Reference on EC 3.4.19.12 - ubiquitinyl hydrolase 1 and Organism(s) Mus musculus and UniProt Accession Q9R0P9
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Osaka, H.; Wang, Y.L.; Takada, K.; Takizawa, S.; Setsuie, R.; Li, H.; Sato, Y.; Nishikawa, K.; Sun, Y.J.; Sakurai, M.; Harada, T.; Hara, Y.; Kimura, I.; Chiba, S.; Namikawa, K.; Kiyama, H.; Noda, M.; Aoki, S.; Wada, K.
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron
Hum. Mol. Genet.
12
1945-1958
2003
Mus musculus, Mus musculus (Q9R0P9)
Harada, T.; Harada, C.; Wang, Y.L.; Osaka, H.; Amanai, K.; Tanaka, K.; Takizawa, S.; Setsuie, R.; Sakurai, M.; Sato, Y.; Noda, M.; Wada, K.
Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo
Am. J. Pathol.
164
59-64
2004
Mus musculus
Kwon, J.; Wang, Y.L.; Setsuie, R.; Sekiguchi, S.; Sato, Y.; Sakurai, M.; Noda, M.; Aoki, S.; Yoshikawa, Y.; Wada, K.
Two closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testis
Am. J. Pathol.
165
1367-1374
2004
Mus musculus, Mus musculus (Q9R0P9)
Kwon, J.; Wang, Y.L.; Setsuie, R.; Sekiguchi, S.; Sakurai, M.; Sato, Y.; Lee, W.W.; Ishii, Y.; Kyuwa, S.; Noda, M.; Wada, K.; Yoshikawa, Y.
Developmental regulation of ubiquitin C-terminal hydrolase isozyme expression during spermatogenesis in mice
Biol. Reprod.
71
515-521
2004
Mus musculus, Mus musculus (P15347), Mus musculus (Q9R0P9)
Kwon, J.; Mochida, K.; Wang, Y.L.; Sekiguchi, S.; Sankai, T.; Aoki, S.; Ogura, A.; Yoshikawa, Y.; Wada, K.
Ubiquitin C-terminal hydrolase L-1 is essential for the early apoptotic wave of germinal cells and for sperm quality control during spermatogenesis
Biol. Reprod.
73
29-35
2005
Mus musculus, Mus musculus (Q9R0P9)
Kwon, J.; Sekiguchi, S.; Wang, Y.L.; Setsuie, R.; Yoshikawa, Y.; Wada, K.
The region-specific functions of two ubiquitin C-terminal hydrolase isozymes along the epididymis
Exp. Anim.
55
35-43
2006
Mus musculus, Mus musculus (Q9R0P9)
Wood, M.A.; Kaplan, M.P.; Brensinger, C.M.; Guo, W.; Abel, T.
Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory
Hippocampus
15
610-621
2005
Mus musculus, Mus musculus (Q9JKB1)
Sakurai, M.; Ayukawa, K.; Setsuie, R.; Nishikawa, K.; Hara, Y.; Ohashi, H.; Nishimoto, M.; Abe, T.; Kudo, Y.; Sekiguchi, M.; Sato, Y.; Aoki, S.; Noda, M.; Wada, K.
Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation
J. Cell Sci.
119
162-171
2006
Homo sapiens, Mus musculus, Mus musculus (Q9R0P9)
Dong, X.; Yagita, K.; Zhang, J.; Okamura, H.
Expression of ubiquitin-related enzymes in the suprachiasmatic nucleus with special reference to ubiquitin carboxy-terminal hydrolase UchL1
Biomed. Res.
26
43-49
2005
Mus musculus (Q9R0P9)
Gong, B.; Cao, Z.; Zheng, P.; Vitolo, O.V.; Liu, S.; Staniszewski, A.; Moolman, D.; Zhang, H.; Shelanski, M.; Arancio, O.
Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory
Cell
126
775-788
2006
Mus musculus, Mus musculus (Q9R0P9)
Sekiguchi, S.; Yoshikawa, Y.; Tanaka, S.; Kwon, J.; Ishii, Y.; Kyuwa, S.; Wada, K.; Nakamura, S.; Takahashi, K.
Immunohistochemical analysis of protein gene product 9.5, a ubiquitin carboxyl-terminal hydrolase, during placental and embryonic development in the mouse
Exp. Anim.
52
365-369
2003
Mus musculus (Q9R0P9), Mus musculus
Poon, H.F.; Hensley, K.; Thongboonkerd, V.; Merchant, M.L.; Lynn, B.C.; Pierce, W.M.; Klein, J.B.; Calabrese, V.; Butterfield, D.A.
Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis
Free Radic. Biol. Med.
39
453-462
2005
Mus musculus (Q9R0P9), Mus musculus
Castegna, A.; Thongboonkerd, V.; Klein, J.; Lynn, B.C.; Wang, Y.L.; Osaka, H.; Wada, K.; Butterfield, D.A.
Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins
J. Neurochem.
88
1540-1546
2004
Mus musculus (Q9R0P9), Mus musculus
Wang, Y.L.; Liu, W.; Sun, Y.J.; Kwon, J.; Setsuie, R.; Osaka, H.; Noda, M.; Aoki, S.; Yoshikawa, Y.; Wada, K.
