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Literature summary for 2.7.7.15 extracted from
- Sp-1 binds promoter elements that are regulated by retinoblastoma and regulate CTP:phosphocholine cytidylyltransferase-alpha transcription (2007), J. Biol. Chem., 282, 14827-14835.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| retinoblastoma protein | regulates CTalpha expression by different mechanisms depending on the phase of the cell cycle, the regulation of CTalpha expression requires both the Sp1 and the retinoblastoma control elements | Mus musculus | |
| Sp1 | Sp1 stimulates CTalpha transcription, and Sp1-mediated transcription is stimulated by the retinoblastoma protein | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| C3H10T1/2 cell | - |
Mus musculus | - |
| MEF cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + choline phosphate | - |
Mus musculus | diphosphate + CDP-choline | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CTalpha | - |
Mus musculus |
| CTP:phosphocholine cytidylyltransferase-alpha | - |
Mus musculus |
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