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Information on EC 3.1.1.3 - triacylglycerol lipase and Organism(s) Homo sapiens

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.3 triacylglycerol lipase
IUBMB Comments
The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolysed.
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Select one or more organisms in this record:
This record set is specific for:
Homo sapiens
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
acid lipase, acidic lipase, acylglycerol acylhydrolase, acyltransferase, adipocyte triglyceride lipase, adipose TG lipase, adipose triglyceride lipase, AFL1-1, Alip1p, alkaline lipase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
adipose TG lipase
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adipose triglyceride lipase
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amano AP
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amano B
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amano CE
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amano CES
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amano P
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amno N-AP
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BAL
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Bile-salt-stimulated lipase
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BSSL
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butyrinase
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cacordase
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CALB
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capalase L
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Carboxyl ester lipase
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cholesterol esterase
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Cytotoxic T lymphocyte lipase
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desnutrin
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EDL
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Endothelial cell-derived lipase
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endothelial lipase
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Endothelial-derived lipase
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GA 56 (enzyme)
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Gastric lipase
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GEH
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glycerol ester hydrolase
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glycerol-ester hydrolase
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heparin releasable hepatic lipase
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hepatic lipase
hepatic monoacylglycerol acyltransferase
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hormone sensitive lipase
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hormone-sensitive lipase
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HPLRP2
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Lingual lipase
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lipase
lipase, triacylglycerol
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lipazin
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lipoprotein lipase
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hydrolyzes triglycerides in chylomicrons and very low density lipoprotein particles
liver lipase
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meito MY 30
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meito Sangyo OF lipase
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Pancreatic lipase
pancreatic lipase-related protein 2
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Pancreatic lysophospholipase
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pancreatic triacylglycerol lipase
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pancreatic triglyceride lipase
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PGE
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phospholipase A2xi
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PL-RP2
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post-heparin plasma protamine-resistant lipase
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PPL
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Pregastric esterase
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Pregastric lipase
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salt-resistant post-heparin lipase
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steapsin
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Sterol esterase
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TAG lipase
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takedo 1969-4-9
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teenesterase
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TG hydrolase
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TG lipase
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tiacetinase
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tibutyrin esterase
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triacylglycerol acylhydrolase
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triacylglycerol ester hydrolase
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triacylglycerol hydrolase
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Triacylglycerol lipase
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tributyrase
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tributyrinase
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triglyceridase
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triglyceride hydrolase
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triglyceride lipase
triolein hydrolase
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tween hydrolase
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tween-hydrolyzing esterase
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Tweenase
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additional information
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
triacylglycerol + H2O = diacylglycerol + a carboxylate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of carboxylic ester
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SYSTEMATIC NAME
IUBMB Comments
triacylglycerol acylhydrolase
The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolysed.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-62-1
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,3-dibutyrylthio-1-propyl oleate + H2O
2,3-dibutyrylthiopropyl alcohol + oleate
show the reaction diagram
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chromogenic detection using 5,5'-dithio-bis-(2-nitrobenzoic acid) as chromogen or the 6-methylresorufin ester of 1-O,2-dilauryl-rac-glycero-3-glutaric acid, substrate synthesis, assay development, optimization, and method comparison, overview
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?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
show the reaction diagram
diolein + H2O
monoolein + oleate
show the reaction diagram
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?
L-alpha-phosphatidylcholine + H2O
?
show the reaction diagram
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?
olive oil + H2O
?
show the reaction diagram
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?
triacylglycerol + H2O
diacylglycerol + a carboxylate
show the reaction diagram
tributyrin + H2O
?
show the reaction diagram
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?
tributyrin + H2O
butyric acid + ?
show the reaction diagram
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?
tributyrin + H2O
dibutyrin + butyrate
show the reaction diagram
tricaprylin + H2O
dicaprylin + caprylate
show the reaction diagram
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?
trioctanoin + H2O
dioctanoin + octanoate
show the reaction diagram
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?
trioctanoin + H2O
octanoic acid + ?
show the reaction diagram
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?
triolein + H2O
diolein + oleate
show the reaction diagram
trioleoylglycerol + H2O
oleic acid + ?
show the reaction diagram
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?
additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
show the reaction diagram
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recombinant enzyme in Sf9 cells
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?
triacylglycerol + H2O
diacylglycerol + a carboxylate
show the reaction diagram
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Colipase
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
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activates the phospholipase A1 activity of the enzyme, overview
Mg2+
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NaCl
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-hexadecenoic acid
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aurantiamide
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Bile salts
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cnidiadin
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orlistat
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sodium taurodeoxycholate
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additional information
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changes in HDL cholesteryl ester and fatty acid content have no effect on hepatic lipase displacement, increases in HDL phospholipid and TG content significantly inhibit hepatic lipase displacement
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
bile salt
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pancreatic lipase, stimulation
CGI-58
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Colipase
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dilinoleoylphosphatidylcholine
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promotes hepatic lipase liberation from cell surface proteoglycans
HDL
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HDL is able to displace cell surface-bound hepatic lipase and stimulate vascular triglyceride hydrolysis, much like heparin. HDL fractions from hyperlipidemic patients are unable to displace HL from the cell surface
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heparin
high-density lipoprotein
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HDL, acts much like heparin to liberate hepatic lipase from cell surface proteoglycans and stimulate triglyceride clearance
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perilipin A
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phosphorylation of perilipin specifically at serine 517 by protein kinase A is essential for ATGL activation, overview
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sodium taurodeoxycholate
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