Reference on EC 3.4.23.39 - plasmepsin II and Organism(s) Plasmodium falciparum and UniProt Accession Q8I6V3
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gluzman, I.Y.; Francis, S.E.; Oksman, A.; Smith, C.E.; Duffin, K.L.; Goldberg, D.E.
Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway
J. Clin. Invest.
93
1602-1608
1994
Plasmodium falciparum
Ersmark, K.; Feierberg, I.; Bjelic, S.; Hamelink, E.; Hackett, F.; Blackman, M.J.; Hulten, J.; Samuelsson, B.; Aqvist, J.; Hallberg, A.
Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity
J. Med. Chem.
47
110-122
2004
Plasmodium falciparum
Berry, C.
Plasmepsins as antimalarial targets
Curr. Opin. Drug Discov. Devel.
3
624-629
2000
Plasmodium falciparum
Dahlgren, A.; Kvarnstrom, I.; Vrang, L.; Hamelink, E.; Hallberg, A.; Rosenquist, A.; Samuelsson, B.
New inhibitors of the malaria aspartyl proteases plasmepsin I and II
Bioorg. Med. Chem.
11
3423-3437
2003
Plasmodium falciparum
Francis, S.E.; Banerjee, R.; Goldberg, D.E.
Biosynthesis and maturation of the malaria aspartic hemoglobinases plasmepsins I and II
J. Biol. Chem.
272
14961-14968
1997
Plasmodium falciparum
Moon, R.P.; Bur, D.; Loetscher, H.; D'Arcy, A.; Tyas, L.; Oefner, C.; Grueninger-Leitch, F.; Mona, D.; Rupp, K.; Dorn, A.; Matile, H.; Certa, U.; Berry, C.; Kay, J.; Ridley, R.G.
Studies on plasmepsins I and II from the malarial parasite Plasmodium falciparum and their exploitation as drug targets
Adv. Exp. Med. Biol.
436
397-406
1998
Plasmodium falciparum
Noteberg, D.; Hamelink, E.; Hulten, J.; Wahlgren, M.; Vrang, L.; Samuelsson, B.; Hallberg, A.
Design and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium falciparum-infected cultured human erythrocytes
J. Med. Chem.
46
734-746
2003
Plasmodium falciparum
Siripurkpong, P.; Yuvaniyama, J.; Wilairat, P.; Goldberg, D.E.
Active Site Contribution to Specificity of the Aspartic Proteases Plasmepsins I and II
J. Biol. Chem.
277
41009-41013
2002
Plasmodium falciparum
Tyas, L.; Gluzman, I.; Moon, R.P.; Rupp, K.; Westling, J.; Ridley, R.G.; Kay, J.; Goldberg, D.E.; Berry, C.
Naturally-occurring and recombinant forms of the aspartic proteinases plasmepsins I and II from the human malaria parasite Plasmodium falciparum
FEBS Lett.
454
210-214
1999
Plasmodium falciparum
Tyas, L.; Moon, R.P.; Loetscher, H.; Dunn, B.M.; Kay, J.; Ridley, R.G.; Berry, C.
Plasmepsins I and II from the malarial parasite Plasmodium falciparum
Adv. Exp. Med. Biol.
436
407-411
1998
Plasmodium falciparum
Moon, R.P.; Tyas, L.; Certa, U.; Rupp, K.; Bur, D.; Jacquet, C.; Matile, H.; Loetscher, H.; Grueninger-Leitch, F.; et al.
Expression and characterization of plasmepsin I from Plasmodium falciparum
Eur. J. Biochem.
244
552-560
1997
Plasmodium falciparum
Hill, J.; Tyas, L.; Phylip, L.H.; Kay, J.; Dunn, B.M.; Berry, C.
High level expression and characterisation of plasmepsin II, an aspartic proteinase from Plasmodium falciparum
FEBS Lett.
352
155-158
1994
Plasmodium falciparum
Dame, J.B.; Reddy, G.R.; Yowell, C.A.; Dunn, B.M.; Kay, J.; Berry, C.
