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Information on EC 3.5.1.9 - arylformamidase
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3.5.1.9 arylformamidaseIUBMB Comments
Also acts on other aromatic formylamines.
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Word Map
- 3.5.1.9
-
organophosphorus
- l-tryptophan
-
formylation
-
teratogen
- n-formyl-l-kynurenine
-
teratogenesis
- methylcarbamate
- l-kynurenine
- diazinon
- parvulus
-
pyrimidinyls
-
kynurenic
-
xanthurenic
-
triesters
- degradation
-
formyltransferase
- crotonamide
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
kynurenine formamidase, afmid, formylase, kfase, formamidase i, formamidase ii, arylformamidase, formylkynurenine formamidase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AFMID
formamidase I
-
-
-
-
formamidase II
-
-
-
-
formylase
-
-
-
-
formylkynureninase
-
-
-
-
formylkynurenine formamidase
KFA
KFase
KynB
kynurenine formamidase
kynurine formamidase
-
-
-
-
formylkynurenine formamidase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
N-formyl-L-kynurenine + H2O = formate + L-kynurenine
also acts on other aromatic formylamines
-
-
-
N-formyl-L-kynurenine + H2O = formate + L-kynurenine
the catalytic triad is formed by residues Ser162, Asp247, and His279
N-formyl-L-kynurenine + H2O = formate + L-kynurenine
the presence of a bridging water/hydroxide ligand in conjunction with the placement of an active site histidine supports a distinctive amidation mechanism, proposed mechanism with intermediate state, overview
N-formyl-L-kynurenine + H2O = formate + L-kynurenine
the presence of a bridging water/hydroxide ligand in conjunction with the placement of an active site histidine supports a distinctive amidation mechanism, proposed mechanism with intermediate state, overview
N-formyl-L-kynurenine + H2O = formate + L-kynurenine
the presence of a bridging water/hydroxide ligand in conjunction with the placement of an active site histidine supports a distinctive amidation mechanism, proposed mechanism with intermediate state, overview
N-formyl-L-kynurenine + H2O = formate + L-kynurenine
via tetrahedral intermediate, enzyme structure and catalytic mechanism, overview
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
carboxylic acid amide hydrolysis
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
aryl-formylamine amidohydrolase
Also acts on other aromatic formylamines.
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CAS REGISTRY NUMBER
COMMENTARY
156229-75-3
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-chloro-N-(1-naphthyl)acetamide + H2O
chloroacetate + 1-naphthylamine
-
low activity
-
?
5-hydroxyformyl-DL-kynurenine + H2O
5-hydroxy-DL-kynurenine + formate
-
-
-
?
acetanilide + H2O
acetate + aniline
-
formation of alcohol esters in the presence of alcohols
-
?
N-acetylanthranilic acid + H2O
acetate + anthranilic acid
-
formation of alcohol esters in the presence of alcohols
-
?
N-formyl-2-aminobenzenesulfonic acid + H2O
formate + 2-aminobenzenesulfonic acid
-
low activity
-
?
N-formyl-m-aminobenzoic acid + H2O
formate + m-aminobenzoic acid
-
very low activity
-
?
N-formyl-o-aminonitrobenzene + H2O
formate + o-nitroaniline
-
low activity
-
?
N-formylnitroaniline + H2O
formate + nitroaniline
-
low activity
-
?
additional information
?
-
-
an enzyme other than the aryl formamidase additionally catalyzes the formation of L-kynurenine in kidney
-
-
?
N-formyl-4-(methylamino)-benzoic acid + H2O
4-methylaminobenzoic acid + formate
-
-
-
-
?
N-formyl-4-(methylamino)-benzoic acid + H2O
4-methylaminobenzoic acid + formate
-
-
-
-
?
N-formyl-DL-kynurenine + H2O
L-kynurenine + formate + N-formyl-D-kynurenine
-
mixture of equal amounts of D- and L-kynurenine
N-formyl-D-kynurenine might inhibit activity
?
N-formyl-DL-kynurenine + H2O
L-kynurenine + formate + N-formyl-D-kynurenine
-
mixture of equal amounts of D- and L-kynurenine
N-formyl-D-kynurenine might inhibit activity
?
