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CTP:phosphocholine cytidylyltransferase beta2
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CDP-choline pyrophosphorylase
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CDP-choline synthetase
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choline phosphate cytidylyltransferase
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CTP-phosphocholine cytidylyltransferase
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CTP:cholinephosphate cytidylyltransferase
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CTP:phosphocholine cytidylyltransferase
CTP:phosphocholine cytidylyltransferase alpha
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CTP:phosphocholine cytidylyltransferase beta2
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CTP:phosphocholine cytidylyltransferase beta3
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CTP:phosphocholine cytidylyltransferase-alpha
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CTP:phosphocholine cytidylyltransferase-beta2
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CTP:phosphocholine cytidylyltranspherase alpha
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CTP:phosphorylcholine cytidylyltransferase
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cytidine diphosphocholine pyrophosphorylase
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cytidylyltransferase, choline phosphate
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phosphocholine cytidylyltransferase
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phosphocholine cytidylyltransferase alpha
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phosphorylcholine cytidylyltransferase
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phosphorylcholine transferase
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phosphorylcholine:CTP cytidylyltransferase
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CCT
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CCTalpha
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CCTbeta3
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CTP:phosphocholine cytidylyltransferase
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CTP:phosphocholine cytidylyltransferase
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additional information
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different isoforms, CCTalpha and CCTbeta 2 and -3, CCTbeta 1 is not found in mice
additional information
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four isoforms, CCTalpha ubiquitously expressed, whereas CCTbeta 1,-2, and -3 restricted in distribution
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Boggs, K.P.; Rock, C.O.; Jackowski, S.
Lysophosphatidylcholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine inhibit the CDP-choline pathway of phosphatidylcholine synthesis at the CTP:phosphocholine cytidylyltransferase step
J. Biol. Chem.
270
7757-7764
1995
Mus musculus
brenda
Ridsdale, R.; Tseu, I.; Wang, J.; Post, M.
CTP:phosphocholine cytidylyltransferase a is a cytosolic protein in pulmonary epithelial cells and tissues
J. Biol. Chem.
276
49148-49155
2001
Mus musculus, Rattus norvegicus
brenda
Zhou, J.; Ryan, A.J.; Medh, J.; Mallampalli, R.K.
Oxidized lipoproteins inhibit surfactant phosphatidylcholine synthesis via calpain-mediated Cleavage of CTP:phosphocholine cytidylyltransferase
J. Biol. Chem.
278
37032-37040
2003
Mus musculus, Rattus norvegicus
brenda
Ryan, A.J.; Fisher, K.; Thomas, C.P.; Mallampalli, R.K.
Transcriptional repression of the CTP:phosphocholine cytidylyltransferase gene by sphingosine
Biochem. J.
382
741-750
2004
Mus musculus, Rattus norvegicus
brenda
Ridsdale, R.; Tseu, I.; Roth-Kleiner, M.; Wang, J.; Post, M.
Increased phosphatidylcholine production but disrupted glycogen metabolism in fetal type II cells of mice that overexpress CTP:phosphocholine cytidylyltransferase
J. Biol. Chem.
279
55946-55957
2004
Mus musculus, Rattus norvegicus
brenda
Jackowski, S.; Fagone, P.
CTP:phosphocholine cytidylyltransferase: Paving the way from gene to membrane
J. Biol. Chem.
280
853-856
2005
Arabidopsis thaliana, Homo sapiens, Mus musculus
brenda
Gunter, C.; Frank, M.; Tian, Y.; Murti, K.G.; Rehg, J.E.; Jackowski, S.
Probucol therapy overcomes the reproductive defect in CTP: phosphocholine cytidylyltransferase beta2 knockout mice
Biochim. Biophys. Acta
1771
845-852
2007
Mus musculus (P49586), Mus musculus (Q811Q9)
brenda
Marcucci, H.; Elena, C.; Gilardoni, P.; Banchio, C.
Characterization of the murine CTP:phosphocholine cytidylyltransferase beta gene promoter
Biochim. Biophys. Acta
1781
254-262
2008
Mus musculus
brenda
Kacher, Y.; Golan, A.; Pewzner-Jung, Y.; Futerman, A.H.
Changes in macrophage morphology in a Gaucher disease model are dependent on CTP:phosphocholine cytidylyltransferase alpha
Blood Cells Mol. Dis.
39
124-129
2007
Homo sapiens, Mus musculus
brenda
Banchio, C.; Lingrell, S.; Vance, D.E.
Sp-1 binds promoter elements that are regulated by retinoblastoma and regulate CTP:phosphocholine cytidylyltransferase-alpha transcription
J. Biol. Chem.
282
14827-14835
2007
Mus musculus
brenda
Chen, B.B.; Mallampalli, R.K.
Calmodulin binds and stabilizes the regulatory enzyme, CTP:phosphocholine cytidylyltransferase
J. Biol. Chem.
282
33494-33506
2007
Mus musculus
brenda
Jacobs, R.L.; Lingrell, S.; Zhao, Y.; Francis, G.A.; Vance, D.E.
Hepatic CTP:phosphocholine cytidylyltransferase-alpha is a critical predictor of plasma high density lipoprotein and very low density lipoprotein
J. Biol. Chem.
283
2147-2155
2008
Mus musculus
brenda
Tian, Y.; Zhou, R.; Rehg, J.E.; Jackowski, S.
Role of phosphocholine cytidylyltransferase alpha in lung development
Mol. Cell. Biol.
27
975-982
2007
Mus musculus
brenda
Okamura, K.; Yamashita, S.; Ando, H.; Horibata, Y.; Aoyama, C.; Takagishi, K.; Izumi, T.; Vance, D.E.; Sugimoto, H.
Identification of nuclear localization and nuclear export signals in Ets2, and the transcriptional regulation of Ets2 and CTP:phosphocholine cytidylyltransferase alpha in tetradecanoyl-13-acetate or macrophage-colony stimulating factor stimulated RAW264 cells
Biochim. Biophys. Acta
1791
173-182
2009
Mus musculus
brenda
Fagone, P.; Gunter, C.; Sage, C.R.; Gunn, K.E.; Brewer, J.W.; Jackowski, S.
CTP:phosphocholine cytidylyltransferase alpha is required for B-cell proliferation and class switch recombination
J. Biol. Chem.
284
6847-6854
2009
Mus musculus
brenda
Strakova, J.; Demizieux, L.; Campenot, R.B.; Vance, D.E.; Vance, J.E.
Involvement of cin axonal phosphatidylcholine synthesis and branching of neurons
Biochim. Biophys. Acta
1811
617-625
2011
Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Krahmer, N.; Guo, Y.; Wilfling, F.; Hilger, M.; Lingrell, S.; Heger, K.; Newman, H.W.; Schmidt-Supprian, M.; Vance, D.E.; Mann, M.; Farese, R.V.; Walther, T.C.
Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase
Cell Metab.
14
504-515
2011
Drosophila melanogaster, Mus musculus
brenda
Ogasawara, Y.; Cheng, J.; Tatematsu, T.; Uchida, M.; Murase, O.; Yoshikawa, S.; Ohsaki, Y.; Fujimoto, T.
Long-term autophagy is sustained by activation of CCTbeta3 on lipid droplets
Nat. Commun.
11
4480
2020
Mus musculus
brenda