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Literature summary for 3.4.23.39 extracted from
- Fighting malaria structureguided discovery of nonpeptidomimetic plasmepsin inhibitors (2015), J. Med. Chem., 58, 5151-5163 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (1R,2R,3R,4S)-3-[(4-butylphenyl)sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum |  |
| (1R,2R,3R,4S)-3-[(4-heptylphenyl)sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S)-3-[(4-hexylphenyl)sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S)-3-[[4-(2-cyclobutylethyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S)-3-[[4-(2-cyclopentylethyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S)-3-[[4-(3-cyclohexylpropyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S)-3-[[4-(3-cyclopentylpropyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S)-3-[[4-(3-ethoxypropyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S)-3-[[4-(4,4-dimethylpentyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S)-3-[[4-(4-fluorobutyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S)-3-[[4-(4-methoxybutyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S)-3-[[4-(6-fluorohexyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S)-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S)-N-(naphthalen-2-ylmethyl)-3-[[4-(2-propoxyethyl)phenyl]sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S)-N-(naphthalen-2-ylmethyl)-3-[[4-(pentyloxy)phenyl]sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S,5R)-5-[(cyclobutylamino)methyl]-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S,5R)-5-[(cyclopentylamino)methyl]-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S,6R)-6-[(cyclobutylamino)methyl]-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3R,4S,6R)-6-[(cyclopentylamino)methyl]-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine | - |
Plasmodium falciparum | |
| (1R,2R,3S,4S)-2,3-bis(naphthalen-2-ylmethoxy)-7-azabicyclo[2.2.1]heptane | - |
Plasmodium falciparum | |
| (1R,4S)-6-[2-(1,3-benzothiazol-2-ylsulfanyl)ethoxy]-7-(naphthalen-1-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene | - |
Plasmodium falciparum | |
| (1R,4S)-6-[2-(1,3-benzothiazol-2-ylsulfanyl)ethoxy]-7-(naphthalen-2-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene | - |
Plasmodium falciparum | |
| (1R,4S)-6-[2-(1,3-benzothiazol-2-ylsulfanyl)ethoxy]-7-[2-(naphthalen-1-yl)ethoxy]-1,2,3,4-tetrahydro-1,4-epiminonaphthalene | - |
Plasmodium falciparum | |
| (1R,4S)-6-[2-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]ethoxy]-7-(naphthalen-1-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene | - |
Plasmodium falciparum | |
| (1R,4S)-6-[2-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]ethoxy]-7-(naphthalen-2-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene | - |
Plasmodium falciparum | |
| (1R,4S)-6-[2-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]ethoxy]-7-[2-(naphthalen-1-yl)ethoxy]-1,2,3,4-tetrahydro-1,4-epiminonaphthalene | - |
Plasmodium falciparum | |
| (1R,4S)-6-[3-(1,3-benzothiazol-2-ylsulfanyl)propyl]-7-(naphthalen-1-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene | - |
Plasmodium falciparum | |
| (1R,4S)-6-[3-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]propyl]-7-(naphthalen-1-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene | - |
Plasmodium falciparum | |
| (1S)-3,3-difluoro-4,4-dihydroxy-N-(naphthalen-2-ylmethyl)-N-(4-pentylphenyl)cyclohexanecarboxamide | - |
Plasmodium falciparum | |
| (1S,2S,3R,4R)-2-([4-[3-(1,3-benzodioxol-5-yl)propyl]benzyl]oxy)-3-(naphthalen-2-ylmethoxy)-7-azabicyclo[2.2.1]heptane | - |
Plasmodium falciparum | |