Overexpression of ubiquitin carboxyl-terminal hydrolase L1 arrests spermatogenesis in transgenic mice
Mol. Reprod. Dev.
73
40-49
2006
Mus musculus (Q9R0P9), Mus musculus
Sano, Y.; Furuta, A.; Setsuie, R.; Kikuchi, H.; Wang, Y.L.; Sakurai, M.; Kwon, J.; Noda, M.; Wada, K.
Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice
Am. J. Pathol.
169
132-141
2006
Mus musculus
Sekiguchi, S.; Kwon, J.; Yoshida, E.; Hamasaki, H.; Ichinose, S.; Hideshima, M.; Kuraoka, M.; Takahashi, A.; Ishii, Y.; Kyuwa, S.; Wada, K.; Yoshikawa, Y.
Localization of ubiquitin C-terminal hydrolase L1 in mouse ova and its function in the plasma membrane to block polyspermy
Am. J. Pathol.
169
1722-1729
2006
Mus musculus
Mermerian, A.H.; Case, A.; Stein, R.L.; Cuny, G.D.
Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors
Bioorg. Med. Chem. Lett.
17
3729-3732
2007
Mus musculus
Lansbury, P.T.
Improving synaptic function in a mouse model of AD
Cell
126
655-657
2006
Aplysia sp., Homo sapiens, Mus musculus
Bifsha, P.; Landry, K.; Ashmarina, L.; Durand, S.; Seyrantepe, V.; Trudel, S.; Quiniou, C.; Chemtob, S.; Xu, Y.; Gravel, R.A.; Sladek, R.; Pshezhetsky, A.V.
Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway
Cell Death Differ.
14
511-523
2007
Mus musculus, Homo sapiens (P09936), Homo sapiens
Sakurai, M.; Sekiguchi, M.; Zushida, K.; Yamada, K.; Nagamine, S.; Kabuta, T.; Wada, K.
Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene
Eur. J. Neurosci.
27
691-701
2008
Mus musculus, Mus musculus C57/BL6J
Mauri, P.L.; Riva, M.; Ambu, D.; De Palma, A.; Secundo, F.; Benazzi, L.; Valtorta, M.; Tortora, P.; Fusi, P.
Ataxin-3 is subject to autolytic cleavage
FEBS J.
273
4277-4286
2006
Mus musculus (Q9CVD2)
Vigneswara, V.; Lowenson, J.D.; Powell, C.D.; Thakur, M.; Bailey, K.; Clarke, S.; Ray, D.E.; Carter, W.G.
Proteomic identification of novel substrates of a protein isoaspartyl methyltransferase repair enzyme
J. Biol. Chem.
281
32619-32629
2006
Mus musculus (Q9R0P9)
Butterworth, M.B.; Edinger, R.S.; Ovaa, H.; Burg, D.; Johnson, J.P.; Frizzell, R.A.
The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel
J. Biol. Chem.
282
37885-37893
2007
Mus musculus
Fujino, R.S.; Ishikawa, Y.; Tanaka, K.; Kanatsu-Shinohara, M.; Tamura, K.; Kogo, H.; Shinohara, T.; Hara, T.
Capillary morphogenesis gene (CMG)-1 is among the genes differentially expressed in mouse male germ line stem cells and embryonic stem cells
Mol. Reprod. Dev.
73
955-966
2006
Mus musculus, Mus musculus DBA/2
Sun, J.; Ying, M.; Li, H.; Shang, X.; He, Y.; Chen, K.; Cheng, H.; Zhou, R.
Role of UCH-L1/ubiquitin in acute testicular ischemia-reperfusion injury
Biochem. Biophys. Res. Commun.
366
539-544
2008
Mus musculus (Q9R0P9), Mus musculus
Vasu, V.T.; Ott, S.; Hobson, B.; Rashidi, V.; Oommen, S.; Cross, C.E.; Gohil, K.
Sarcolipin and ubiquitin carboxy-terminal hydrolase 1 mRNAs are over-expressed in skeletal muscles of alpha-tocopherol deficient mice
Free Radic. Res.
43
106-116
2009
Mus musculus (Q9R0P9)
Jin, W.; Chang, M.; Paul, E.M.; Babu, G.; Lee, A.J.; Reiley, W.; Wright, A.; Zhang, M.; You, J.; Sun, S.C.
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice
J. Clin. Invest.
118
1858-1866
2008
Mus musculus (Q80TQ2)
Lu, Y.; Adegoke, O.A.; Nepveu, A.; Nakayama, K.I.; Bedard, N.; Cheng, D.; Peng, J.; Wing, S.S.
USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1
Mol. Cell. Biol.
29
547-558
2009
Mus musculus (Q3UJD6), Rattus norvegicus (Q6J1Y9)
Setsuie, R.; Sakurai, M.; Sakaguchi, Y.; Wada, K.
Ubiquitin dimers control the hydrolase activity of UCH-L3
Neurochem. Int.
