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C552A
-
site-directed mutagenesis, the mutant shows similar cleavage by caspase-9 as the wild-type enzyme
D517A
-
site-directed mutagenesis, the mutant shows reduced cleavage by caspase-9 compared to the wild-type enzyme
D518A
-
site-directed mutagenesis, the mutant shows reduced cleavage by caspase-9 compared to the wild-type enzyme
D518A/D550A/D551A
-
site-directed mutagenesis, the mutant shows highly reduced activation by butyrate compared to the wild-type enzyme
D547A
-
site-directed mutagenesis, the mutant shows reduced cleavage by caspase-9 compared to the wild-type enzyme
D547A/P548A/F549A
-
site-directed mutagenesis, the mutant shows highly reduced cleavage by caspase-9 compared to the wild-type enzyme
D550A
-
site-directed mutagenesis, the mutant shows reduced cleavage by caspase-9 compared to the wild-type enzyme
D550A/D551A
-
site-directed mutagenesis, the mutant shows highly reduced cleavage by caspase-9 compared to the wild-type enzyme
D550A/D551A/C552A
-
site-directed mutagenesis, the mutant shows highly reduced cleavage by caspase-9 compared to the wild-type enzyme
D551A
-
site-directed mutagenesis, the mutant shows reduced cleavage by caspase-9 compared to the wild-type enzyme
F549A
-
site-directed mutagenesis, the mutant shows reduced cleavage by caspase-9 compared to the wild-type enzyme
I525A
-
site-directed mutagenesis, the mutant shows reduced cleavage by caspase-9 compared to the wild-type enzyme
K524A
-
site-directed mutagenesis, the mutant shows reduced cleavage by caspase-9 compared to the wild-type enzyme
K527A
-
site-directed mutagenesis, the mutant shows reduced cleavage by caspase-9 compared to the wild-type enzyme
P519A
-
site-directed mutagenesis, the mutant shows reduced cleavage by caspase-9 compared to the wild-type enzyme
P548A
-
site-directed mutagenesis, the mutant shows reduced cleavage by caspase-9 compared to the wild-type enzyme
Q521A
-
site-directed mutagenesis, the mutant shows similar cleavage by caspase-9 as the wild-type enzyme
R523A
-
site-directed mutagenesis, the mutant shows reduced cleavage by caspase-9 compared to the wild-type enzyme
T544A/M545A/P546A
-
site-directed mutagenesis, the mutant shows highly reduced cleavage by caspase-9 compared to the wild-type enzyme
additional information
-
construction of deletion mutants with altered activation by butyrate and cleavage by caspase-9, overview
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Aures, D.; Hakanson, R.
Histidine decarboxylase (mammalian)
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Mus musculus, Rattus norvegicus
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brenda
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Purification and characterization of histidine decarboxylase from mouse kidney
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Mus musculus
brenda
Yamamoto, J.; Fukui, T.; Suzuki, K.; Tanaka, S.; Yatsunami, K.; Ichikawa, A.
Expression and characterization of recombinant mouse mastocytoma histidine decarboxylase
Biochim. Biophys. Acta
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431-40
1993
Mus musculus
brenda
Kinoshita, E.; Saito, M.
Novel histamine measurement by HPLC analysis used to assay histidine decarboxylase inhibitory activity of shoyuflavones
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62
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1998
Clostridium perfringens, Mus musculus
brenda
Ohmori, E.; Fukui, T.; Imanishi, N.; Yatsunami, K.; Ichikawa, A.
Purification and characterization of L-histidine decarboxylase from mouse mastocytoma P-815 cells
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Mus musculus
brenda
Watabe, A.; Fukui, T.; Ohmori, E.; Ichikawa, A.
Purification and properties of L-histidine decarboxylase from mouse stomach
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43
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1992
Mus musculus
brenda
Hirasawa, N.; Murakami, A.; Ohuchi, K.
Expression of 74-kDa histidine decarboxylase protein in a macrophage-like cell line RAW 264.7 and inhibition by dexamethasone
Eur. J. Pharmacol.
