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Literature summary for 2.7.7.15 extracted from

  • Zhou, J.; Ryan, A.J.; Medh, J.; Mallampalli, R.K.
    Oxidized lipoproteins inhibit surfactant phosphatidylcholine synthesis via calpain-mediated Cleavage of CTP:phosphocholine cytidylyltransferase (2003), J. Biol. Chem., 278, 37032-37040.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.15

Cloned(Commentary)

Cloned (Comment) Organism
-
 Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
K238R/K239R/Y240F increased resistance to calpain cleavage, resistance to enzyme degradation by oxidized low density lipoprotein Mus musculus
additional information deletion mutant lacking the putative membrane binding domain Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
oxidized low density lipoprotein 40% inhibition by increase of enzyme degradation; 75% inhibition by increase of enzyme degradation Mus musculus
oxidized low density lipoprotein
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
alveolar cell
-
 Rattus norvegicus
-
epithelial cell
-
 Mus musculus
-
epithelial cell
-
 Rattus norvegicus
-
lung
-
 Mus musculus
-
lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + choline phosphate
-
 Mus musculus diphosphate + CDPcholine
-
 ?
CTP + choline phosphate
-
 Rattus norvegicus diphosphate + CDPcholine
-
 ?