N-formyl-L-kynurenine + H2O
formate + L-kynurenine
the enzyme forms part of the kynurenine pathway which metabolises tryptophan to anthranilate
-
-
?
N-formyl-L-kynurenine + H2O
formate + L-kynurenine
-
-
-
?
N-formyl-L-kynurenine + H2O
formate + L-kynurenine
the enzyme forms part of the kynurenine pathway which metabolises tryptophan to anthranilate
-
-
?
N-formyl-L-kynurenine + H2O
formate + L-kynurenine
analysis of enzyme-substrate complex structure using the crystal structure of enzyme-inhibitor PMSF complex and molecular docking, overview
-
-
?
N-formyl-L-kynurenine + H2O
formate + L-kynurenine
Gallus gallus White leghorns
-
-
-
?
N-formyl-L-kynurenine + H2O
formate + L-kynurenine
-
step in tryptophan metabolism and biosynthesis of kynurenine-derived derivatives, e.g. kynurenic acid, quinolinic acid, nicotinamide, NAD+, and NADP+, pathway disruption causes neurotoxicity and immunotoxicity, overview
-
-
?
N-formyl-L-kynurenine + H2O
formate + L-kynurenine
-
-
-
?
N-formyl-L-kynurenine + H2O
formate + L-kynurenine
-
-
-
?
N-formyl-L-kynurenine + H2O
L-kynurenine + formate
-
involved in the pathway of tryptophan degradation
-
?
N-formyl-L-kynurenine + H2O
L-kynurenine + formate
-
formation of alcohol esters in the presence of alcohols
-
?
N-formyl-L-kynurenine + H2O
L-kynurenine + formate
-
unable to transfer a formyl group directly to tetrahydrofolic acid
-
?
N-formyl-L-kynurenine + H2O
L-kynurenine + formate
-
involved in the pathway of tryptophan degradation
-
?
N-formyl-L-kynurenine + H2O
L-kynurenine + formate
-
preferred substrate, involved in formation of antibiotics and NAD+
-
?
N-formyl-L-kynurenine + H2O
L-kynurenine + formate
-
formamidase II is an integral component of the actinomycin-synthesizing system
-
?
N-formyl-o-aminoacetophenone + H2O
formate + o-aminoacetophenone
-
-
-
?
N-formyl-o-aminoacetophenone + H2O
formate + o-aminoacetophenone
-
low activity
-
?
N-formyl-o-aminoacetophenone + H2O
formate + o-aminoacetophenone
-
22% of activity compared to N-formyl-L-kynurenine
-
?
N-formyl-o-aminoacetophenone + H2O
formate + o-aminoacetophenone
-
-
-
?
N-formyl-o-aminoacetophenone + H2O
formate + o-aminoacetophenone
-
60% of activity compared to N-formyl-L-kynurenine
-
?
N-formyl-o-aminoacetophenone + H2O
formate + o-aminoacetophenone
-
low activity for both formamidases I and II
-
?
N-formyl-o-aminoacetophenone + H2O
formate + o-aminoacetophenone
-
low activity for both formamidases I and II
-
?
N-formyl-o-aminoacetophenone + H2O
formate + o-aminoacetophenone
-
the only substrate
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
formation of alcohol esters in the presence of alcohols
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
involvement in anthranilate cycle
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
involvement in anthranilate cycle
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
involvement in anthranilate cycle
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
24% of activity compared to N-formyl-L-kynurenine
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
involvement in anthranilate cycle
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
10times slower hydrolysis than for N-formyl-L-kynurenine
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
low activity
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
13.5% activity compared to N-formyl-L-kynurenine
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
involvement in anthranilate cycle
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
involvement in anthranilate cycle
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
involvement in anthranilate cycle
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
involvement in anthranilate cycle
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
involvement in anthranilate cycle
-
?
N1,Nalpha-diformyl-L-kynurenine + H2O
formate + N-alpha-L-kynurenine
-
-
-
?
N1,Nalpha-diformyl-L-kynurenine + H2O
formate + N-alpha-L-kynurenine
-
-
-
?
