EC Number   |
Application |
Reference |
|---|
    4.1.1.22 | diagnostics |
HDC can be used as an immunohistochemical marker for the detection of immature neoplastic mast cells in patients with mast cell-proliferative disorders |
680088 |
| 4.1.1.22 | drug development |
HDC is a potential target to attenuate histamine production in certain pathological states using structure-based inhibitors, design, synthesis, and test of potentially membrane-permeable pyridoxyl-substrate conjugates as inhibitors for human HDC and modeling of an active site for hHDC, which is compatible with the experimental data, overview |
679733 |
| 4.1.1.22 | medicine |
confirmatory test for identification of Enterobacter aerogenes |
665830 |
| 4.1.1.22 | medicine |
histamine-mediated signaling contributes to malaria pathogenesis, histidine decarboxylase-deficient mice are highly resistant to severe malaria and display resistance to Plasmodium berghei strains ANKA and NK65 |
693426 |
| 4.1.1.22 | medicine |
histidine decarboxylase-deficient mice present a numerical and functional deficit in invariant NK T cells as evidenced by a drastic decrease of IL-4 and IFN-gamma production |
693469 |
| 4.1.1.22 | medicine |
loss of HDC is a marker of malignant transformation and dedifferentiation of B-cells infiltrating the skin |
690301 |
| 4.1.1.22 | medicine |
suppression of histamine signaling by inhibition of HDC may be a novel target of probiotics in preventing allergic diseases |
693829 |
| 4.1.1.22 | nutrition |
dairy products must be dedicated to a thorough risk analysis and development of strategies to contrast the presence of histaminogenic Streptococcus thermophilus strains in products from raw or mildly heat-treated milk. The HdcA enzyme in crude cell-free extracts is mostly active at acidic pH values common in dairy products. NaCl concentrations lower than 5% do not affect its activity. The enzyme is quite resistant to heat treatments resembling low pasteurization, but is inactivated at 75°C for 2 min |
-, 728063 |
