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Information on EC 4.2.1.167 - (R)-2-hydroxyglutaryl-CoA dehydratase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.167 (R)-2-hydroxyglutaryl-CoA dehydratase
IUBMB Comments
The enzymes from the bacteria Acidaminococcus fermentans and Clostridium symbiosum are involved in the fermentation of L-glutamate. The enzyme contains [4F-4S] clusters, FMNH2 and riboflavin. It must be activated by an activator protein. Once activated, it can catalyse many turnovers.
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The enzyme appears in viruses and cellular organisms
Synonyms
hgdAB, HgdC, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-2-hydroxyglutaryl-CoA = (E)-glutaconyl-CoA + H2O
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