| (1S,2S,3R,4R)-2-[(4-bromobenzyl)oxy]-3-(naphthalen-2-ylmethoxy)-7-azabicyclo[2.2.1]heptane | - |
Plasmodium falciparum | |
| (1Z)-(3,4-dimethoxyphenyl)-N'-[[(3,4,5-trichlorophenoxy)acetyl]oxy]ethanimidamide | - |
Plasmodium falciparum | |
| (3S,4S)-pyrrolidine-3,4-diyl bis(naphthalen-1-ylacetate) | - |
Plasmodium falciparum | |
| (3S,4S)-pyrrolidine-3,4-diyl dibenzoate | - |
Plasmodium falciparum | |
| (5-[[(4-bromobenzoyl)oxy]methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl)methyl 4-aminobenzoate | - |
Plasmodium falciparum | |
| 1,2-diphenylhydrazine | - |
Plasmodium falciparum | |
| 1-(benzylamino)-3-(3,6-dichloro-9H-carbazol-9-yl)propan-2-ol | - |
Plasmodium falciparum | |
| 1-[3-chloro-6-(trifluoromethyl)phenanthren-9-yl]-3-(dibutylamino)propan-1-ol | - |
Plasmodium falciparum | |
| 1-[6-chloro-3-(3,4-dichlorophenyl)naphthalen-1-yl]-2-(dibutylamino)ethanol | - |
Plasmodium falciparum | |
| 2,2-diphenylacetohydrazide | - |
Plasmodium falciparum | |
| 2,3,4-trifluoro-N-([[1-(3-methylbutyl)piperidin-4-yl](4-pentylbenzoyl)amino]methyl)benzamide | - |
Plasmodium falciparum | |
| 2-(dihexylamino)-1-(1,2,3,4-tetrahydrophenanthren-9-yl)ethanol | - |
Plasmodium falciparum | |
| 2-([2-[4-([[(1S,2S,3R,4R)-3-(naphthalen-2-ylmethoxy)-7-azabicyclo[2.2.1]hept-2-yl]oxy]methyl)phenoxy]ethyl]sulfanyl)-1,3-benzothiazole | - |
Plasmodium falciparum | |
| 2-methoxybenzohydrazide | - |
Plasmodium falciparum | |
| 2-nitrobenzohydrazide | - |
Plasmodium falciparum | |
| 2-[(Z)-1-(4-chlorophenyl)-2-[3-(pyridin-2-yl)isoquinolin-1-yl]ethenyl]hydrazine-1-carboximidothioic acid | - |
Plasmodium falciparum | |
| 2-[bis(4-methylpentyl)amino]-1-(1,2,3,4-tetrahydrophenanthren-9-yl)ethanol | - |
Plasmodium falciparum | |
| 3-amino-N-[(4S,6S,7S)-7-[[(2,6-dimethylphenoxy)acetyl]amino]-6-hydroxy-2-methyl-8-phenyloctan-4-yl]benzamide | - |
Plasmodium falciparum | |
| 4,4'-(hydrazine-1,2-diyl)dipyridine | - |
Plasmodium falciparum | |
| 4-amino-N'-(benzyloxy)-N-(2-methylphenyl)-1,2,5-oxadiazole-3-carboximidamide | - |
Plasmodium falciparum | |
| 4-amino-N'-[(2,4-dichlorophenyl)methoxy]-N-(2-methylphenyl)-1,2,5-oxadiazole-3-carboximidamide | - |
Plasmodium falciparum | |
| 4-amino-N-[(4S,6S,7S)-7-[[(2,6-dimethylphenoxy)acetyl]amino]-6-hydroxy-2-methyl-8-phenyloctan-4-yl]benzamide | - |
Plasmodium falciparum | |
| 4-methyl-N-[2-[2-(naphthalen-2-yl)hydrazinyl]phenyl]benzene-1-sulfonamide | - |
Plasmodium falciparum | |
| 5-[4-([(1S,2R,3R,4R)-3-[(naphthalen-2-ylmethyl)amino]-7-azabicyclo[2.2.1]hept-2-yl]sulfonyl)phenyl]pentan-1-ol | - |
Plasmodium falciparum | |
| 6-[4-([(1S,2R,3R,4R)-3-[(naphthalen-2-ylmethyl)amino]-7-azabicyclo[2.2.1]hept-2-yl]sulfonyl)phenyl]hex-5-yn-1-ol | - |
Plasmodium falciparum | |
| 6-[4-([(1S,2R,3R,4R)-3-[(naphthalen-2-ylmethyl)amino]-7-azabicyclo[2.2.1]hept-2-yl]sulfonyl)phenyl]hexan-1-ol | - |
Plasmodium falciparum | |
| butanehydrazide | - |
Plasmodium falciparum | |
| methyl [4'-([[1-(1H-imidazol-2-ylmethyl)piperidin-4-yl](4-pentylbenzoyl)amino]methyl)biphenyl-4-yl]acetate | - |
Plasmodium falciparum | |
| N',N''-[1,10-phenanthroline-2,9-diyldi(E)methylylidene]bis[N-(2-methylphenyl)pyridine-2-carbohydrazonamide] | - |
Plasmodium falciparum | |
| N'-(3,4-dimethylacridin-9-yl)-2-hydroxybenzohydrazide | - |
Plasmodium falciparum | |
| N'-(3,4-dimethylacridin-9-yl)-3-methylbenzohydrazide | - |
Plasmodium falciparum | |
| N'-(4-chlorophenyl)-N'-(2-[[(3-chlorophenyl)carbamoyl]amino]phenyl)urea | - |
Plasmodium falciparum | |
| N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(N-benzyl-2-phenylacetamide) | - |
Plasmodium falciparum | |
| N-(3,4-dichlorophenyl)-2-[(4,6-dimethylpyrimidin-2-yl)amino]-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole-1-carboxamide | - |
