BRENDA - Enzyme Database show
show all sequences of 4.2.3.4

The 3-dehydroquinate synthase activity of the pentafunctional arom enzyme complex of Neurospora crassa is Zn2+-dependent

Lambert, J.M.; Boocock, M.R.; Coggins, J.R.; Biochem. J. 226, 817-829 (1985)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
-
Neurospora crassa
bistrispropane
-
Neurospora crassa
Cu2+
-
Neurospora crassa
dithiothreitol
-
Neurospora crassa
EDTA
-
Neurospora crassa
Fe2+
-
Neurospora crassa
NADH
-
Neurospora crassa
Ni2+
-
Neurospora crassa
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0014
-
3-deoxy-D-arabino-heptulosonic acid 7-phosphate
-
Neurospora crassa
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Zn2+
-
Neurospora crassa
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Neurospora crassa
-
-
-
Purification (Commentary)
Commentary
Organism
arom-multienzyme complex
Neurospora crassa
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
-
Neurospora crassa
Storage Stability
Storage Stability
Organism
-20░C, more than 1 year
Neurospora crassa
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-deoxy-D-arabino-heptulosonic acid 7-phosphate
-
137628
Neurospora crassa
3-dehydroquinate + phosphate
-
137628
Neurospora crassa
-
3-deoxy-D-arabino-heptulosonic acid 7-phosphate
-
137628
Neurospora crassa 74-OR23-1A
3-dehydroquinate + phosphate
-
137628
Neurospora crassa 74-OR23-1A
-
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
19
-
3-deoxy-D-arabino-heptulosonic acid 7-phosphate
-
Neurospora crassa
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Neurospora crassa
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Neurospora crassa
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
-
Neurospora crassa
bistrispropane
-
Neurospora crassa
Cu2+
-
Neurospora crassa
dithiothreitol
-
Neurospora crassa
EDTA
-
Neurospora crassa
Fe2+
-
Neurospora crassa
NADH
-
Neurospora crassa
Ni2+
-
Neurospora crassa
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0014
-
3-deoxy-D-arabino-heptulosonic acid 7-phosphate
-
Neurospora crassa
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Zn2+
-
Neurospora crassa
Purification (Commentary) (protein specific)
Commentary
Organism
arom-multienzyme complex
Neurospora crassa
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
-
Neurospora crassa
Storage Stability (protein specific)
Storage Stability
Organism
-20░C, more than 1 year
Neurospora crassa
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-deoxy-D-arabino-heptulosonic acid 7-phosphate
-
137628
Neurospora crassa
3-dehydroquinate + phosphate
-
137628
Neurospora crassa
-
3-deoxy-D-arabino-heptulosonic acid 7-phosphate
-
137628
Neurospora crassa 74-OR23-1A
3-dehydroquinate + phosphate
-
137628
Neurospora crassa 74-OR23-1A
-
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
19
-
3-deoxy-D-arabino-heptulosonic acid 7-phosphate
-
Neurospora crassa
Other publictions for EC 4.2.3.4
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
748438
Isa
In silico docking and molecul ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Mol. Model.
24
132
2018
-
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14
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2
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2
-
8
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2
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14
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2
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2
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2
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-
-
-
-
-
-
-
-
-
-
-
729105
Mittelstaedt
Biochemical and structural cha ...
Actinidia chinensis
Arch. Biochem. Biophys.
537
185-191
2013
-
-
1
1
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-
1
-
4
4
-
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1
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1
1
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1
1
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2
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1
2
1
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1
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4
4
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-
1
1
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-
1
1
-
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-
716188
De Mendonca
Kinetic mechanism determinatio ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Mol. Biosyst.
7
119-128
2011
-
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1
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4
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
716413
Negron
Fluorinated substrates result ...
Actinidia chinensis, Escherichia coli, Pyrococcus furiosus
Org. Biomol. Chem.
9
2861-2867
2011
-
-
3
-
-
-
-
9
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-
3
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3
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9
3
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9
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3
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9
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3
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9
3
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9
-
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9
9
722147
Negron
Expression, purification, and ...
Pyrococcus furiosus
Enzyme Res.
2011
134893
2011
-
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1
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-
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1
1
-
4
2
1
-
1
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1
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2
1
-
1
1
1
1
1
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1
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-
1
-
1
-
4
2
1
-
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-
1
-
-
-
-
2
1
-
1
1
1
1
1
-
-
-
1
1
-
1
1
703232
Xie
-
Cloning of 3-dehydroquinate sy ...
