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Literature summary for 4.2.3.4 extracted from

  • Bender, S.; Widlanski, T.; Knowles, J.
    Dehydroquinate synthase: The use of substrate analogues to probe the early steps of the catalyzed reaction (1989), Biochemistry, 28, 7560-7572.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
[(1R)-(1alpha,3beta,4alpha ,5beta)]-5-(2-phosphonoethyl)-1,3,4-trihydroxycyclohexane-1-carboxylic acid
-
Escherichia coli
[(1R)-(1alpha,3beta,4alpha,5beta)]-1,4,5-trihydroxy-3-(phosphonooxy)-cyclohexane-1-carboxylate
-
Escherichia coli
[(1R)-(1alpha,3beta,4alpha,5beta)]-5-(E)-(2-phosphonoethenyl)-1,3,4-trihydroxycyclohexane-1-carboxylic acid
-
Escherichia coli
[(1R)-(1alpha,3beta,4alpha,5beta)]-5-(phosphonomethyl)-1,3,4-trihydroxycyclohexane-1-carboxylic acid slow binding inhibitor Escherichia coli
[(1R)-(1alpha,3beta,4alpha,5beta)]-5-(Z)-(2-phosphonoethenyl)-1,3,4-trihydroxycyclohexane-1-carboxylic acid
-
Escherichia coli
[(2R)-(2alpha,4beta,5alpha,6beta)]-6-(2-phosphonoethyl)-2,4,5-trihydroxytetrahydropyran-2-carboxylate
-
Escherichia coli
[(2R)-(2alpha,4beta,5alpha,6beta)]-6-(phosphonomethyl)-2,4,5-trihydroxytetrahydropyran-2-carboxylate
-
Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ required Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli RB791
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate
-
Escherichia coli 3-dehydroquinate + phosphate
-
?
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate
-
Escherichia coli RB791 3-dehydroquinate + phosphate
-
?

Synonyms

Synonyms Comment Organism
dehydroquinate synthase
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Escherichia coli