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Information on EC - arylsulfatase (type I)

for references in articles please use BRENDA:EC3.1.6.1

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IUBMB Comments

Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-β-lactamase fold and binds two zinc ions as cofactors. Arylsulfatases are type I enzymes, found in both prokaryotes and eukaryotes, with rather similar specificities. The key catalytic residue 3-oxo-L-alanine initiates the reaction through a nucleophilic attack on the sulfur atom in the substrate. This residue is generated by posttranslational modification of a conserved cysteine or serine residue by EC, formylglycine-generating enzyme, EC, serine-type anaerobic sulfatase-maturating enzyme, or EC, cysteine-type anaerobic sulfatase-maturating enzyme.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

sulfatase, arylsulfatase a, arylsulfatase, arylsulphatase, arylsulfatase b, arylsulphatase a, estrogen sulfatase, ars-a, arylsulfatase e, arylsulfatase g, more

an aryl sulfate + H2O = a phenol + sulfate
show the reaction diagram