Sequence, expression and modeled structure of an aspartic proteinase from the human malaria parasite Plasmidum falciparum
Mol. Biochem. Parasitol.
64
177-190
1994
Plasmodium falciparum, Plasmodium falciparum HB3
Bernstein, N.K.; Cherney, M.M.; Loetscher, H.; Ridley, R.G.; James, M.N.G.
Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from Plasmodium falciparum
Nat. Struct. Biol.
6
32-37
1999
Plasmodium falciparum
Asojo, O.A.; Afonina, E.; Gulnik, S.V.; Yu, B.; Erickson, J.W.; Randad, R.; Medjahed, D.; Silva, A.M.
Structures of Ser205 mutant plasmepsin II from Plasmodium falciparum at 1.8 A in complex with the inhibitors rs367 and rs370
Acta Crystallogr. Sect. D
58
2001-2008
2002
Plasmodium falciparum (P46925), Plasmodium falciparum
Asojo, O.A.; Gulnik, S.V.; Afonina, E.; Yu, B.; Ellman, J.A.; Haque, T.S.; Silva, A.M.
Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum
J. Mol. Biol.
327
173-181
2003
Plasmodium falciparum
Westling, J.; Cipullo, P.; Hung, S.H.; Saft, H.; Dame, J.B.; Dunn, B.M.
Active site specificity of plasmepsin II
Protein Sci.
8
2001-2009
1999
Plasmodium falciparum
Haque, T.S.; Skillman, A.G.; Lee, C.E.; Habashita, H.; Gluzman, I.Y.; Ewing, T.J.; Goldberg, D.E.; Kuntz, I.D.; Ellman, J.A.
Potent, low-molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II
J. Med. Chem.
42
1428-1440
1999
Plasmodium falciparum
Le Bonniec, S.; Deregnaucourt, C.; Redeker, V.; Banerjee, R.; Grellier, P.; Goldberg, D.E.; Schrevel, J.
Plasmepsin II, an acidic hemoglobinase from the Plasmodium falciparum food vacuole, is active at neutral pH on the host erythrocyte membrane skeleton
J. Biol. Chem.
274
14218-14223
1999
Plasmodium falciparum
Ersmark, K.; Nervall, M.; Gutierrez-de-Teran, H.; Hamelink, E.; Janka, L.K.; Clemente, J.C.; Dunn, B.M.; Gogoll, A.; Samuelsson, B.; Qvist, J.; Hallberg, A.
Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV
Bioorg. Med. Chem.
14
2197-2208
2006
Plasmodium falciparum
Romeo, S.; DellAgli, M.; Parapini, S.; Rizzi, L.; Galli, G.; Mondani, M.; Sparatore, A.; Taramelli, D.; Bosisio, E.
Plasmepsin II inhibition and antiplasmodial activity of Primaquine-Statine double-drugs
Bioorg. Med. Chem. Lett.
14
2931-2934
2004
Plasmodium falciparum
Corminboeuf, O.; Dunet, G.; Hafsi, M.; Grimont, J.; Grisostomi, C.; Meyer, S.; Binkert, C.; Bur, D.; Jones, A.; Prade, L.; Brun, R.; Boss, C.
Inhibitors of plasmepsin II-potential antimalarial agents
Bioorg. Med. Chem. Lett.
16
6194-6199
2006
Plasmodium falciparum
Boss, C.; Richard-Bildstein, S.; Furnari, R.; Bourgeois, J.; Corminboeuf, O.; Grisostomi, C.; Coppex, L.; Harris, L.; Prade, L.; Meyer, S.; Binkert, C.; Fischli, W.; Brun, R.; Weller, T.
Inhibitors of plasmepsin II - potential antimalarial agents
Chimia
58
634-639
2004
Plasmodium falciparum
-
Kim, Y.M.; Lee, M.H.; Piao, T.G.; Lee, J.W.; Kim, J.H.; Lee, S.; Choi, K.M.; Jiang, J.H.; Kim, T.U.; Park, H.
