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Literature summary for 3.5.4.37 extracted from

  • Källman, A.M.; Sahlin, M.; Ohman, M.
    ADAR2 A->I editing: site selectivity and editing efficiency are separate events (2003), Nucleic Acids Res., 31, 4874-4881.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.37

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
adenine in double-stranded RNA + H2O Rattus norvegicus
-
 hypoxanthine in double-stranded RNA + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenine in double-stranded RNA + H2O
-
 Rattus norvegicus hypoxanthine in double-stranded RNA + NH3
-
 ?
adenine in double-stranded RNA + H2O pre-mRNA of glutamate receptor subunit B. ADAR2 selectively edits the R/G site (R/G stem-loop), while ADAR1 edits more promiscuously at several other adenosines in the double-stranded stem. The immediate structure surrounding the editing site is important. A purine opposite to the editing site has a negative effect on both selectivity and efficiency of editing. More distant internal loops in the substrate have minor effects on site selectivity, while efficiency of editing is influenced. Changes in the RNA structure that affected editing do not alter the binding abilities of ADAR2. Binding and catalysis are independent events Rattus norvegicus hypoxanthine in double-stranded RNA + NH3
-
 ?

Synonyms

Synonyms Comment Organism
ADAR1
-
 Rattus norvegicus
ADAR2
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Rattus norvegicus