Ligand phosphatidylglycerol

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Basic Ligand Information

Molecular Structure
Picture of phosphatidylglycerol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C14H25O10PR2
phosphatidylglycerol
LCLHHZYHLXDRQG-MKJFYJHKSA-N
Synonyms:
3(3-phosphatidyl-)glycerol, 3-phosphatidylglycerol, a phosphatidyl-glycerol, a phosphatidylglycerol, L-alpha-phosphatidyl-DL-glycerol, phosphatidyl glycerol
Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for phosphatidylglycerol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-alanyl-tRNAAla + phosphatidylglycerol = tRNAAla + 3-O-L-alanyl-1-O-phosphatidylglycerol
show the reaction diagram
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phosphatidylglycerol + membrane-derived oligosaccharide D-glucose = sn-1,2-diacylglycerol + beta-D-glucoside-6-phosphoglycerol
show the reaction diagram
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a phosphatidylglycerol + a phosphatidylglycerol = a cardiolipin + glycerol
show the reaction diagram
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a phosphatidylglycerol + a phosphatidylethanolamine = a cardiolipin + ethanolamine
show the reaction diagram
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phosphatidylglycerol + H2O = ?
show the reaction diagram
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phosphatidylglycerol + H2O = glycerol + phosphatidic acid
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (39 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + phosphatidylglycerol = S-adenosyl-L-homocysteine + ?
show the reaction diagram
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S-adenosyl-L-methionine + phosphatidylglycerol = S-adenosyl-L-homocysteine + ?
show the reaction diagram
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phosphatidylglycerol + [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine = 1-lyso-phosphatidylglycerol + [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
show the reaction diagram
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a phosphatidylglycerol + a phosphatidylethanolamine = a cardiolipin + ethanolamine
show the reaction diagram
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phosphatidylglycerol + H2O = ?
show the reaction diagram
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phosphatidylglycerol + H2O = ?
show the reaction diagram
-
phosphatidylglycerol + H2O = ?
show the reaction diagram
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phosphatidylglycerol + H2O = 1-acylglycerol + fatty acid
show the reaction diagram
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phosphatidylglycerol + H2O = lysophosphatidylglycerol + a carboxylate
show the reaction diagram
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phosphatidylglycerol + H2O = diacylglycerol + glycerolphosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CDP-diacylglycerol + glycerol = CMP + phosphatidylglycerol
show the reaction diagram
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phosphatidylcholine + glycerol = phosphatidylglycerol + choline
show the reaction diagram
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phosphatidylglycerol phosphate + H2O = phosphatidylglycerol + phosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (63 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
micelles, activation, in presence of Triton X-100, slight stimulation at low concentrations
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increases Vmax
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anionic amphiphiles are essential for the restoration of a proper conformation. Amphiphilic environment with a critical fraction of negatively charged headgroups induces a catalytic, active site conformation of the enzyme
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activation
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best activator of partially purified, delipidated enzyme
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requirement
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relative activity: 356%
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activation
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presence of 10 mM in assay, enhances activity
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marked effect in activating lipid-depleted enzyme
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activates, phosphorylation of beta2-AR
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slightly stimulating
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activity is stimulated 5-10fold by inclusion of 0.1 mg/ml in both radiochemical and fluorescence enhancement assays
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stimulates 4fold 0.36 mM
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membrane association and activity of PtdSer synthase is increased, studied with mixed micelles containing phosphatidylglycerol (one charge) or diphosphatidylglycerol (two charges), the two main anionic membrane lipids in Escherichia coli
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increases hydrolytic activity
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highly activating
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essential for optimal activity, responsible for a better solubilization of the substrate by CHAPS. The possibility of a specidic role as aphysiological activator cannot be ruled out
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increases the film pressure of the phosphatidylinositol monolayer at an air/water interface at which cut-off occurs, as well as increases the rate of hydrolysis at lower pressures
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stimulation
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concentrations of 0.002-0.05 mM
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stimulates
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binding to nonsubstrate anionic interfaces enhances the catalytic activity of PI-PLC, interfacial binding studies, activation mechanism
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the hydrolytic activity of CopA is stimulated by phosphoholipid cardiolipin and to some extent by phosphatidylglycerol
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via the EpsE/cyto-EpsL complex
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slight activation
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Inhibitor in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
at high concentrations
-
perturbs the intrinsic PSII electron transport, leading to a dissociation of the inner antenna protein CP43 and the 27- and 25-kDa apoproteins of the light-harvesting complex II. Influence is much less than sulfoquinovosyldiacylglycerol
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above 1.5 mM, activation below
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inhibits in excess amount
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inhibits phosphatidylcholine-dependent kinase activity
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and sulfoquinovosyldiacylglycerol, inactivation in a cooperative manner
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0.7 mg/ml, 75% inhibition
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strong
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inhibits activity at 50-55°C
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ceramide synthesis activity, 10 mol%, moderate inhibition
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ATP-binding subunit HisP with a carboxy-terminal extension of 8 amino acids
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Enzyme Kinetic Parameters

KM Value (5 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.056
-
-
0.0003
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References & Links

Links to other databases for phosphatidylglycerol

ChEBI
PubChem
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PubChem