Plasmodium falciparum | |
| N-(cyclopentylcarbamothioyl)-4-ethoxy-3-nitrobenzamide | - |
Plasmodium falciparum | |
| N-([5-[3,5-bis(trifluoromethyl)phenyl]furan-2-yl]methyl)-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide | - |
Plasmodium falciparum | |
| N-([[1-(3-methylbutyl)piperidin-4-yl](4-pentylbenzoyl)amino]methyl)-1-benzothiophene-2-carboxamide | - |
Plasmodium falciparum | |
| N-([[1-(3-methylbutyl)piperidin-4-yl](4-pentylbenzoyl)amino]methyl)pyridine-3-carboxamide | - |
Plasmodium falciparum | |
| N-benzyl-2-bromo-N-[[4-([[3-(2,4-dichlorophenyl)propyl](3-phenylpropyl)amino]methyl)pyrrolidin-3-yl]methyl]-4,5-dimethoxybenzamide | - |
Plasmodium falciparum | |
| N-benzyl-2-bromo-N-[[4-([[3-(2,4-dichlorophenyl)propyl][2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]amino]methyl)pyrrolidin-3-yl]methyl]-4,5-dimethoxybenzamide | - |
Plasmodium falciparum | |
| N-[(3-ethyl-1,2-oxazol-5-yl)methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide | - |
Plasmodium falciparum | |
| N-[(E)-[(2,4-dimethylphenyl)amino][(4-oxo-1,4,5,6,7,8-hexahydroquinolin-2-yl)amino]methylidene]benzamide | - |
Plasmodium falciparum | |
| N-[1-(3-methylbutyl)piperidin-4-yl]-5-pentyl-N-[[4'-(piperidin-1-ylcarbonyl)biphenyl-4-yl]methyl]pyridine-2-carboxamide | - |
Plasmodium falciparum | |
| N-[1-(3-methylbutyl)piperidin-4-yl]-N-(2-[4-[methyl(2-methylquinolin-4-yl)amino]phenyl]ethyl)-4-pentylbenzamide | - |
Plasmodium falciparum | |
| N-[1-(3-methylbutyl)piperidin-4-yl]-N-[[methyl(pyridin-3-yl)amino]methyl]-4-pentylbenzamide | - |
Plasmodium falciparum | |
| N-[[(1S)-3,3-difluoro-4,4-dihydroxycyclohexyl]methyl]-N-(4-pentylphenyl)naphthalene-2-carboxamide | - |
Plasmodium falciparum | |
| N-[[5-(2,5-dichlorophenyl)furan-2-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide | - |
Plasmodium falciparum | |
| N-[[5-(3,4-dichlorophenyl)furan-2-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide | - |
Plasmodium falciparum | |
| N-[[5-(3,4-dimethoxybenzyl)-1,2,4-oxadiazol-3-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide | - |
Plasmodium falciparum | |
| N-[[5-(4-chlorophenyl)-1,2-oxazol-3-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide | - |
Plasmodium falciparum | |
| N2-(3-bromophenyl)-N-[4-[(phenylsulfanyl)methyl]phenyl]-N2-(phenylsulfonyl)glycinamide | - |
Plasmodium falciparum | |
| pepstatin A | - |
Plasmodium falciparum | |
| [5-[(benzoyloxy)methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl]methyl 4-aminobenzoate | - |
Plasmodium falciparum | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium falciparum | P46925 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PLm II | - |
Plasmodium falciparum |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000005 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N'-(3,4-dimethylacridin-9-yl)-3-methylbenzohydrazide | |
| 0.000004 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N'-(3,4-dimethylacridin-9-yl)-2-hydroxybenzohydrazide | |
| 0.0000043 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1Z)-(3,4-dimethoxyphenyl)-N'-[[(3,4,5-trichlorophenoxy)acetyl]oxy]ethanimidamide | |
| 0.0000044 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-(cyclopentylcarbamothioyl)-4-ethoxy-3-nitrobenzamide | |
| 0.0000055 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 4-amino-N'-[(2,4-dichlorophenyl)methoxy]-N-(2-methylphenyl)-1,2,5-oxadiazole-3-carboximidamide | |
| 0.0000064 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 4-amino-N'-(benzyloxy)-N-(2-methylphenyl)-1,2,5-oxadiazole-3-carboximidamide | |