418
23-28
2001
Mus musculus
brenda
Ayada, K.; Oguri, S.; Yamaguchi, K.; Kumagai, K.; Endo, Y.
Elevation of histidine decarboxylase activity in the stomach of mice by ulcerogenic drugs
Eur. J. Pharmacol.
460
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2003
Mus musculus
brenda
Yamaguchi, K.; Motegi, K.; Kurimoto, M.; Endo, Y.
Induction of the activity of the histamine-forming enzyme, histidine decarboxylase, in mice by IL-18 and by IL-18 plus IL-12
Inflamm. Res.
49
513-519
2000
Mus musculus
brenda
Safina, F.; Tanaka, S.; Inagaki, M.; Tsuboi, K.; Sugimoto, Y.; Ichikawa, A.
Expression of L-histidine decarboxylase in mouse male germ cells
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277
14211-14215
2002
Mus musculus
brenda
Wagner, W.; Fogel, W.A.
Mammary histidine decarboxylase vulnerability to enzyme antisense oligonucleotides: histamine and polyamine systems cross-talk
Amino Acids
26
311-316
2004
Mus musculus (P23738), Mus musculus
brenda
Tanaka, S.; Deai, K.; Konomi, A.; Takahashi, K.; Yamane, H.; Sugimoto, Y.; Ichikawa, A.
Expression of L-histidine decarboxylase in granules of elicited mouse polymorphonuclear leukocytes
Eur. J. Immunol.
34
1472-1482
2004
Mus musculus
brenda
Pos, Z.; Mller, K.; Novalphak, I.; Buzas, E.; Solbach, W.; Falus, A.; Laskay, T.
Different patterns of the L-histidine decarboxylase (HDC) gene expression in mice resistant and susceptible to experimental cutaneous leishmaniasis
Inflamm. Res.
53
38-43
2004
Mus musculus
brenda
Fogel, W.A.; Dudkowska, M.; Wagner, W.; Grzelakowska-Sztabert, B.; Manteuffel-Cymborowska, M.
Ornithine and histidine decarboxylase: Activities in hypertrophic and hyperplastic mouse kidney
Inflamm. Res.
54
S62-S63
2005
Mus musculus
-
brenda
Shoji, N.; Yoshida, A.; Yu, Z.; Endo, Y.; Sasano, T.
Lipopolysaccharide stimulates histamine-forming enzyme (histidine decarboxylase) activity in murine dental pulp and gingiva
Arch. Oral Biol.
51
856-860
2006
Mus musculus
brenda
Furuta, K.; Ichikawa, A.; Nakayama, K.; Tanaka, S.
Membrane orientation of the precursor 74-kDa form of L-histidine decarboxylase
Inflamm. Res.
55
185-191
2006
Mus musculus
brenda
Deng, X.; Wu, X.; Yu, Z.; Arai, I.; Sasano, T.; Sugawara, S.; Endo, Y.
Inductions of histidine decarboxylase in mouse tissues following systemic antigen challenge: contributions made by mast cells, non-mast cells and IL-1
Int. Arch. Allergy Immunol.
144
69-78
2007
Mus musculus
brenda
Furuta, K.; Nakayama, K.; Sugimoto, Y.; Ichikawa, A.; Tanaka, S.
Activation of histidine decarboxylase through post-translational cleavage by caspase-9 in a mouse mastocytoma P-815
J. Biol. Chem.
282
13438-13446
2007
Mus musculus, Mus musculus BDF1
brenda
Okigami, H.; Ueno, H.
Bioinformatic study on histidine decarboxylase
J. Biol. Macromol.
6
11-27
2006
Morganella morganii (P05034), Rattus norvegicus (P16453), Homo sapiens (P19113), Klebsiella aerogenes (P28577), Raoultella planticola (P28578), Solanum lycopersicum (P54772), Pseudomonas fluorescens (P95477), Drosophila melanogaster (Q05733), Vibrio anguillarum (Q56581), Vibrio anguillarum (Q79JY8), Gloeobacter violaceus (Q7NIG4), Mus musculus (Q7TMW5), Photobacterium phosphoreum (Q846V2), Aplysia californica (Q86BW8), Clostridium tetani (Q894Q7), Oryza sativa (Q8RV06), Mesorhizobium loti (Q98A07), Arabidopsis thaliana (Q9MA74)
-
brenda
Pessler, F.; Mayer, C.T.; Jung, S.M.; Behrens, E.M.; Dai, L.; Menetski, J.P.; Schumacher, H.R.
