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Information on EC 3.1.3.27 - phosphatidylglycerophosphatase
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3.1.3.27 phosphatidylglycerophosphataseSpecify your search results
Word Map
- 3.1.3.27
- phosphatidylglycerol
- cardiolipin
- mitochondrion
-
phosphatidylglycerolphosphate
- alexidine
-
pten-like
-
dual-specificity
- synthesis
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
At3g58830, At5g56610, PGP phosphatase, PGP-A, PGP-B, PGP-C, PGP-tase, PGPA-tase, PGPase, PgpB, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
PGP phosphatase
PGPase
PgpB
Pgpp1
phosphatidylglycerophosphate phosphatase B
PTPMT1
YodM
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
phosphatidylglycerophosphate phosphohydrolase
-
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CAS REGISTRY NUMBER
COMMENTARY
9033-46-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate
1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O
1,2-dihexadecanoyl-sn-glycerol + phosphate
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O
1-(9Z-octadecenoyl)-sn-glycerol + phosphate
dipalmitoyl sn-glycero 3-phosphate + H2O
dipalmitoyl sn-glycerol + phosphate
-
-
-
r
phosphatidylglycerophosphate + H2O
3-phosphatidylglycerol + phosphate
-
-
-
?
(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol-1-phosphate + H2O
?
-
-
-
?
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate
-
-
-
?
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate
-
-
-
?
1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O
1,2-dihexadecanoyl-sn-glycerol + phosphate
-
-
-
?
1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O
1,2-dihexadecanoyl-sn-glycerol + phosphate
-
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphate + H2O
1,2-dioleoyl-sn-glycerol + phosphate
highest activity
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphate + H2O
1,2-dioleoyl-sn-glycerol + phosphate
Escherichia coli B / ATCC 11303
highest activity
-
-
?
1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1'-(3'-phospho)glycerol)] + H2O
? + phosphate
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1'-(3'-phospho)glycerol)] + H2O
? + phosphate
-
-
-
?
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O
1-(9Z-octadecenoyl)-sn-glycerol + phosphate
-
-
-
?
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O
1-(9Z-octadecenoyl)-sn-glycerol + phosphate
-
-
-
?
1-hexanoyl-sn-glycero-3-phosphate + H2O
1-hexanoyl-sn-glycerol + phosphate
-
-
-
?
1-hexanoyl-sn-glycero-3-phosphate + H2O
1-hexanoyl-sn-glycerol + phosphate
-
-
-
?
1-oleoyl-2-lyso-sn-glycero-3-phosphate + H2O
1-oleoyl-2-lyso-sn-glycerol + phosphate
-
-
-
?
1-oleoyl-2-lyso-sn-glycero-3-phosphate + H2O
1-oleoyl-2-lyso-sn-glycerol + phosphate
Escherichia coli B / ATCC 11303
-
-
-
?
isopentenyldiphosphate + H2O
isopentenylphosphate + phosphate
-
-
-
?
isopentenyldiphosphate + H2O
isopentenylphosphate + phosphate
-
-
-
?
phosphatidylglycerol 3-phosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
-
?
phosphatidylglycerol 3-phosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
-
?
phosphatidylglycerol 3-phosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
Micrococcus cerificans
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
Q84VV0
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
hydrolysis of other simple phosphomonoesters not catalyzed
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
r
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
Micrococcus cerificans
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
r
undecaprenyldiphosphate + H2O
undecaprenylphosphate + phosphate
-
-
-
?
undecaprenyldiphosphate + H2O
undecaprenylphosphate + phosphate
-
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
Micrococcus cerificans
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
-
each protomer contains an independent active site with two metal ions, Ca2+ and Mg2+, forming a heterobinuclear center located in a hydrophilic cavity near the surface of the molecule
Mg2+
Mg2+
-
each protomer contains an independent active site with two metal ions, Ca2+ and Mg2+, forming a heterobinuclear center located in a hydrophilic cavity near the surface of the molecule
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NaF
-
80% loss of activity with 5 mM in compound fraction of PGP-A, PGP-B and PGP-C
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Insulinoma
Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells.