| 0.0000076 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N'-(4-chlorophenyl)-N'-(2-[[(3-chlorophenyl)carbamoyl]amino]phenyl)urea | |
| 0.0000088 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-[(E)-[(2,4-dimethylphenyl)amino][(4-oxo-1,4,5,6,7,8-hexahydroquinolin-2-yl)amino]methylidene]benzamide | |
| 0.0000095 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-(3,4-dichlorophenyl)-2-[(4,6-dimethylpyrimidin-2-yl)amino]-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole-1-carboxamide | |
| 0.000018 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-[(3-ethyl-1,2-oxazol-5-yl)methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide | |
| 0.000019 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-([5-[3,5-bis(trifluoromethyl)phenyl]furan-2-yl]methyl)-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide | |
| 0.00003 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S)-3-[[4-(2-cyclopentylethyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.000031 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-([[1-(3-methylbutyl)piperidin-4-yl](4-pentylbenzoyl)amino]methyl)-1-benzothiophene-2-carboxamide | |
| 0.000032 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-[[5-(3,4-dimethoxybenzyl)-1,2,4-oxadiazol-3-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide | |
| 0.000034 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | methyl [4'-([[1-(1H-imidazol-2-ylmethyl)piperidin-4-yl](4-pentylbenzoyl)amino]methyl)biphenyl-4-yl]acetate | |
| 0.000039 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 2,3,4-trifluoro-N-([[1-(3-methylbutyl)piperidin-4-yl](4-pentylbenzoyl)amino]methyl)benzamide | |
| 0.000047 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-[[5-(3,4-dichlorophenyl)furan-2-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide | |
| 0.00005 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S)-3-[(4-heptylphenyl)sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.00005 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S)-3-[[4-(4,4-dimethylpentyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.000054 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-[1-(3-methylbutyl)piperidin-4-yl]-5-pentyl-N-[[4'-(piperidin-1-ylcarbonyl)biphenyl-4-yl]methyl]pyridine-2-carboxamide | |
| 0.000067 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-[[5-(2,5-dichlorophenyl)furan-2-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide | |
| 0.000089 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S,5R)-5-[(cyclobutylamino)methyl]-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.0001 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S,5R)-5-[(cyclopentylamino)methyl]-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.000113 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-[1-(3-methylbutyl)piperidin-4-yl]-N-[[methyl(pyridin-3-yl)amino]methyl]-4-pentylbenzamide | |
| 0.00013 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S)-3-[(4-hexylphenyl)sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.000145 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-[1-(3-methylbutyl)piperidin-4-yl]-N-(2-[4-[methyl(2-methylquinolin-4-yl)amino]phenyl]ethyl)-4-pentylbenzamide | |
| 0.000146 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-([[1-(3-methylbutyl)piperidin-4-yl](4-pentylbenzoyl)amino]methyl)pyridine-3-carboxamide | |
| 0.00015 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S)-N-(naphthalen-2-ylmethyl)-3-[[4-(pentyloxy)phenyl]sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.00017 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S)-3-[[4-(2-cyclobutylethyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.00019 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S)-3-[[4-(3-cyclopentylpropyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.000236 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-[[5-(4-chlorophenyl)-1,2-oxazol-3-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide | |
