Literature summary for 3.1.1.3 extracted from

Schweiger, M.; Schoiswohl, G.; Lass, A.; Radner, F.P.; Haemmerle, G.; Malli, R.; Graier, W.; Cornaciu, I.; Oberer, M.; Salvayre, R.; Fischer, J.; Zechner, R.; Zimmermann, R.
The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding (2008), J. Biol. Chem., 283, 17211-17220.

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Activating Compound

Activating Compound	Comment	Organism	Structure
CGI-58	the enzyme requires the activator protein (or ABHD5) for full enzymatic activity	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in COS-7 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
FS270	mutant exhibits increased activity (2.0fold more active compared to the wild type enzyme)	Homo sapiens
FS282	mutant exhibits increased activity (7.6fold more active compared to the wild type enzyme)	Homo sapiens
P195L	the mutant exhibits reduced activity and is associated with neutral lipid storage disease that is characterized by systemic triglycerol accumulation and myopathy	Homo sapiens
Q289X	mutant exhibits increased activity (24.6fold more active compared to the wild type enzyme)	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
additional information	the wild type enzyme is barely detectable in the cytosol	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adipocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
triolein + H2O	-	Homo sapiens	diolein + oleate	-	?

Synonyms

Synonyms	Comment	Organism
adipose triglyceride lipase	-	Homo sapiens
ATGL	-	Homo sapiens

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Release 2023.1 (January 2023)