Prodomain processing of recombinant plasmepsin II and IV, the aspartic proteases of Plasmodium falciparum, is auto- and trans-catalytic
J. Biochem.
139
189-195
2006
Plasmodium falciparum
Prade, L.; Jones, A.F.; Boss, C.; Richard-Bildstein, S.; Meyer, S.; Binkert, C.; Bur, D.
X-ray structure of plasmepsin II complexed with a potent achiral inhibitor
J. Biol. Chem.
280
23837-23843
2005
Plasmodium falciparum
Istvan, E.S.; Goldberg, D.E.
Distal substrate interactions enhance plasmepsin activity
J. Biol. Chem.
280
6890-6896
2005
Plasmodium falciparum
Klemba, M.; Beatty, W.; Gluzman, I.; Goldberg, D.E.
Trafficking of plasmepsin II to the food vacuole of the malaria parasite Plasmodium falciparum
J. Cell Biol.
164
47-56
2004
Plasmodium falciparum
Johansson, P.O.; Chen, Y.; Belfrage, A.K.; Blackman, M.J.; Kvarnstroem, I.; Jansson, K.; Vrang, L.; Hamelink, E.; Hallberg, A.; Rosenquist, A.; Samuelsson, B.
Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs
J. Med. Chem.
47
3353-3366
2004
Plasmodium falciparum
Johansson, P.O.; Lindberg, J.; Blackman, M.J.; Kvarnstroem, I.; Vrang, L.; Hamelink, E.; Hallberg, A.; Rosenquist, A.; Samuelsson, B.
Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II
J. Med. Chem.
48
4400-4409
2005
Plasmodium falciparum
Kiso, A.; Hidaka, K.; Kimura, T.; Hayashi, Y.; Nezami, A.; Freire, E.; Kiso, Y.
Search for substrate-based inhibitors fitting the S2 space of malarial aspartic protease plasmepsin II
J. Pept. Sci.
10
641-647
2004
Plasmodium falciparum
Salas, E.; Ramirez, A.; Otero-Bilbao, A.; Vazquez, R.; Reyes, O.; Mendiola, J.; Duarte, C.A.; Otero-Gonzalez, A.; Gutierrez, O.A.; Chavez, M.A.
A heterogeneous enzymatic assay for quantification of plasmepsin II activity and the evaluation of its inhibitors
J. Pharm. Biomed. Anal.
34
833-840
2004
Plasmodium falciparum
Ersmark, K.; Samuelsson, B.; Hallberg, A.
Plasmepsins as potential targets for new antimalarial therapy
Med. Res. Rev.
26
626-666
2006
Plasmodium falciparum
Hof, F.; Schutz, A.; Fah, C.; Meyer, S.; Bur, D.; Liu, J.; Goldberg, D.E.; Diederich, F.
Starving the malaria parasite: inhibitors active against the aspartic proteases plasmepsins I, II, and IV
Angew. Chem.
45
2138-2141
2006
Plasmodium falciparum
Bjelic, S.; Nervall, M.; Gutierrez-de-Teran, H.; Ersmark, K.; Hallberg, A.; Aqvist, J.
Computational inhibitor design against malaria plasmepsins
Cell. Mol. Life Sci.
64
2285-2305
2007
Plasmodium falciparum
Boss, C.; Corminboeuf, O.; Grisostomi, C.; Meyer, S.; Jones, A.F.; Prade, L.; Binkert, C.; Fischli, W.; Weller, T.; Bur, D.
Achiral, cheap, and potent inhibitors of plasmepsins I, II, and IV
ChemMedChem
1
1341-1345
2006
Plasmodium falciparum
DellAgli, M.; Parapini, S.; Galli, G.; Vaiana, N.; Taramelli, D.; Sparatore, A.; Liu, P.; Dunn, B.M.; Bosisio, E.; Romeo, S.
High antiplasmodial activity of novel plasmepsins I and II inhibitors
J. Med. Chem.
49
7440-7449
2006
Plasmodium falciparum
Bonilla, J.A.; Bonilla, T.D.; Yowell, C.A.; Fujioka, H.; Dame, J.B.
Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function
Mol. Microbiol.
65
64-75
2007
Plasmodium falciparum
Luksch, T.; Chan, N.S.; Brass, S.; Sotriffer, C.A.; Klebe, G.; Diederich, W.E.
Computer-aided design and synthesis of nonpeptidic plasmepsin II and IV inhibitors
ChemMedChem
3
1323-1336
2008
Plasmodium falciparum (P46925), Plasmodium falciparum
Robbins, A.H.; Dunn, B.M.; Agbandje-McKenna, M.; McKenna, R.
Crystallographic evidence for noncoplanar catalytic aspartic acids in plasmepsin II resides in the Protein Data Bank
Acta Crystallogr. Sect. D
65
294-296
2009
Plasmodium falciparum
Hidaka, K.; Kimura, T.; Ruben, A.J.; Uemura, T.; Kamiya, M.; Kiso, A.; Okamoto, T.; Tsuchiya, Y.; Hayashi, Y.; Freire, E.; Kiso, Y.
Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin
Bioorg. Med. Chem.
16
10049-10060
2008
Plasmodium falciparum
Ramirez, A.R.; Guerra, Y.; Otero, A.; Garcia, B.; Berry, C.; Mendiola, J.; Hernandez-Zanui, A.; Chavez, M.
Generation of an affinity matrix useful in the purification of natural inhibitors of plasmepsin II, an antimalarial-drug target
Biotechnol. Appl. Biochem.
52
149-157
2009
Plasmodium falciparum
Valiente, P.A.; Batista, P.R.; Pupo, A.; Pons, T.; Valencia, A.; Pascutti, P.G.
Predicting functional residues in Plasmodium falciparum plasmepsins by combining sequence and structural analysis with molecular dynamics simulations
Proteins
73
440-457
2008
Plasmodium falciparum (P46925)
Friedman, R.; Caflisch, A.
Pepsinogen-like activation intermediate of plasmepsin II revealed by molecular dynamics analysis
Proteins
73
814-827
2008
Plasmodium falciparum
Moura, P.A.; Dame, J.B.; Fidock, D.A.
Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors
Antimicrob. Agents Chemother.
53
4968-4978
2009
Plasmodium falciparum
Degliesposti, G.; Kasam, V.; Da Costa, A.; Kang, H.K.; Kim, N.; Kim, D.W.; Breton, V.; Kim, D.; Rastelli, G.
Design and discovery of plasmepsin II inhibitors using an automated workflow on large-scale grids
ChemMedChem
4
1164-1173
2009
Plasmodium falciparum
Friedman, R.; Caflisch, A.
Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring
ChemMedChem
4
1317-1326
2009
Plasmodium falciparum
Luksch, T.; Blum, A.; Klee, N.; Diederich, W.E.; Sotriffer, C.A.; Klebe, G.
Pyrrolidine derivatives as plasmepsin inhibitors: binding mode analysis assisted by molecular dynamics simulations of a highly flexible protein
ChemMedChem
5
443-454
2010
Plasmodium falciparum (P46925), Plasmodium falciparum
Marcoux, J.; Thierry, E.; Vives, C.; Signor, L.; Fieschi, F.; Forest, E.
Investigating alternative acidic proteases for H/D exchange coupled to mass spectrometry: plasmepsin 2 but not plasmepsin 4 is active under quenching conditions
J. Am. Soc. Mass Spectrom.
21
76-79
2010
Plasmodium falciparum
Mohapatra, S.C.; Tiwari, H.K.; Singla, M.; Rathi, B.; Sharma, A.; Mahiya, K.; Kumar, M.; Sinha, S.; Chauhan, S.S.
Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum
J. Biol. Inorg. Chem.
15
373-385
2010
Plasmodium falciparum
Gupta, D.; Yedidi, R.S.; Varghese, S.; Kovari, L.C.; Woster, P.M.
Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents
J. Med. Chem.
53
4234-4247
2010
Plasmodium falciparum
Faeh, C.; Hardegger, L.A.; Baitsch, L.; Schweizer, W.B.; Meyer, S.; Bur, D.; Diederich, F.
New organofluorine building blocks: inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic alpha,alpha-difluoroketone hydrates
Org. Biomol. Chem.
7
3947-3957
2009
Plasmodium falciparum
Parr-Vasquez, C.L.; Yada, R.Y.
Functional chimera of porcine pepsin prosegment and Plasmodium falciparum plasmepsin II
Protein Eng. Des. Sel.
23
19-26
2010
Plasmodium falciparum
Xiao, H.; Dee, D.; Yada, R.Y.
The native conformation of plasmepsin II is kinetically trapped at neutral pH
Arch. Biochem. Biophys.
513
102-109
2011
Plasmodium falciparum
Saify, Z.S.; Azim, M.K.; Ahmad, W.; Nisa, M.; Goldberg, D.E.; Hussain, S.A.; Akhtar, S.; Akram, A.; Arayne, A.; Oksman, A.; Khan, I.A.
New benzimidazole derivatives as antiplasmodial agents and plasmepsin inhibitors: Synthesis and analysis of structure-activity relationships
Bioorg. Med. Chem. Lett.
22
1282-1286
2012
Plasmodium falciparum
Dali, B.; Keita, M.; Megnassan, E.; Frecer, V.; Miertus, S.
Insight into selectivity of peptidomimetic inhibitors with modified statine core for plasmepsin II of Plasmodium falciparum over human Cathepsin D
Chem. Biol. Drug Des.
79
411-430
2011
Plasmodium falciparum
Nerdy, N.
In silico docking roselle (Hibiscus sabdariffa L.) calyces flavonoids as antimalarial against plasmepsin 1 and plasmepsin 2
Asian J. Pharm. Clin. Res.
10.
183
2017
Plasmodium falciparum (P46925)
-
Mishra, V.; Rathore, I.; Arekar, A.; Sthanam, L.K.; Xiao, H.; Kiso, Y.; Sen, S.; Patankar, S.; Gustchina, A.; Hidaka, K.; Wlodawer, A.; Yada, R.Y.; Bhaumik, P.
Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights
FEBS J.
285
3077-3096
2018
Plasmodium falciparum
Loesbanluechai, D.; Kotanan, N.; de Cozar, C.; Kochakarn, T.; Ansbro, M.R.; Chotivanich, K.; White, N.J.; Wilairat, P.; Lee, M.C.S.; Gamo, F.J.; Sanz, L.M.; Chookajorn, T.; Kuempornsin, K.
Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine
Int. J. Parasitol. Drugs Drug Resist.
9
16-22
2019
Plasmodium falciparum (Q8I6V3), Plasmodium falciparum
Huizing, A.P.; Mondal, M.; Hirsch, A.K.
Fighting malaria structureguided discovery of nonpeptidomimetic plasmepsin inhibitors
J. Med. Chem.
58
5151-5163
2015
Plasmodium falciparum (P46925), Plasmodium falciparum
Rasina, D.; Otikovs, M.; Leitans, J.; Recacha, R.; Borysov, O.V.; Kanepe-Lapsa, I.; Domraceva, I.; Pantelejevs, T.; Tars, K.; Blackman, M.J.; Jaudzems, K.; Jirgensons, A.
Fragment-based discovery of 2-aminoquinazolin-4(3H)-ones as novel class nonpeptidomimetic inhibitors of the plasmepsins I, II, and IV
J. Med. Chem.
59
374-387
2016
Plasmodium falciparum (P46925)
Singh, A.K.; Rathore, S.; Tang, Y.; Goldfarb, N.E.; Dunn, B.M.; Rajendran, V.; Ghosh, P.C.; Singh, N.; Latha, N.; Singh, B.K.; Rawat, M.; Rathi, B.
Hydroxyethylamine based phthalimides as new class of plasmepsin hits design, synthesis and antimalarial evaluation
PLoS ONE
10
e0139347
2015
Plasmodium falciparum
