Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation at Ser506 activates the enzyme by 100-140% | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, the genes encoding the enzyme are located on chromosome 8 within a cluster of carboxylesterase genes, genetic organization, expression analysis | Mus musculus |
the genes encoding the enzyme are located on chromosome 16 within a cluster of carboxylesterase genes, genetic organization, expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a perilipin-regulation mutant shows increased enzyme activity in adipose tissue and increased lipolysis leading to lean mice | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
endoplasmic reticulum | - |
Sus scrofa | 5783 | - |
endoplasmic reticulum | - |
Bos taurus | 5783 | - |
lipid droplet | - |
Mus musculus | 5811 | - |
lipid droplet | - |
Homo sapiens | 5811 | - |
lipid droplet | - |
Rattus norvegicus | 5811 | - |
lipid droplet | - |
Sus scrofa | 5811 | - |
lipid droplet | - |
Bos taurus | 5811 | - |
microsome | - |
Mus musculus | - |
- |
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Sus scrofa | - |
- |
microsome | - |
Bos taurus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | ? | - |
? | |
additional information | Rattus norvegicus | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | ? | - |
? | |
additional information | Sus scrofa | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | ? | - |
? | |
additional information | Bos taurus | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | ? | - |
? | |
additional information | Mus musculus | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, the hormone-sensitive lipase is negatively regulated by perilipin in adipose tissue, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | posttranslational regulation by N-glycosylation at Asn79 | Homo sapiens |
glycoprotein | posttranslational regulation by N-glycosylation at Asn79 and Asn489 | Mus musculus |
phosphoprotein | a phosphorylation site is Ser506, phosphorylation activates the enzyme | Rattus norvegicus |
phosphoprotein | phosphorylation sites are Tyr218 and at seven Ser/Thr consensus sequences | Homo sapiens |
Purification (Comment) | Organism |
---|---|
from liver microsomes | Mus musculus |
from liver microsomes | Homo sapiens |
from liver microsomes | Sus scrofa |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
triacylglycerol + H2O = diacylglycerol + a carboxylate | activation mechanism | Rattus norvegicus | |
triacylglycerol + H2O = diacylglycerol + a carboxylate | active site structure, reaction mechanism | Mus musculus | |
triacylglycerol + H2O = diacylglycerol + a carboxylate | active site structure, reaction mechanism | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | hormone-sensitive lipase is negatively regulated by perilipin, lipolysis of storage triacylglycerides | Mus musculus | - |
adipocyte | hormone-sensitive lipase, lipolysis of storage triacylglycerides | Homo sapiens | - |
adipocyte | hormone-sensitive lipase, lipolysis of storage triacylglycerides | Rattus norvegicus | - |
adipocyte | hormone-sensitive lipase, lipolysis of storage triacylglycerides | Sus scrofa | - |
adipocyte | hormone-sensitive lipase, lipolysis of storage triacylglycerides | Bos taurus | - |
heart | - |
Mus musculus | - |
heart | - |
Rattus norvegicus | - |
kidney | - |
Mus musculus | - |
kidney | - |
Rattus norvegicus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Sus scrofa | - |
liver | - |
Bos taurus | - |
liver | regulation of enzyme expression, transcription factor binding, overview | Mus musculus | - |
macrophage | - |
Homo sapiens | - |
additional information | no expression in brain, skeletal muscle, or spleen, tissue-specific functions, expression is developmentally regulated, detailed overview | Mus musculus | - |
additional information | tissue-specific functions, expression is developmentally regulated, detailed overview | Homo sapiens | - |
additional information | tissue-specific functions, expression is developmentally regulated, detailed overview | Rattus norvegicus | - |
additional information | tissue-specific functions, expression is developmentally regulated, detailed overview | Sus scrofa | - |
additional information | tissue-specific functions, expression is developmentally regulated, detailed overview | Bos taurus | - |
small intestine | - |
Mus musculus | - |
small intestine | - |
Homo sapiens | - |
small intestine | - |
Rattus norvegicus | - |
testis | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | Homo sapiens | ? | - |
? | |
additional information | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | Rattus norvegicus | ? | - |
? | |
additional information | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | Sus scrofa | ? | - |
? | |
additional information | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | Bos taurus | ? | - |
? | |
additional information | the enzyme is involved in basal lipolysis of storage triacylglycerides, and hormonally as well as developmentally regulated, the hormone-sensitive lipase is negatively regulated by perilipin in adipose tissue, physiological functions, role in apoB-containing lipoprotein assembly in the endoplasmic reticulum, overview | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | secondary and three-dimensional structure analysis, overview | Mus musculus |
More | secondary and three-dimensional structure analysis, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
hormone-sensitive lipase | - |
Mus musculus |
hormone-sensitive lipase | - |
Homo sapiens |
hormone-sensitive lipase | - |
Rattus norvegicus |
hormone-sensitive lipase | - |
Sus scrofa |
hormone-sensitive lipase | - |
Bos taurus |
HSL | - |
Mus musculus |
HSL | - |
Homo sapiens |
HSL | - |
Rattus norvegicus |
HSL | - |
Sus scrofa |
HSL | - |
Bos taurus |
TGH | - |
Mus musculus |
TGH | - |
Homo sapiens |
TGH | - |
Rattus norvegicus |
TGH | - |
Sus scrofa |
TGH | - |
Bos taurus |
triacylglycerol hydrolase | - |
Mus musculus |
triacylglycerol hydrolase | - |
Homo sapiens |
triacylglycerol hydrolase | - |
Rattus norvegicus |
triacylglycerol hydrolase | - |
Sus scrofa |
triacylglycerol hydrolase | - |
Bos taurus |