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Literature summary for 2.7.7.15 extracted from

  • Krahmer, N.; Guo, Y.; Wilfling, F.; Hilger, M.; Lingrell, S.; Heger, K.; Newman, H.W.; Schmidt-Supprian, M.; Vance, D.E.; Mann, M.; Farese, R.V.; Walther, T.C.
    Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase (2011), Cell Metab., 14, 504-515.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information binding to the lipid droplets activates the enzyme Drosophila melanogaster
additional information binding to the lipid droplets activates the enzyme Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Drosophila melanogaster 5829
-
cytosol
-
Mus musculus 5829
-
lipid droplet CTP:phosphocholine cytidylyltransferase binds stably and via its amphipatic alpha helix to lipid droplet surface during surface expansion, which is essential for the lipid droplet. It is the only enzyme of the phosphatidylecholine synthesis Kennedy pathway that localizes in the lipid droplets Drosophila melanogaster 5811
-
lipid droplet CTP:phosphocholine cytidylyltransferase binds stably and via its amphipatic alpha helix to lipid droplet surface during surface expansion, which is essential for the lipid droplet. It is the only enzyme of the phosphatidylecholine synthesis Kennedy pathway that localizes in the lipid droplets Mus musculus 5811
-
additional information CCT1 Is mobile and shuttles between nucleus and cytosol before oleate loading. CCT1 targets to lipid droplets after an initial delay and relocalizes to the nucleus when oleate is removed. CCT1 is targeted to lipid droplets when phosphatidylcholine levels are inadequate Drosophila melanogaster
-
-
additional information CCT1 Is mobile and shuttles between nucleus and cytosol before oleate loading. CCT1 targets to lipid droplets after an initial delay and relocalizes to the nucleus when oleate is removed. CCT1 is targeted to lipid droplets when phosphatidylcholine levels are inadequate Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + phosphocholine Drosophila melanogaster
-
diphosphate + CDP-choline
-
?
CTP + phosphocholine Mus musculus
-
diphosphate + CDP-choline
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
S2 cell
-
Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + phosphocholine
-
Drosophila melanogaster diphosphate + CDP-choline
-
?
CTP + phosphocholine
-
Mus musculus diphosphate + CDP-choline
-
?

Synonyms

Synonyms Comment Organism
CCT
-
Drosophila melanogaster
CCT
-
Mus musculus
CCT1
-
Drosophila melanogaster
CCT1
-
Mus musculus
CTP:phosphocholine cytidylyltransferase
-
Drosophila melanogaster
CTP:phosphocholine cytidylyltransferase
-
Mus musculus

General Information

General Information Comment Organism
metabolism the enzyme catalyzes a step in the Kennedy pathway for phosphatidylecholine synthesis, overview Drosophila melanogaster
metabolism the enzyme catalyzes a step in the Kennedy pathway for phosphatidylecholine synthesis, overview Mus musculus
physiological function phosphatidylcholine acts as a surfactant to prevent lipid droplet coalescence, which otherwise yields large, lipolysis-resistant lipid droplets and triglyceride accumulation. The need for additional phosphatidylecholine to coat the enlarging surface during lipid droplet expansion is provided by the Kennedy pathway, which is activated by reversible targeting of the rate-limiting enzyme, CTP:phosphocholine cytidylyltransferase, to growing lipid droplet surfaces. CCT1 regulates lipid droplet size and triacylgylceride storage in vivo Drosophila melanogaster
physiological function phosphatidylcholine acts as a surfactant to prevent lipid droplet coalescence, which otherwise yields large, lipolysis-resistant lipid droplets and triglyceride accumulation. The need for additional phosphatidylecholine to coat the enlarging surface during lipid droplet expansion is provided by the Kennedy pathway, which is activated by reversible targeting of the rate-limiting enzyme, CTP:phosphocholine cytidylyltransferase, to growing lipid droplet surfaces. CCT1 regulates lipid droplet size and triacylgylceride storage in vivo Mus musculus