EC Number   |
General Information |
Reference |
|---|
    3.1.1.3 | malfunction |
ATGL-deficiency decreases the release of fatty acids from white adipose tissue by about 70% in response to isoproterenol treatment, and this decreased lipolytic rate results in substantially reduced plasma fatty acid levels in ATGL-KO mice. Moreover, ATGL deficient mice are extremely cold-sensitive. Upon fasting, they reduce their oxygen consumption and drop their body temperature, phenotype, overview |
707547 |
| 3.1.1.3 | malfunction |
enzyme-deficient mice show an increased utilization of carbohydrates as an energy source, leading to improved glucose tolerance and insulin sensitivity. Enzyme-deficient male mice are fertile, whereas females lack the ability to suckle their offspring due to impaired milk production. Enzyme-deficient mice exhibit defective thermogenesis in brown adipose tissue. Enzyme-deficient macrophages accumulate triacylglycerol-rich lipid droplets resulting in altered cell morphology that resemble macrophage foam cells. ATGL deficiency attenuates the mRNA expression of the proinflammatory chemokine (C-X-C motif) ligand 1 (Gro1) and the release of interleukin-6 from macrophages. Enzyme deficiency limits adipose tissue macrophage accumulation during fasting |
729345 |
| 3.1.1.3 | malfunction |
hepatic lipase deficiency reduces body fate stores and protects against diet-induced obesity |
708339 |
| 3.1.1.3 | malfunction |
in ATGL or CGI-58 cause neutral lipid storage disease with myopathy and ichthyosis, respectively, in humans |
709424 |
| 3.1.1.3 | malfunction |
the absence of adipose triglyceride lipase has pleiotropic roles in mitochondrial function |
729337 |
| 3.1.1.3 | metabolism |
ATGL and HSl in lipolysis, overview |
709424 |
| 3.1.1.3 | metabolism |
ATGL selectively performs the first step in triacylglyceride hydrolysis resulting in the formation of diacylglyceride and free fatty acid. ATGL is important in the lipolysis, the coordinated catabolism of triacylglycerol stored in cellular lipid droplets, providing fatty acids, di-, and monoglycerides, besides the hormone sensitive lipase, and the lipid droplet binding proteins, perilipin, adipophilin, and Tip47, detailed pathway overview |
707547 |
| 3.1.1.3 | metabolism |
the enzyme facilitates triacylglycerol turnover in Chlamydomonas primarily by degrading the diacylglycerol presumably generated from triacylglycerol hydrolysis |
-, 729664 |
| 3.1.1.3 | more |
HDL particles in plasma are central to regulation of hepatic lipase displacement and the hydrolytic activity of hepatic lipase, overview |
709777 |
| 3.1.1.3 | more |
three-dimensional structure molecular modelling and dynamic light scattering measurements, sequence comparisons, overview |
-, 749967 |
