Information on EC 3.5.4.37 - double-stranded RNA adenine deaminase

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EC Tree
IUBMB Comments
This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity .
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Word Map
  • 3.5.4.37
  • inosine
  • a-to-i
  • deaminases
  • deamination
  • adenosine-to-inosine
  • hereditaria
  • pre-mrnas
  • rna-editing
  • dyschromatosis
  • symmetrica
  • z-dna
  • duplex
  • ampa
  • glur-b
  • unedited
  • left-handed
  • recoding
  • mda5
  • interferon-inducible
  • macules
  • site-selective
  • hypopigmented
  • ifn-inducible
  • rig-i
  • interferon-stimulated
  • dicer
  • ifn-stimulated
  • ca2+-permeable
  • dsrbds
  • 5-ht2cr
  • pigmentary
  • hypermutation
  • interferonopathy
  • samhd1
  • genodermatosis
  • inosine-containing
  • medicine
  • drug development
  • dsrna-binding
  • autoinflammatory
  • antigenome
  • protein-rna
The enzyme appears in viruses and cellular organisms
Reaction Schemes
adenine in double-stranded RNA
+
=
hypoxanthine in double-stranded RNA
+
Synonyms
ADAR, ADAR1, ADAR1L, ADAR1S, ADAR2, ADAR2 deaminase, adenosine deaminase acting on RNA 1, adenosine deaminase acting on RNA-1, APOBEC1, bADAR1a, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
adenine in double-stranded RNA + H2O = hypoxanthine in double-stranded RNA + NH3
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