Leukemia, Erythroblastic, Acute
Ptpmt1 induced by HIF-2? regulates the proliferation and glucose metabolism in erythroleukemia cells.
Lung Neoplasms
SRSF1 modulates PTPMT1 alternative splicing to regulate lung cancer cell radioresistance.
Lymphocytic Choriomeningitis
Long-lived signal peptide of lymphocytic choriomeningitis virus glycoprotein pGP-C.
Mitochondrial Diseases
A mitochondrial phosphatase PTPMT1 is essential for the early development of silkworm, Bombyx mori.
Mycoses
Structure and antifungal activity of pelgipeptins from Paenibacillus elgii against phytopathogenic fungi.
Neoplasms
Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death.
Neoplasms
SRSF1 modulates PTPMT1 alternative splicing to regulate lung cancer cell radioresistance.
Obesity
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.
phosphatidylglycerophosphatase deficiency
Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation.
phosphatidylglycerophosphatase deficiency
Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis.
Starvation
FoxO1 localizes to mitochondria of adipose tissue and is affected by nutrient stress.
Vaccinia
Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.3
1,2-dioleoyl-sn-glycero-3-phosphate
pH and temperature not specified in the publication
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
24
1,2-dioleoyl-sn-glycero-3-phosphate
pH and temperature not specified in the publication
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
54.7
substrate 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate), pH 7.4, 37°C
6
-
PGPA-tase, more specific for phosphatidylglycerolphosphate than PGPB-tase
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
weak association to the mitochondrial membrane
brenda
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
-
phosphatidylglycerophosphate phosphatase essential for the biosynthesis of cardiolipin, an integral component of mitochondrial and bacterial membranes
physiological function
physiological function
enzyme is the principal phosphatidylglycerol phosphate phosphatase of Bacillus subtilis. Gene expression complements both undecaprenylphosphate and phosphatidylglycerol metabolisms in Escherichia coli mutant strains
physiological function
expression of Ptpmt1 gene complements the phenotype of a yeast PGPP mutant. A Pgpp1 Ptpmt1 Ptpmt2 mutant significantly enhances the root phenotype of the Pgpp1 mutant without further affecting the photosynthesis
physiological function
expression of Ptpmt2 gene complements the phenotype of a yeast PGPP mutant. A Pgpp1 Ptpmt1 Ptpmt2 mutant significantly enhances the root phenotype of the Pgpp1 mutant without further affecting the photosynthesis
physiological function
Q84VV0
mutant plants lacking phosphatidylglycerophosphate phosphatase activity contain reduced amounts of chlorophyll, but photosynthetic quantum yield remains unchanged. The absolute content of plastidial phosphatidylglycerol (34:4; total number of acyl carbons:number of double bonds) is reduced by about 1/3. Expression of Pgpp1 gene complements the defect of a yeast Gep4 mutant
physiological function
mutants defective in Pgpp1 display considerably shorter roots, due to defective order of columella cells in the root apices. A Pgpp1 Ptpmt1 Ptpmt2 mutant additionally lacking mitochondria-localized phosphatases significantly enhances the root phenotype of the Pgpp1 mutant without further affecting the photosynthesis
physiological function
-
enzyme is the principal phosphatidylglycerol phosphate phosphatase of Bacillus subtilis. Gene expression complements both undecaprenylphosphate and phosphatidylglycerol metabolisms in Escherichia coli mutant strains
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
structure at 2.25 A resolution, with phosphate analogue tungstate in the active site. The structure reveals two lipid chains in the active site vicinity
vapor diffusion method, the structure is determined at 3.2 A resolution
with precipitant containing 30% pentaerythritol ethoxylate, 50 mM ammonium sulfate, 50 mM Bis-Tris at pH 6.5
-