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Literature summary for 4.2.3.4 extracted from
- In silico docking and molecular dynamics simulation of 3-dehydroquinate synthase (DHQS) from Mycobacterium tuberculosis (2018), J. Mol. Model., 24, 132 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ZINC04113772 | - |
Mycobacterium tuberculosis |  |
| ZINC08983432 | - |
Mycobacterium tuberculosis | |
| ZINC11881196 | - |
Mycobacterium tuberculosis | |
| ZINC12243261 | - |
Mycobacterium tuberculosis | |
| ZINC12455413 | - |
Mycobacterium tuberculosis | |
| ZINC14743064 | - |
Mycobacterium tuberculosis | |
| ZINC14882944 | - |
Mycobacterium tuberculosis | |
| ZINC14986690 | - |
Mycobacterium tuberculosis | |
| ZINC18122756 | - |
Mycobacterium tuberculosis | |
| ZINC19334122 | - |
Mycobacterium tuberculosis | |
| ZINC20136483 | - |
Mycobacterium tuberculosis | |
| ZINC20779557 | - |
Mycobacterium tuberculosis | |
| ZINC633887 | - |
Mycobacterium tuberculosis | |
| ZINC633895 | - |
Mycobacterium tuberculosis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | activates | Mycobacterium tuberculosis | |
| Zn2+ | activates | Mycobacterium tuberculosis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate | Mycobacterium tuberculosis | - |
3-dehydroquinate + phosphate | - |
? | |
| 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate | Mycobacterium tuberculosis H37Rv | - |
3-dehydroquinate + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | P9WPX9 | - |
- |
| Mycobacterium tuberculosis H37Rv | P9WPX9 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate | - |
Mycobacterium tuberculosis | 3-dehydroquinate + phosphate | - |
? | |
| 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate | - |
Mycobacterium tuberculosis H37Rv | 3-dehydroquinate + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DHQS | - |
Mycobacterium tuberculosis |
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