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Literature summary for 4.1.1.22 extracted from

  • Dev, S.; Mizuguchi, H.; Das, A.K.; Matsushita, C.; Maeyama, K.; Umehara, H.; Ohtoshi, T.; Kojima, J.; Nishida, K.; Takahashi, K.; Fukui, H.
    Suppression of histamine signaling by probiotic Lac-B: a possible mechanism of its anti-allergic effect (2008), J. Pharmacol. Sci., 107, 159-166.
    View publication on PubMed
Search for more literature for 4.1.1.22

Activating Compound

Activating Compound Comment Organism Structure
toluene 2,4-diisocyanate toluene 2,4-diisocyanate provocation causes acute allergy-like behaviors along with significant up-regulation of HDC mRNA expression and increased HDC activity Rattus norvegicus

Application

Application Comment Organism
medicine suppression of histamine signaling by inhibition of HDC may be a novel target of probiotics in preventing allergic diseases Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information Lac-B (a mixture of freeze-dried Bifidobacterium infantis and Bifidobacterium longum) shows significant anti-allergic effect through suppression of both H1R and HDC gene expression followed by decrease in H1R, HDC protein level, and histamine content, oral administration of the Lac-B suspension significantly suppresses the toluene 2,4-diisocyanate-induced HDC mRNA up-regulation Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
nasal mucosa
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidine
-
 Rattus norvegicus histamine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
HDC
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus