Any feedback?
Please rate this page
(ligand.php)
(0/150)

BRENDA support

Ligand CTP

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of CTP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H16N3O14P3
CTP
PCDQPRRSZKQHHS-XVFCMESISA-N
Synonyms:
5'-CTP, cytidine triphosphate, D-CTP
Pathway Source
Pathways
MetaCyc
alpha-dystroglycan glycosylation, C20,20 CDP-archaeol biosynthesis, C25,25 CDP-archaeol biosynthesis, CDP-4-dehydro-3,6-dideoxy-D-glucose biosynthesis, CDP-6-deoxy-D-gulose biosynthesis more


Show all pahtways known for Show all BRENDA pathways known for CTP

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (92 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cob(I)alamin + CTP + H2O + H+ = cytosylcobalamin + diphosphate + phosphate
show the reaction diagram
-
CTP + dolichol = CDP + dolichyl phosphate
show the reaction diagram
-
CTP + riboflavin = CDP + FMN
show the reaction diagram
CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
-
CTP + phytol = CDP + phytyl phosphate
show the reaction diagram
-
CTP + (R)-pantothenate = CDP + (R)-4'-phosphopantothenate
show the reaction diagram
-
CTP + N5-phospho-L-glutamine = diphosphate + N5-(cytidine 5'-diphosphoramidyl)-L-glutamine
show the reaction diagram
-
2-hydroxyethylphosphonate + CTP = cytidine 5'-[[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate] + diphosphate
show the reaction diagram
-
CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine
show the reaction diagram
CTP + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
show the reaction diagram
CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor
show the reaction diagram
-
CTP + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = diphosphate + CMP-8-amino-3,8-dideoxy-alpha-D-manno-octulosonate
show the reaction diagram
-
CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate
show the reaction diagram
-
CTP + H2O = CDP + phosphate
show the reaction diagram
CTP + H2O = CMP + diphosphate
show the reaction diagram
-
CTP = 3',5'-cyclic CMP + diphosphate
show the reaction diagram
-
CTP + H2O + polypeptide = CDP + phosphate + unfolded polypeptide
show the reaction diagram
-
CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
show the reaction diagram
-
CTP + H2O = ?
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (74 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + CDP = ADP + CTP
show the reaction diagram

Substrate in Enzyme-catalyzed Reactions (578 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CTP + formate = dCTP + CO2 + H2O
show the reaction diagram
-
CTP + reduced thioredoxin = 2'-dCTP + thioredoxin disulfide + H2O
show the reaction diagram
-
5,10-methylenetetrahydrofolate + CTP = dihydrofolate + 5-methylcytidine 5'-triphosphate
show the reaction diagram
-
dimethylallyl diphosphate + CTP = ?
show the reaction diagram
-
CTP + L-methionine + H2O = S-cytosyl-L-methionine + phosphate + diphosphate
show the reaction diagram
-
CTP + D-glucose = CDP + D-glucose 6-phosphate
show the reaction diagram
-
CTP + 5-methylthioribose = CDP + 5-methylthioribose 1-phosphate
show the reaction diagram
-
CTP + D-fructose 6-phosphate = CDP + beta-D-fructose 2,6-bisphosphate
show the reaction diagram
-
CTP + D-fructose 6-phosphate = CDP + D-fructose 1,6-bisphosphate
show the reaction diagram
-
CTP + D-gluconate = CDP + 6-phospho-D-gluconate
show the reaction diagram
-
CTP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6-)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl beta-phosphate = CDP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate
show the reaction diagram
-
CTP + D-tagatose 6-phosphate = CDP + D-tagatose 1,6-bisphosphate
show the reaction diagram
-
CTP + D-ribose = CDP + D-ribose 5-phosphate
show the reaction diagram
-
CTP + L-seryl-tRNASec = CDP + O-phospho-L-seryl-tRNASec
show the reaction diagram
-
3-deoxy-alpha-D-manno-oct-2-ulopyranosyl-(2->6)-2-deoxy-2-[[(3R)-3-hydroxypentadecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + CTP = 3-deoxy-4-O-phosphono-alpha-D-manno-oct-2-ulopyranosyl-(2->6)-2-deoxy-2-[[(3R)-3-hydroxypentadecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + CDP
show the reaction diagram
-
CTP + pantoate = CDP + 4-phosphopantoate
show the reaction diagram
-
CTP + 1-deoxy-D-xylulose = CDP + 1-deoxy-D-xylulose 5-phosphate
show the reaction diagram
-
CTP + phytol = CDP + phytyl phosphate
show the reaction diagram
-
CTP + D-glucose = CDP + D-glucose 6-phosphate
show the reaction diagram
-
CTP + adenosine = CDP + AMP
show the reaction diagram
-
cytidine + CTP = CMP + CDP
show the reaction diagram
-
CTP + (2E,6E)-farnesol = CDP + (2E,6E)-farnesyl phosphate
show the reaction diagram
-
CTP + 3'-dephospho-CoA = CDP + CoA
show the reaction diagram
-
CTP + adenosine 5-phosphosulfate = CDP + 3'-phosphoadenosine 5'-phosphosulfate
show the reaction diagram
-
CTP + riboflavin = CDP + riboflavin 5'-phosphate
show the reaction diagram
-
CTP + dihydroxyacetone = CDP + dihydroxyacetone phosphate
show the reaction diagram
-
CTP + glycerol = CDP + glycerol 3-phosphate
show the reaction diagram
-
CTP + choline = CDP + choline phosphate
show the reaction diagram
-
CTP + D-fructose = CDP + D-fructose 6-phosphate
show the reaction diagram
-
CTP + 2-dehydro-3-deoxy-D-gluconate = CDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate
show the reaction diagram
-
CTP + 5-hydroxy-2-methylpyrimidine = CDP + 2-methyl-5-phosphopyrimidine
show the reaction diagram
-
CTP + 4-methyl-5-(2-hydroxyethyl)thiazole = CDP + 4-methyl-5-(2-phosphonooxyethyl)thiazole
show the reaction diagram
-
CTP + 6-deoxy-L-galactose = CDP + 6-deoxy-L-galactose 1-phosphate
show the reaction diagram
-
CTP + D-arabinose = CDP + D-arabinose 5-phosphate
show the reaction diagram
-
CTP + D-fructose 1-phosphate = CDP + D-fructose 1,6-bisphosphate
show the reaction diagram
-
CTP + N-acetyl-D-glucosamine = CDP + N-acetyl-D-glucosamine 6-phosphate
show the reaction diagram
-
CTP + D-galactose = CDP + alpha-D-galactose 1-phosphate
show the reaction diagram
-
CTP + myo-inositol = CDP + myo-inositol 1-phosphate
show the reaction diagram
-
CTP + 1-phosphatidyl-1D-myo-inositol = CDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
show the reaction diagram
-
CTP + inosine = CDP + IMP
show the reaction diagram
-
CTP + cellobiose = CDP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
show the reaction diagram
