination and analysis of metal requirement of dehydroquinate synthase from Mycobacterium tuberculosis H37Rv: An essential step in the function-based rational design of anti-TB drugs
Mol. Biosyst.
7
119-128
2011
Mycobacterium tuberculosis (P9WPX9), Mycobacterium tuberculosis H37Rv (P9WPX9)
Negron, L.; Parker, E.
Fluorinated substrates result in variable leakage of a reaction intermediate during catalysis by dehydroquinate synthase
Org. Biomol. Chem.
9
2861-2867
2011
Actinidia chinensis, Escherichia coli, Pyrococcus furiosus
Bender, S.; Mehdi, S.; Knowles, J.
Dehydroquinate synthase: The role of divalent metal cations and of nicotinamide adenine dinucleotide in catalysis
Biochemistry
28
7555-7560
1989
Escherichia coli, Escherichia coli RB791
Bender, S.; Widlanski, T.; Knowles, J.
Dehydroquinate synthase: The use of substrate analogues to probe the early steps of the catalyzed reaction
Biochemistry
28
7560-7572
1989
Escherichia coli, Escherichia coli RB791
Negron, L.; Patchett, M.L.; Parker, E.J.
Expression, purification, and characterisation of dehydroquinate synthase from Pyrococcus furiosus
Enzyme Res.
2011
134893
2011
Pyrococcus furiosus (Q8U0A8)
Mittelstaedt, G.; Negron, L.; Schofield, L.R.; Marsh, K.; Parker, E.J.
Biochemical and structural characterisation of dehydroquinate synthase from the New Zealand kiwifruit Actinidia chinensis
Arch. Biochem. Biophys.
537
185-191
2013
Actinidia chinensis
Isa, M.A.; Majumdhar, R.S.; Haider, S.
In silico docking and molecular dynamics simulation of 3-dehydroquinate synthase (DHQS) from Mycobacterium tuberculosis
J. Mol. Model.
24
132
2018
Mycobacterium tuberculosis (P9WPX9), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPX9)
Rapp, J.; Wagner, B.; Brilisauer, K.; Forchhammer, K.
In vivo inhibition of the 3-dehydroquinate synthase by 7-deoxysedoheptulose depends on promiscuous uptake by sugar transporters in cyanobacteria
Front. Microbiol.
12
692986
2021
Trichormus variabilis (Q3M4V2)
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