Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CGI-58 | lipid droplet-binding protein | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
triacylglycerol + H2O | Mus musculus | - |
diacylglycerol + a carboxylate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brown adipose tissue | - |
Mus musculus | - |
macrophage | - |
Mus musculus | - |
white adipose tissue | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme lacks the ability to hydrolyze monoacylglycerol, CEs, or retinyl esters | Mus musculus | ? | - |
? | |
triacylglycerol + H2O | - |
Mus musculus | diacylglycerol + a carboxylate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
adipose triglyceride lipase | - |
Mus musculus |
ATGL | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme-deficient mice show an increased utilization of carbohydrates as an energy source, leading to improved glucose tolerance and insulin sensitivity. Enzyme-deficient male mice are fertile, whereas females lack the ability to suckle their offspring due to impaired milk production. Enzyme-deficient mice exhibit defective thermogenesis in brown adipose tissue. Enzyme-deficient macrophages accumulate triacylglycerol-rich lipid droplets resulting in altered cell morphology that resemble macrophage foam cells. ATGL deficiency attenuates the mRNA expression of the proinflammatory chemokine (C-X-C motif) ligand 1 (Gro1) and the release of interleukin-6 from macrophages. Enzyme deficiency limits adipose tissue macrophage accumulation during fasting | Mus musculus |