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Information on EC 3.1.3.27 - phosphatidylglycerophosphatase
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3.1.3.27 phosphatidylglycerophosphataseSpecify your search results
Word Map
- 3.1.3.27
- cardiolipin
- phosphatidylglycerol
-
pten-like
-
phosphatidylglycerolphosphate
- alexidine
-
dual-specificity
- synthesis
The enzyme appears in viruses and cellular organisms
Synonyms
ptpmt1, pgp phosphatase, pgp-c, pgpp1, phosphatidylglycerophosphatase, phosphatidylglycerophosphate phosphohydrolase, pgp-a, ptpmt2, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
PGP phosphatase
PGPase
PgpB
Pgpp1
phosphatidylglycero phosphate phosphatase
-
-
-
-
phosphatidylglycerophosphate phosphatase B
PTPMT1
YodM
PGP phosphatase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
phosphatidylglycerophosphate phosphohydrolase
-
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CAS REGISTRY NUMBER
COMMENTARY
9033-46-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate
1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O
1,2-dihexadecanoyl-sn-glycerol + phosphate
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O
1-(9Z-octadecenoyl)-sn-glycerol + phosphate
dipalmitoyl sn-glycero 3-phosphate + H2O
dipalmitoyl sn-glycerol + phosphate
-
-
-
r
phosphatidylglycerophosphate + H2O
3-phosphatidylglycerol + phosphate
-
-
-
?
(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol-1-phosphate + H2O
?
-
-
-
?
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate
-
-
-
?
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate
-
-
-
?
1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O
1,2-dihexadecanoyl-sn-glycerol + phosphate
-
-
-
?
1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O
1,2-dihexadecanoyl-sn-glycerol + phosphate
-
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphate + H2O
1,2-dioleoyl-sn-glycerol + phosphate
highest activity
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphate + H2O
1,2-dioleoyl-sn-glycerol + phosphate
Escherichia coli B / ATCC 11303
highest activity
-
-
?
1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1'-(3'-phospho)glycerol)] + H2O
? + phosphate
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1'-(3'-phospho)glycerol)] + H2O
? + phosphate
-
-
-
?
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O
1-(9Z-octadecenoyl)-sn-glycerol + phosphate
-
-
-
?
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O
1-(9Z-octadecenoyl)-sn-glycerol + phosphate
-
-
-
?
1-hexanoyl-sn-glycero-3-phosphate + H2O
1-hexanoyl-sn-glycerol + phosphate
-
-
-
?
1-hexanoyl-sn-glycero-3-phosphate + H2O
1-hexanoyl-sn-glycerol + phosphate
-
-
-
?
1-oleoyl-2-lyso-sn-glycero-3-phosphate + H2O
1-oleoyl-2-lyso-sn-glycerol + phosphate
-
-
-
?
1-oleoyl-2-lyso-sn-glycero-3-phosphate + H2O
1-oleoyl-2-lyso-sn-glycerol + phosphate
Escherichia coli B / ATCC 11303
-
-
-
?
isopentenyldiphosphate + H2O
isopentenylphosphate + phosphate
-
-
-
?
isopentenyldiphosphate + H2O
isopentenylphosphate + phosphate
-
-
-
?
phosphatidylglycerol 3-phosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
-
?
phosphatidylglycerol 3-phosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
-
?
phosphatidylglycerol 3-phosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
Micrococcus cerificans
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
Q84VV0
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
hydrolysis of other simple phosphomonoesters not catalyzed
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
r
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
Micrococcus cerificans
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
?
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
r
undecaprenyldiphosphate + H2O
undecaprenylphosphate + phosphate
-
-
-
?
undecaprenyldiphosphate + H2O
undecaprenylphosphate + phosphate
-
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
phosphatidylglycerophosphate + H2O
phosphatidylglycerol + phosphate
-
-
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
Micrococcus cerificans
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
phosphatidylglycerophosphate + H2O
?
-
biosynthesis of phospholipids
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
-
each protomer contains an independent active site with two metal ions, Ca2+ and Mg2+, forming a heterobinuclear center located in a hydrophilic cavity near the surface of the molecule
Mg2+
Mg2+
-
each protomer contains an independent active site with two metal ions, Ca2+ and Mg2+, forming a heterobinuclear center located in a hydrophilic cavity near the surface of the molecule
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NaF
-
80% loss of activity with 5 mM in compound fraction of PGP-A, PGP-B and PGP-C
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
Splicing factor SRSF1 promotes breast cancer progression via oncogenic splice switching of PTPMT1.
Insulinoma
Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells.
Leukemia, Erythroblastic, Acute
Ptpmt1 induced by HIF-2? regulates the proliferation and glucose metabolism in erythroleukemia cells.
Liver Neoplasms
Genome-wide CRISPR-Cas9 knockout library screening identified PTPMT1 in cardiolipin synthesis is crucial to survival in hypoxia in liver cancer.
Lung Neoplasms
SRSF1 modulates PTPMT1 alternative splicing to regulate lung cancer cell radioresistance.
Lymphocytic Choriomeningitis
Long-lived signal peptide of lymphocytic choriomeningitis virus glycoprotein pGP-C.
Mitochondrial Diseases
A mitochondrial phosphatase PTPMT1 is essential for the early development of silkworm, Bombyx mori.
Mycoses
Structure and antifungal activity of pelgipeptins from Paenibacillus elgii against phytopathogenic fungi.
Neoplasms
Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death.
Neoplasms
Genome-wide CRISPR-Cas9 knockout library screening identified PTPMT1 in cardiolipin synthesis is crucial to survival in hypoxia in liver cancer.
Neoplasms
SRSF1 modulates PTPMT1 alternative splicing to regulate lung cancer cell radioresistance.
Obesity
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.
phosphatidylglycerophosphatase deficiency
Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation.
phosphatidylglycerophosphatase deficiency
Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis.
Starvation
FoxO1 localizes to mitochondria of adipose tissue and is affected by nutrient stress.
Vaccinia
Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.3
1,2-dioleoyl-sn-glycero-3-phosphate
pH and temperature not specified in the publication
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
24
1,2-dioleoyl-sn-glycero-3-phosphate
pH and temperature not specified in the publication
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
54.7
substrate 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate), pH 7.4, 37°C
6
-
PGPA-tase, more specific for phosphatidylglycerolphosphate than PGPB-tase
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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