54
314-321
2009
Homo sapiens (P09936), Homo sapiens (P15374), Mus musculus (Q9JKB1), Mus musculus (Q9R0P9)
Fang, Y.; Fu, D.; Shen, X.Z.
The potential role of ubiquitin C-terminal hydrolases in oncogenesis
Biochim. Biophys. Acta
1806
1-6
2010
Homo sapiens, Mus musculus
Suzuki, M.; Setsuie, R.; Wada, K.
Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis
Endocrinology
150
5230-5239
2009
Mus musculus
Pfeffer, M.; Plenzig, S.; Gispert, S.; Wada, K.; Korf, H.W.; Von Gall, C.
Disturbed sleep/wake rhythms and neuronal cell loss in lateral hypothalamus and retina of mice with a spontaneous deletion in the ubiquitin carboxyl-terminal hydrolase L1 gene
Neurobiol. Aging
33
393-403
2012
Mus musculus
Goto, A.; Wang, Y.L.; Kabuta, T.; Setsuie, R.; Osaka, H.; Sawa, A.; Ishiura, S.; Wada, K.
Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (gad) mouse
Neurochem. Int.
54
330-338
2009
Mus musculus
Setsuie, R.; Suzuki, M.; Tsuchiya, Y.; Wada, K.
Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses
Neurochem. Int.
56
911-918
2010
Mus musculus
Nagamine, S.; Kabuta, T.; Furuta, A.; Yamamoto, K.; Takahashi, A.; Wada, K.
Deficiency of ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) leads to vulnerability to lipid peroxidation
Neurochem. Int.
57
102-110
2010
Mus musculus, Mus musculus C57/BL6J
Bheda, A.; Yue, W.; Gullapalli, A.; Whitehurst, C.; Liu, R.; Pagano, J.S.; Shackelford, J.
Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling
PLoS ONE
4
e5955
2009
Homo sapiens, Mus musculus
Bheda, A.; Shackelford, J.; Pagano, J.S.
Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes
PLoS ONE
4
e6764
2009
Mus musculus
Liu, Z.; Meray, R.K.; Grammatopoulos, T.N.; Fredenburg, R.A.; Cookson, M.R.; Liu, Y.; Logan, T.; Lansbury, P.T.
Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinsons disease
Proc. Natl. Acad. Sci. USA
106
4635-4640
2009
Homo sapiens, Mus musculus
Chen, F.; Sugiura, Y.; Myers, K.G.; Liu, Y.; Lin, W.
Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction
Proc. Natl. Acad. Sci. USA
107
1636-1641
2010
Mus musculus
Day, I.N.; Thompson, R.J.
UCHL1 (PGP 9.5): neuronal biomarker and ubiquitin system protein
Prog. Neurobiol.
90
327-362
2010
Bos taurus, Homo sapiens, Macaca fuscata, Mus musculus, Rattus norvegicus
Gu, Y.Q.; Chen, Q.J.; Gu, Z.; Shi, Y.; Yao, Y.W.; Wang, J.; Sun, Z.G.; Tso, J.K.
Ubiquitin carboxyl-terminal hydrolase L1 contributes to the oocyte selective elimination in prepubertal mouse ovaries
Sheng Li Xue Bao
61
175-184
2009
Mus musculus, Mus musculus ICR
Ko, Y.M.; Chang, C.Y.; Chiou, S.J.; Hsu, F.J.; Huang, J.S.; Yang, Y.L.; Guh, J.Y.; Chuang, L.Y.
Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-beta receptor I expression and hypertrophy in mesangial cells
Arch. Biochem. Biophys.
535
177-186
2013
Mus musculus
Read, N.C.; Gutsol, A.; Holterman, C.E.; Carter, A.; Coulombe, J.; Gray, D.A.; Kennedy, C.R.
Ubiquitin C-terminal hydrolase L1 deletion ameliorates glomerular injury in mice with ACTN4-associated focal segmental glomerulosclerosis
Biochim. Biophys. Acta
1842
1028-1040
2014
Mus musculus
Hartnett, S.; Zhang, F.; Abitz, A.; Li, Y.
Ubiquitin C-terminal hydrolase L1 interacts with choline transporter in cholinergic cells
Neurosci. Lett.
564
115-119
2014
Mus musculus (Q9R0P9)
Gao, H.; Hartnett, S.; Li, Y.
Ubiquitin C-terminal hydrolase L1 regulates myoblast proliferation and differentiation
Biochem. Biophys. Res. Commun.
492
96-102
2017
Mus musculus (Q9R0P9), Mus musculus
Bishop, P.; Rocca, D.; Henley, J.M.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) structure, distribution and roles in brain function and dysfunction
Biochem. J.
473
2453-2462
2016
Homo sapiens (P09936), Mus musculus (Q9R0P9)
Radon, V.; Czesla, M.; Reichelt, J.; Fehlert, J.; Hammel, A.; Rosendahl, A.; Knop, J.H.; Wiech, T.; Wenzel, U.O.; Sachs, M.; Reinicke, A.T.; Stahl, R.A.K.; Meyer-Schwesinger, C.
Ubiquitin C-terminal hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney
Kidney Int.
93
110-127
2018
Mus musculus (Q9R0P9)