N1,Nalpha-diformyl-L-kynurenine + H2O
formate + N-alpha-L-kynurenine
-
lower activity for formamidases I and II than for its natural substrate
-
?
N1,Nalpha-diformyl-L-kynurenine + H2O
formate + N-alpha-L-kynurenine
-
lower activity for formamidases I and II than for its natural substrate
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5-hydroxyformyl-DL-kynurenine + H2O
5-hydroxy-DL-kynurenine + formate
-
-
-
?
N-formyl-m-aminobenzoic acid + H2O
formate + m-aminobenzoic acid
-
very low activity
-
?
N-formyl-o-aminonitrobenzene + H2O
formate + o-nitroaniline
-
low activity
-
?
additional information
?
-
-
an enzyme other than the aryl formamidase additionally catalyzes the formation of L-kynurenine in kidney
-
-
?
N-formyl-L-kynurenine + H2O
formate + L-kynurenine
the enzyme forms part of the kynurenine pathway which metabolises tryptophan to anthranilate
-
-
?
N-formyl-L-kynurenine + H2O
formate + L-kynurenine
the enzyme forms part of the kynurenine pathway which metabolises tryptophan to anthranilate
-
-
?
N-formyl-L-kynurenine + H2O
formate + L-kynurenine
Gallus gallus White leghorns
-
-
-
?
N-formyl-L-kynurenine + H2O
formate + L-kynurenine
-
step in tryptophan metabolism and biosynthesis of kynurenine-derived derivatives, e.g. kynurenic acid, quinolinic acid, nicotinamide, NAD+, and NADP+, pathway disruption causes neurotoxicity and immunotoxicity, overview
-
-
?
N-formyl-L-kynurenine + H2O
formate + L-kynurenine
-
-
-
?
N-formyl-L-kynurenine + H2O
L-kynurenine + formate
-
involved in the pathway of tryptophan degradation
-
?
N-formyl-L-kynurenine + H2O
L-kynurenine + formate
-
formation of alcohol esters in the presence of alcohols
-
?
N-formyl-L-kynurenine + H2O
L-kynurenine + formate
-
unable to transfer a formyl group directly to tetrahydrofolic acid
-
?
N-formyl-L-kynurenine + H2O
L-kynurenine + formate
-
involved in the pathway of tryptophan degradation
-
?
N-formyl-L-kynurenine + H2O
L-kynurenine + formate
-
preferred substrate, involved in formation of antibiotics and NAD+
-
?
N-formyl-L-kynurenine + H2O
L-kynurenine + formate
-
formamidase II is an integral component of the actinomycin-synthesizing system
-
?
N-formyl-o-aminoacetophenone + H2O
formate + o-aminoacetophenone
-
-
-
?
N-formyl-o-aminoacetophenone + H2O
formate + o-aminoacetophenone
-
low activity
-
?
N-formyl-o-aminoacetophenone + H2O
formate + o-aminoacetophenone
-
22% of activity compared to N-formyl-L-kynurenine
-
?
N-formyl-o-aminoacetophenone + H2O
formate + o-aminoacetophenone
-
-
-
?
N-formyl-o-aminoacetophenone + H2O
formate + o-aminoacetophenone
-
60% of activity compared to N-formyl-L-kynurenine
-
?
N-formyl-o-aminoacetophenone + H2O
formate + o-aminoacetophenone
-
low activity for both formamidases I and II
-
?
N-formyl-o-aminoacetophenone + H2O
formate + o-aminoacetophenone
-
low activity for both formamidases I and II
-
?
N-formyl-o-aminoacetophenone + H2O
formate + o-aminoacetophenone
-
the only substrate
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
formation of alcohol esters in the presence of alcohols
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
involvement in anthranilate cycle
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
involvement in anthranilate cycle
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
involvement in anthranilate cycle
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
24% of activity compared to N-formyl-L-kynurenine
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
involvement in anthranilate cycle
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
10times slower hydrolysis than for N-formyl-L-kynurenine
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
low activity
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
13.5% activity compared to N-formyl-L-kynurenine
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
involvement in anthranilate cycle
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
involvement in anthranilate cycle
-
?
N-formylanthranilic acid + H2O
formate + anthranilic acid
-
involvement in anthranilate cycle
-
?