BRENDA - Enzyme Database show
show all sequences of 3.5.1.9

Formamidase in guinea pig liver II. Effect of aliphatic alcohols

Santti, R.S.; Hoppe-Seyler's Z. Physiol. Chem. 350, 1279-1285 (1969)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
butanol
activation e.g. between 0.75-2.5%, v/v, depending on substrate
Cavia porcellus
ethanol
activation e.g. between 2.5-12%, v/v, depending on substrate
Cavia porcellus
methanol
optimal activation e.g. between 5-15%, v/v, depending on substrate
Cavia porcellus
Propanol
activation e.g. between 1.5-5%, v/v, depending on substrate
Cavia porcellus
Inhibitors
Inhibitors
Commentary
Organism
Structure
acetone
inhibition up to 10%, v/v
Cavia porcellus
dimethyl sulfoxide
inhibition up to 10%, v/v
Cavia porcellus
dioxane
inhibition up to 10%, v/v
Cavia porcellus
N,N-Dimethylformamide
inhibition up to 10%, v/v
Cavia porcellus
Urea
25% inhibition at 2 M
Cavia porcellus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
N-formyl-L-kynurenine + H2O
Cavia porcellus
formation of alcohol esters in the presence of alcohols
L-kynurenine + formate
-
Cavia porcellus
?
N-formylanthranilic acid + H2O
Cavia porcellus
formation of alcohol esters in the presence of alcohols
formate + anthranilic acid
-
Cavia porcellus
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Cavia porcellus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Cavia porcellus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetanilide + H2O
formation of alcohol esters in the presence of alcohols
209259
Cavia porcellus
acetate + aniline
-
209259
Cavia porcellus
?
N-acetylanthranilic acid + H2O
formation of alcohol esters in the presence of alcohols
209259
Cavia porcellus
acetate + anthranilic acid
-
209259
Cavia porcellus
?
N-formyl-L-kynurenine + H2O
formation of alcohol esters in the presence of alcohols
209259
Cavia porcellus
L-kynurenine + formate
-
209259
Cavia porcellus
?
N-formylanthranilic acid + H2O
formation of alcohol esters in the presence of alcohols
209259
Cavia porcellus
formate + anthranilic acid
-
209259
Cavia porcellus
?
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
butanol
activation e.g. between 0.75-2.5%, v/v, depending on substrate
Cavia porcellus
ethanol
activation e.g. between 2.5-12%, v/v, depending on substrate
Cavia porcellus
methanol
optimal activation e.g. between 5-15%, v/v, depending on substrate
Cavia porcellus
Propanol
activation e.g. between 1.5-5%, v/v, depending on substrate
Cavia porcellus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
acetone
inhibition up to 10%, v/v
Cavia porcellus
dimethyl sulfoxide
inhibition up to 10%, v/v
Cavia porcellus
dioxane
inhibition up to 10%, v/v
Cavia porcellus
N,N-Dimethylformamide
inhibition up to 10%, v/v
Cavia porcellus
Urea
25% inhibition at 2 M
Cavia porcellus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
N-formyl-L-kynurenine + H2O
Cavia porcellus
formation of alcohol esters in the presence of alcohols
L-kynurenine + formate
-
Cavia porcellus
?
N-formylanthranilic acid + H2O
Cavia porcellus
formation of alcohol esters in the presence of alcohols
formate + anthranilic acid
-
Cavia porcellus
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Cavia porcellus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetanilide + H2O
formation of alcohol esters in the presence of alcohols
209259
Cavia porcellus
acetate + aniline
-
209259
Cavia porcellus
?
N-acetylanthranilic acid + H2O
formation of alcohol esters in the presence of alcohols
209259
Cavia porcellus
acetate + anthranilic acid
-
209259
Cavia porcellus
?
N-formyl-L-kynurenine + H2O
formation of alcohol esters in the presence of alcohols
209259
Cavia porcellus
L-kynurenine + formate
-
209259
Cavia porcellus
?
N-formylanthranilic acid + H2O
formation of alcohol esters in the presence of alcohols
209259
Cavia porcellus
formate + anthranilic acid
-
209259
Cavia porcellus
?
Other publictions for EC 3.5.1.9
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
743358
Gonzalez Esquivel
Kynurenine pathway metabolite ...
Equus caballus, Neurospora crassa, Neurospora crassa ATCC 24698, Oncorhynchus mykiss, Rattus norvegicus, Sus scrofa
Neuropharmacology
112
331-345
2017
5
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22
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22
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4
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6
-
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1
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-
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-
-
-
-
733300
Diaz-Saez
Structures of bacterial kynure ...
Bacillus anthracis, Burkholderia cenocepacia, Pseudomonas aeruginosa
Biochem. J.
