Literature summary for 3.5.4.37 extracted from

Song, C.; Sakurai, M.; Shiromoto, Y.; Nishikura, K.
Functions of the RNA editing enzyme ADAR1 and their relevance to human diseases (2016), Genes (Basel), 7, E129 .

Search for more literature for 3.5.4.37

Application

Application	Comment	Organism
medicine	the levels of RNA editing by ADAR1 can serve as new tools for diagnosis in cancer stem cell-related illnesses. In situations where ADAR1 overexpression contributes to disease progression, as in several cancers, or where ADAR1 interacts with other proteins in editing-independent manners, inhibition of ADAR1 could potentially be another strategy in treatment	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P55265	-	-

Synonyms

Synonyms	Comment	Organism
ADAR1	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	ADAR1 is an essential enzyme for normal development. The interferon-inducible ADAR1p150 is involved in immune responses to both exogenous and endogenous triggers, whereas the functions of the constitutively expressed ADAR1p110 are variable. ADAR1 is involved in the recognition of self versus non-self dsRNA. This provides potential explanations for its links to hematopoiesis, type I interferonopathies, and viral infections. Editing in both coding and noncoding sequences results in diseases ranging from cancers to neurological abnormalities. Furthermore, editing of noncoding sequences, like microRNAs, can regulate protein expression, while editing of Alu sequences can affect translational efficiency and editing of proximal sequences. Identifications of long noncoding RNA and retrotransposons as editing targets expand the effects of A-to-I editing. Besides editing, ADAR1 also interacts with other dsRNA-binding proteins in editing-independent manners	Homo sapiens

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Release 2023.1 (January 2023)