Identification of novel monosodium urate crystal regulated mRNAs by transcript profiling of dissected murine air pouch membranes
Arthritis Res. Ther.
10
R64
2008
Mus musculus (P23738), Mus musculus
brenda
Suzuki, E.; Ninomiya, Y.; Umezawa, K.
Induction of histidine decarboxylase in macrophages inhibited by the novel NF-kappaB inhibitor (-)-DHMEQ
Biochem. Biophys. Res. Commun.
379
379-383
2009
Mus musculus
brenda
Zhao, C.; Martinez, V.; Piqueras, L.; Wang, L.; Tache, Y.; Chen, D.
Control of gastric acid secretion in somatostatin receptor 2 deficient mice: shift from endocrine/paracrine to neurocrine pathways
Endocrinology
149
498-505
2008
Mus musculus
brenda
Szebeni, A.; Prohaszka, Z.; Buzas, E.; Falus, A.; Kecskemeti, V.
Effects of vaccination with heat shock proteins on streptozotocin induced diabetes in histidine decarboxylase knockout mice
Inflamm. Res.
57
178-182
2008
Mus musculus
brenda
Beghdadi, W.; Porcherie, A.; Schneider, B.S.; Dubayle, D.; Peronet, R.; Huerre, M.; Watanabe, T.; Ohtsu, H.; Louis, J.; Mecheri, S.
Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease
J. Exp. Med.
205
395-408
2008
Mus musculus
brenda
Leite-de-Moraes, M.C.; Diem, S.; Michel, M.L.; Ohtsu, H.; Thurmond, R.L.; Schneider, E.; Dy, M.
Cutting edge: Histamine receptor H4 activation positively regulates in vivo IL-4 and IFN-gamma production by invariant NKT cells
J. Immunol.
182
1233-1236
2009
Mus musculus
brenda
Davis, S.C.; Clark, S.; Hayes, J.R.; Green, T.L.; Gruetter, C.A.
Up-regulation of histidine decarboxylase expression and histamine content in B16F10 murine melanoma cells
Inflamm. Res.
60
55-61
2011
Mus musculus
brenda
Funayama, H.; Huang, L.; Asada, Y.; Endo, Y.; Takada, H.
Enhanced induction of a histamine-forming enzyme, histidine decarboxylase, in mice primed with NOD1 or NOD2 ligand in response to various Toll-like receptor agonists
Innate Immun.
16
265-272
2010
Mus musculus
brenda
Krusong, K.; Ercan-Sencicek, A.G.; Xu, M.; Ohtsu, H.; Anderson, G.M.; State, M.W.; Pittenger, C.
High levels of histidine decarboxylase in the striatum of mice and rats
Neurosci. Lett.
495
110-114
2011
Mus musculus, Rattus norvegicus
brenda
Pino-Angeles, A.; Morreale, A.; Negri, A.; Sanchez-Jimenez, F.; Moya-Garcia, A.
Substrate uptake and protein stability relationship in mammalian histidine decarboxylase
Proteins
78
154-161
2010
Mus musculus
brenda
Ayada, K.; Tsuchiya, M.; Yoneda, H.; Yamaguchi, K.; Kumamoto, H.; Sasaki, K.; Tadano, T.; Watanabe, M.; Endo, Y.
Induction of the histamine-forming enzyme histidine decarboxylase in skeletal muscles by prolonged muscular work histological demonstration and mediation by cytokines
Biol. Pharm. Bull.
40
1326-1330
2017
Mus musculus (P23738), Mus musculus BALB/c (P23738)
brenda