462
581-589
2014
-
-
3
3
-
-
3
6
-
7
6
3
-
5
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3
3
-
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3
3
3
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-
3
3
-
-
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3
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3
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-
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3
-
6
-
7
6
3
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3
-
-
-
-
3
3
3
-
-
3
3
-
-
-
-
9
9
-
3
3
733741
Seifert
Structural requirements of org ...
Gallus gallus
Environ. Toxicol. Pharmacol.
35
200-206
2013
-
-
-
-
-
-
19
-
1
-
-
-
-
3
-
-
-
-
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2
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-
-
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19
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1
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2
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
733183
Zummo
Tryptophan catabolism via kynu ...
Streptomyces coelicolor, Streptomyces coelicolor M145
Appl. Microbiol. Biotechnol.
94
719-728
2012
-
-
1
-
-
-
-
1
-
1
-
2
-
6
-
-
1
-
-
-
1
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2
-
-
-
-
-
1
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-
-
-
-
-
-
1
-
-
-
-
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1
-
1
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2
-
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1
-
-
1
-
2
-
-
-
-
-
1
-
-
-
1
1
1
1
-
-
733287
Han
Biochemical identification and ...
Drosophila melanogaster
Biochem. J.
446
253-260
2012
-
-
1
1
-
-
3
1
-
-
-
1
-
2
-
-
1
1
-
-
-
-
2
-
1
-
-
1
1
-
-
-
1
1
-
-
-
1
-
1
-
-
-
3
1
1
-
-
-
1
-
-
-
1
-
-
-
-
2
-
1
-
-
1
1
-
-
1
-
4
4
-
1
1
711935
Ferguson
Shared and divergent expressio ...
Heliconius melpomene
Evol. Dev.
11
498-512
2009
-
-
-
-
-
-
-
-
-
-
-
1
-
6
-
-
-
-
-
-
-
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1
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-
-
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-
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-
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1
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-
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-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
685201
Wogulis
Identification of formyl kynur ...
Saccharomyces cerevisiae
Biochemistry
47
1608-1621
2008
-
-
1
-
-
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
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1
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1
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1
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1
1
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1
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1
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1
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1
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-
-
-
-
-
-
-
-
-
667794
Dobrovolsky
Effect of arylformamidase (kyn ...
Mus musculus
Biochim. Biophys. Acta
1724
163-172
2005
-
-
-
-
1
-
-
-
-
-
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2
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2
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2
7
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3
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1
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1
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2
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2
7
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
670776
Pabarcus
Cloning, expression, and catal ...
Mus musculus
Protein Expr. Purif.
44
39-44
2005
-
-
1
-
3
-
-
2
1
-
1
1
-
4
-
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1
1
-
1
1
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1
1
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1
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1
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3
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2
1
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1
1
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1
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1
1
-
1
1
-
-
-
-
1
-
-
-
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-
-
-
-
-
664978
Kurnasov
Aerobic tryptophan degradation ...
Bacillus cereus, Cupriavidus metallidurans, Cupriavidus metallidurans CH34, Pseudomonas aeruginosa
FEMS Microbiol. Lett.
227
219-227
2003
-
3
3
-
-
-
2
-
-
3
-
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15
-
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3
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3
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8
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3
3
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2
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3
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3
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3
-
8
-
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-
-
-
-
-
-
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-
-
-
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-
209242
Serrano
Inhibition studies on liver ar ...
Bos taurus, Oncorhynchus mykiss
Comp. Biochem. Physiol. B
99
281-285
1991
5
-
-
-
-
2
28
-
-
-
-
2
-
2
-
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2
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2
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6
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5
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-
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2
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28
6
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2
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2
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2
-
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-
-
-
-
-
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-
-
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209243
Serrano
Purification and characterizat ...
Bos taurus, Oncorhynchus mykiss
Comp. Biochem. Physiol. B
98
381-387
1991
-
-
-
-
-
-
-
3
-
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2
2
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5
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2
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4
2
2
4
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2
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2
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2
2
2
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3
-
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2
2
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2
-
4
2
2
4
-
2
-
2
-
2
2
2
-
-
-
-
-
-
-
209244
Katz
Arylformamidase from Streptomy ...
Streptomyces parvulus
Methods Enzymol.
142
225-234
1987
-
-
-
-
-
-
12
2
1
-
2
2
-
2
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1
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1
2
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3
-
2
-
1
-
2
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1
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-
-
-
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-
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12
1
2
1
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2
2
-
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-
1
-
1
2
-
3
-
2
-
1
-
2
-
-
-
-
-
-
-
-
-
209245
Brown
Purification and characterizat ...
Streptomyces parvulus
Can. J. Microbiol.