Echinacea angustifolia
Chin. Tradit. Herbal Drugs
40
1967-1970
2009
-
-
1
-
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1
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2
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1
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2
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-
690254
Ngo
Cloning, expression, crystalli ...
Xanthomonas oryzae
Acta Crystallogr. Sect. F
64
1128-1131
2008
-
1
1
1
-
-
-
-
-
-
-
2
-
4
-
-
1
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-
1
-
2
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-
1
-
-
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-
1
1
1
1
-
-
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-
-
2
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690739
Liu
Structure-based inhibitor disc ...
Helicobacter pylori
Biochem. Biophys. Res. Commun.
373
1-7
2008
-
1
1
1
-
-
3
-
-
1
-
1
-
5
-
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1
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1
1
1
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-
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1
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1
1
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2
-
1
1
1
1
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2
3
1
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1
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1
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1
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1
1
1
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1
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680370
Ran
Directed evolution of 2-keto-3 ...
Escherichia coli
J. Am. Chem. Soc.
129
6130-6139
2007
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1
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2
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15
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1
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1
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15
-
1
-
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-
1
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-
-
-
-
-
-
-
-
680499
de Mendonca
Functional characterization by ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Bacteriol.
189
6246-6252
2007
-
1
1
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2
2
2
-
4
-
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1
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-
-
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2
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1
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1
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1
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1
1
1
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2
2
2
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1
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2
-
1
-
-
-
1
-
-
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-
649245
Nichols
Structure of the 'open' form o ...
Aspergillus nidulans
Acta Crystallogr. Sect. D
60
971-973
2004
-
-
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1
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2
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1
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666031
Nichols
Comparison of ligand-induced c ...
Aspergillus nidulans, Staphylococcus aureus
J. Mol. Biol.
343
533-546
2004
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2
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2
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2
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2
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666849
Park
Biophysical and kinetic analys ...
Aspergillus nidulans
Protein Sci.
13
2108-2119
2004
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-
1
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4
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1
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2
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2
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1
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1
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4
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2
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2
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1
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666871
Sugahara
Crystal structure of dehydroqu ...
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Proteins
58
249-252
2004
1
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1
1
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1
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2
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1
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649156
Nichols
Identification of many crystal ...
Aspergillus nidulans
Acta Crystallogr. Sect. D
57
306-309
2001
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1
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1
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137643
Carpenter
Structure of dehydroquinate sy ...
Aspergillus nidulans
Nature
394
299-302
1998
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137622
Bereswill
Cloning and functional charact ...
Helicobacter pylori
Med. Microbiol. Immunol.
186
125-134
1997
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1
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6
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137641
Moore
Efficient independent activity ...
Aspergillus nidulans
Biochem. J.
301
297-304
1994
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2
2
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1
1
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1
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1
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1
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2
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2
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1
1
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1
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1
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1
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5486
Euverink
Purification and characterizat ...
Amycolatopsis methanolica
J. Gen. Microbiol.
138
2449-2457
1992
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137625
Van den Hombergh
-
Overproduction in Escherichia ...
Aspergillus nidulans
Biochem. J.
284
861-867
1992
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1
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1
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1
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1
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1
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137644
Frost
-
In vitro and in vivo inhibitio ...
Escherichia coli
Biosynthesis and molecular regulation of amino acids in plants (Singh, B. K. ; Flores, H. E. ; Shannon, J. C eds. )
163-173
1992
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1
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137619
Myrvold
-
Chemical inhibition of dehydro ...
Escherichia coli
J. Am. Chem. Soc.
111
1861-1866
1989
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4
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1
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1
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137620
Pompliano
-
Probing lethal metabolic pertu ...
Pisum sativum
J. Am. Chem. Soc.
111
1866-1871
1989
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2
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1
1
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1
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1
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1
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1
1
1
1
-
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-
718818
Bender
Dehydroquinate synthase: The r ...
Escherichia coli, Escherichia coli RB791
Biochemistry
28
7555-7560
1989
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-
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1
2
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7
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5
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2
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1
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7
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1
2
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1
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718819
Bender
Dehydroquinate synthase: The u ...
Escherichia coli, Escherichia coli RB791
Biochemistry
28
7560-7572
1989
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7
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1
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5
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2
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7
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2
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137621
Matsui
-
Cloning of a gene cluster of a ...
Corynebacterium glutamicum
Agric. Biol. Chem.