| 0.000284 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S,6R)-6-[(cyclobutylamino)methyl]-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.000289 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S,6R)-6-[(cyclopentylamino)methyl]-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.00035 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S)-3-[[4-(6-fluorohexyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.00038 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S)-3-[[4-(3-cyclohexylpropyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.0005 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (5-[[(4-bromobenzoyl)oxy]methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl)methyl 4-aminobenzoate | |
| 0.00055 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(N-benzyl-2-phenylacetamide) | |
| 0.00064 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-benzyl-2-bromo-N-[[4-([[3-(2,4-dichlorophenyl)propyl][2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]amino]methyl)pyrrolidin-3-yl]methyl]-4,5-dimethoxybenzamide | |
| 0.00068 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S)-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.00079 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 6-[4-([(1S,2R,3R,4R)-3-[(naphthalen-2-ylmethyl)amino]-7-azabicyclo[2.2.1]hept-2-yl]sulfonyl)phenyl]hexan-1-ol | |
| 0.00081 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-benzyl-2-bromo-N-[[4-([[3-(2,4-dichlorophenyl)propyl](3-phenylpropyl)amino]methyl)pyrrolidin-3-yl]methyl]-4,5-dimethoxybenzamide | |
| 0.0009 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S)-N-(naphthalen-2-ylmethyl)-3-[[4-(2-propoxyethyl)phenyl]sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.001 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 2-nitrobenzohydrazide | |
| 0.00105 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 1,2-diphenylhydrazine | |
| 0.00125 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | butanehydrazide | |
| 0.0013 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (3S,4S)-pyrrolidine-3,4-diyl bis(naphthalen-1-ylacetate) | |
| 0.00145 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 4,4'-(hydrazine-1,2-diyl)dipyridine | |
| 0.0016 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 2,2-diphenylacetohydrazide | |
| 0.00165 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 2-methoxybenzohydrazide | |
| 0.002 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,4S)-6-[3-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]propyl]-7-(naphthalen-1-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene | |
| 0.002 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 1-[3-chloro-6-(trifluoromethyl)phenanthren-9-yl]-3-(dibutylamino)propan-1-ol | |
| 0.00221 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S)-3-[[4-(4-fluorobutyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.003 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,4S)-6-[2-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]ethoxy]-7-[2-(naphthalen-1-yl)ethoxy]-1,2,3,4-tetrahydro-1,4-epiminonaphthalene | |
| 0.004 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,4S)-6-[2-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]ethoxy]-7-(naphthalen-2-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene | |
| 0.004 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,4S)-6-[3-(1,3-benzothiazol-2-ylsulfanyl)propyl]-7-(naphthalen-1-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene | |
| 0.00419 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3R,4S)-3-[(4-butylphenyl)sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine | |
| 0.00461 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 5-[4-([(1S,2R,3R,4R)-3-[(naphthalen-2-ylmethyl)amino]-7-azabicyclo[2.2.1]hept-2-yl]sulfonyl)phenyl]pentan-1-ol | |
| 0.00462 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N',N''-[1,10-phenanthroline-2,9-diyldi(E)methylylidene]bis[N-(2-methylphenyl)pyridine-2-carbohydrazonamide] | |
| 0.005 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,4S)-6-[2-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]ethoxy]-7-(naphthalen-1-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene | |
| 0.005 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 1-[6-chloro-3-(3,4-dichlorophenyl)naphthalen-1-yl]-2-(dibutylamino)ethanol | |
| 0.005 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 2-(dihexylamino)-1-(1,2,3,4-tetrahydrophenanthren-9-yl)ethanol | |
| 0.005 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 2-[bis(4-methylpentyl)amino]-1-(1,2,3,4-tetrahydrophenanthren-9-yl)ethanol | |
| 0.006 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | [5-[(benzoyloxy)methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl]methyl 4-aminobenzoate | |
| 0.00645 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 2-[(Z)-1-(4-chlorophenyl)-2-[3-(pyridin-2-yl)isoquinolin-1-yl]ethenyl]hydrazine-1-carboximidothioic acid | |
| 0.007 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 4-methyl-N-[2-[2-(naphthalen-2-yl)hydrazinyl]phenyl]benzene-1-sulfonamide | |
| 0.007 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N-[[(1S)-3,3-difluoro-4,4-dihydroxycyclohexyl]methyl]-N-(4-pentylphenyl)naphthalene-2-carboxamide | |
| 0.00899 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | N2-(3-bromophenyl)-N-[4-[(phenylsulfanyl)methyl]phenyl]-N2-(phenylsulfonyl)glycinamide | |
| 0.009 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 2-([2-[4-([[(1S,2S,3R,4R)-3-(naphthalen-2-ylmethoxy)-7-azabicyclo[2.2.1]hept-2-yl]oxy]methyl)phenoxy]ethyl]sulfanyl)-1,3-benzothiazole | |
| 0.00947 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | 1-(benzylamino)-3-(3,6-dichloro-9H-carbazol-9-yl)propan-2-ol | |
| 0.01 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,4S)-6-[2-(1,3-benzothiazol-2-ylsulfanyl)ethoxy]-7-(naphthalen-2-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene | |
| 0.01 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1S)-3,3-difluoro-4,4-dihydroxy-N-(naphthalen-2-ylmethyl)-N-(4-pentylphenyl)cyclohexanecarboxamide | |
| 0.013 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,4S)-6-[2-(1,3-benzothiazol-2-ylsulfanyl)ethoxy]-7-[2-(naphthalen-1-yl)ethoxy]-1,2,3,4-tetrahydro-1,4-epiminonaphthalene | |
| 0.014 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,4S)-6-[2-(1,3-benzothiazol-2-ylsulfanyl)ethoxy]-7-(naphthalen-1-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene | |
| 0.0244 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (3S,4S)-pyrrolidine-3,4-diyl dibenzoate | |
| 0.07 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1S,2S,3R,4R)-2-([4-[3-(1,3-benzodioxol-5-yl)propyl]benzyl]oxy)-3-(naphthalen-2-ylmethoxy)-7-azabicyclo[2.2.1]heptane | |
| 0.7 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1R,2R,3S,4S)-2,3-bis(naphthalen-2-ylmethoxy)-7-azabicyclo[2.2.1]heptane | |
| 1 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | (1S,2S,3R,4R)-2-[(4-bromobenzyl)oxy]-3-(naphthalen-2-ylmethoxy)-7-azabicyclo[2.2.1]heptane | |
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