32
465-472
1986
-
-
-
-
-
-
-
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1
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2
2
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3
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1
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1
2
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3
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1
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2
2
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1
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1
2
-
3
-
-
-
-
-
-
-
-
-
-
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-
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-
209246
Brown
Evidence for a constitutive an ...
Streptomyces parvulus
Arch. Biochem. Biophys.
202
18-22
1980
-
-
-
-
-
-
-
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1
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1
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2
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1
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1
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1
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1
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-
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-
-
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-
-
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-
209247
Seifert
-
Inhibition and reactivation of ...
Gallus gallus
Pestic. Biochem. Physiol.
12
273-279
1979
-
-
-
-
-
-
28
4
-
-
1
2
-
1
-
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1
-
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1
-
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4
-
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1
-
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1
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1
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-
-
-
-
-
-
-
28
1
4
-
-
1
2
-
-
-
1
-
1
-
-
4
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
209248
Bode
-
Die Formamidase von Hansenula ...
Hansenula henricii
Biochem. Physiol. Pflanz.
174
26-38
1979
-
-
-
-
-
-
7
2
-
-
2
2
-
1
-
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1
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1
1
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2
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1
-
2
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7
-
2
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2
2
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1
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1
1
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2
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-
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1
-
2
-
-
-
-
-
-
-
-
-
209249
Bode
Vorkommen und Verteilung multi ...
Cyberlindnera fabianii, Cyberlindnera jadinii, Hansenula henricii, Meyerozyma guilliermondii, Rhodotorula mucilaginosa, Rhodotorula sphaerocarpa, Rhodotorula toruloides, Saccharomyces cerevisiae, Yarrowia lipolytica
Z. Allg. Mikrobiol.
19
221-222
1979
-
-
-
-
-
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18
18
-
9
-
-
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9
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18
-
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18
18
-
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9
-
-
18
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209250
Menge
Formamidase - Untersuchungen z ...
Rattus sp.
Hoppe-Seyler's Z. Physiol. Chem.
360
185-196
1979
-
-
-
-
-
-
6
2
-
-
1
2
-
1
-
-
1
-
-
1
1
-
3
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
6
1
2
-
-
1
2
-
-
-
1
-
1
1
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
209251
Moore
Biochemical and genetic charac ...
Drosophila melanogaster
Biochem. Genet.
16
619-634
1978
-
-
-
-
-
-
-
2
-
-
3
1
-
2
-
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1
-
-
-
-
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1
1
-
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-
-
-
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-
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-
-
-
-
-
-
-
2
-
-
3
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209252
Jacobson
A new substrate for formylkynu ...
Neurospora crassa
Arch. Biochem. Biophys.
186
84-88
1978
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
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-
-
-
1
-
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1
-
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1
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209253
Shinohara
New formamidase having substra ...
Cavia porcellus, no activity in Mus musculus, no activity in Rattus sp., Oryctolagus cuniculus, Sus scrofa
Biochim. Biophys. Acta
483
409-415
1977
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4
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3
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10
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1
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3
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209254
Moore
The characterization of multip ...
Bos taurus, Drosophila melanogaster, Drosophila virilis, Gallus gallus, Musca domestica, Mus musculus, Rana pipiens, Saccharomyces cerevisiae
Biochim. Biophys. Acta
397
468-477
1975
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11
4
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14
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4
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2
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2
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209255
Tsuda
Formamidase in rat brain ...
Rattus sp.
J. Neurochem.
22
679-683
1974
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2
2
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2
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2
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1
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209256
Bailey
Kynurenine formamidase. Purifi ...
Gallus gallus
J. Biol. Chem.
249
4439-4444
1974
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1
6
1
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2
1
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2
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1
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1
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209257
Arndt
Isolation and molecular proper ...
Rattus sp.
Hoppe-Seyler's Z. Physiol. Chem.
354
1583-1590
1973
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3
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1
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1
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1
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209258
Shinohara
The purification and propertie ...
Rattus sp.
Biochim. Biophys. Acta
198
324-331
1970
1
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9
2
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9
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1
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4
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1
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209259
Santti
Formamidase in guinea pig live ...
Cavia porcellus
Hoppe-Seyler's Z. Physiol. Chem.
350
1279-1285
1969
4
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209260
Santti
Kynurenine formamidase and tet ...
Cavia porcellus
Acta Chem. Scand.
22
3321-3323
1968
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2
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2
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209261
Jakoby
Kynurenine fromamidase from Ne ...
Neurospora crassa
J. Biol. Chem.
207
657-663
1954
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5
5
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5
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5
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1
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5
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1
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1
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209262
Mehler
The conversion of tryptophan t ...
Oryctolagus cuniculus
J. Biol. Chem.
187
431-438
1950
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2
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