52
525-531
1988
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-
1
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1
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137623
Mehdi
Dehydroquinate synthase from E ...
Escherichia coli
Methods Enzymol.
142
306-314
1987
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-
1
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1
1
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2
1
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1
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1
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1
1
2
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1
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1
1
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2
1
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1
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1
1
2
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-
137624
Coggins
The anatomy of a multifunction ...
Aspergillus nidulans, Escherichia coli, Neurospora crassa, Saccharomyces cerevisiae
Biochem. Soc. Trans.
15
754-759
1987
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1
2
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4
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4
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3
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4
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-
137626
Millar
The complete amino acid sequen ...
Escherichia coli
FEBS Lett.
200
11-17
1986
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-
1
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1
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3
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5475
Mousdale
Subcellular localization of th ...
Pisum sativum
Planta
163
241-249
1985
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1
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1
1
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-
137628
Lambert
The 3-dehydroquinate synthase ...
Neurospora crassa
Biochem. J.
226
817-829
1985
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-
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8
1
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1
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2
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1
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1
1
2
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1
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1
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8
-
1
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1
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1
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1
1
2
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1
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-
-
137629
Frost
Dehydroquinate synthase from E ...
Escherichia coli
Biochemistry
23
4470-4475
1984
-
-
1
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1
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1
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1
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1
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1
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1
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1
1
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1
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1
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-
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-
137630
Duncan
-
Subcloning of the Escherichia ...
Escherichia coli
Biochem. Soc. Trans.
12
274-275
1984
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-
1
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1
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1
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-
5468
Bode
Aggregation und Trennbarkeit d ...
Cyberlindnera fabianii, Cyberlindnera jadinii, Hansenula henricii, Lodderomyces elongisporus, Meyerozyma guilliermondii, Neurospora crassa, Rhodotorula mucilaginosa, Rhodotorula sphaerocarpa, Rhodotorula toruloides, Saccharomyces cerevisiae, Saccharomycopsis lipolytica, Wickerhamomyces anomalus
Z. Allg. Mikrobiol.
21
417-422
1981
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18
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12
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18
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-
-
137632
Yamamoto
-
Purification and metal require ...
Vigna mungo
Phytochemistry
19
779-781
1980
-
-
-
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1
1
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1
2
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1
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1
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1
1
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1
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1
2
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1
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1
1
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-
137633
LeMarechal
The interaction of phosphonate ...
Escherichia coli
Biochem. Biophys. Res. Commun.
92
1104-1109
1980
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-
-
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4
1
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2
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1
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1
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4
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1
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1
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-
5467
Saijo
Some properties of the initial ...
Camellia sinensis
Agric. Biol. Chem.
43
1427-1432
1979
-
-
-
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-
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3
-
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1
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1
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1
1
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1
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1
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3
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1
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1
1
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-
-
137635
Maitra
-
5-Dehydro-3-deoxy-D-arabino-he ...
Escherichia coli
J. Biol. Chem.
253
55426-5430
1978
-
-
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4
1
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1
1
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1
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1
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1
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1
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1
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1
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4
-
1
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1
1
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1
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1
-
-
1
-
-
-
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-
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-
-
-
-
-
-
-
137636
Hasan
Dehydroquinate synthase in Bac ...
Bacillus subtilis
J. Biol. Chem.
253
4999-5004
1978
-
-
-
-
-
-
4
2
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2
1
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1
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1
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1
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-
3
-
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1
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1
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4
-
2
-
2
1
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1
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1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
137637
Saijo
-
The conversion of 3-deoxyarabi ...
Sorghum sp.
Phytochemistry
17
223-225
1978
-
-
-
-
-
-
2
-
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1
1
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1
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1
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1
1
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1
1
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1
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1
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2
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1
1
-
-
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1
-
1
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
137638
Lumsden
The subunit structure of the a ...
Neurospora crassa
Biochem. J.
161
599-607
1977
-
-
-
-
-
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2
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1
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1
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1
1
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1
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2
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1
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1
1
-
1
-
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-
-
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-
-
-
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-
137639
Gaertner
Purification of two multienzym ...
Neurospora crassa
Arch. Biochem. Biophys.
151
277-284
1972
-
-
-
-
-
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1
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1
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1
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1
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1
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-
-
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-
137640
Srinivasan
The enzymic conversion of 3-de ...
Escherichia coli
J. Biol. Chem.
238
3176-3182
1963
-
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1
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1
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1
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1
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1
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1
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1
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