-
CTP + NADH = CDP + NADPH
show the reaction diagram
-
CTP + geranylgeraniol = CDP + geranylgeranyl phosphate
show the reaction diagram
-
CTP + inosine = CDP + inosine 5'-phosphate
show the reaction diagram
-
CTP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = CDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
show the reaction diagram
-
CTP + acetate = CDP + acetyl phosphate
show the reaction diagram
-
CTP + isobutanoate = CDP + isobutanoyl phosphate
show the reaction diagram
-
CTP + propanoate = CDP + propanoyl phosphate
show the reaction diagram
CTP + isobutyrate = CDP + isobutyryl phosphate
show the reaction diagram
-
CTP + formate = CDP + formyl phosphate
show the reaction diagram
-
CTP + AMP = CDP + ADP
show the reaction diagram
-
CTP + CMP = CDP + CDP
show the reaction diagram
-
CTP + thiamine diphosphate = CDP + thiamine triphosphate
show the reaction diagram
-
CTP + trans-farnesyl diphosphate = ?
show the reaction diagram
-
CTP + (R,S)-5-phosphomevalonate = CDP + (R,S)-5-diphosphomevalonate
show the reaction diagram
-
CTP + CMP = CDP + CDP
show the reaction diagram
-
CTP + (2E,6E)-farnesyl phosphate = CDP + (2E,6E)-farnesyl diphosphate
show the reaction diagram
-
CTP + dTMP = CDP + dTDP
show the reaction diagram
-
CTP + UMP = CDP + UDP
show the reaction diagram
-
CTP + (phosphate)n = CDP + (phosphate)n+1
show the reaction diagram
-
CTP + D-ribose 5-phosphate = CMP + 5-phospho-alpha-D-ribose 1-diphosphate
show the reaction diagram
-
CTP + thiamine = CMP + thiamine diphosphate
show the reaction diagram
-
dATP + CTP = dAMP + cytidine 3'-diphosphate 5'-triphosphate
show the reaction diagram
-
CTP + nicotinamide ribonucleotide = diphosphate + nicotinamide cytosine dinucleotide
show the reaction diagram
-
2-hydroxyethylphosphonate + CTP = cytidine 5'-[[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate] + diphosphate
show the reaction diagram
-
CTP + (2-aminoethyl)phosphonate = diphosphate + CMP-(2-aminoethyl)phosphonate
show the reaction diagram
-
CTP + FMN = diphosphate + flavin cytidine dinucleotide
show the reaction diagram
-
CTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + CDP-N-acetyl-alpha-D-glucosamine
show the reaction diagram
-
CTP + tobramycin = diphosphate + 2''-cytosylyltobramycin
show the reaction diagram
-
CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor
show the reaction diagram
-
p-tRNAHisG73 + ATP + CTP + H2O = pCp-tRNAHisG73 + AMP + 2 diphosphate
show the reaction diagram
-
RNA + CTP = RNA+1 + diphosphate
show the reaction diagram
-
CTP + N,N'-diacetyllegionaminic acid = CMP-N,N'-diacetyllegionaminic acid + diphosphate
show the reaction diagram
-
3 CTP = ?
show the reaction diagram
-
CTP + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = diphosphate + CMP-8-amino-3,8-dideoxy-alpha-D-manno-octulosonate
show the reaction diagram
-
CTP + valienol 1-phosphate = diphosphate + CDP-valienol
show the reaction diagram
-
CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate
show the reaction diagram
-
CTP + H2O = CDP + phosphate
show the reaction diagram
-
glucose + CTP = glucose 6-phosphate + CDP
show the reaction diagram
-
CTP + H2O = CDP + phosphate
show the reaction diagram
-
CTP + H2O = CDP + phosphate
show the reaction diagram
-
CTP + H2O = ?
show the reaction diagram
-
CTP + dihydrouracil + H2O = ?
show the reaction diagram
-
CTP + H2O = ?
show the reaction diagram
-
CTP + H2O = UTP + NH3
show the reaction diagram
-
CTP + H2O = ?
show the reaction diagram
-
CTP + H2O = CMP + diphosphate
show the reaction diagram
-
CTP + H2O = CDP + phosphate
show the reaction diagram
-
CTP + H2O = ?
show the reaction diagram
-
CTP + H2O = CMP + diphosphate
show the reaction diagram
-
CTP + H2O = CMP + diphosphate
show the reaction diagram
-
CTP + H2O = CMP + diphosphate
show the reaction diagram
-
CTP + H2O = CDP + phosphate
show the reaction diagram
-
CTP + H2O = CDP + phosphate
show the reaction diagram
-
CTP + H2O = CDP + phosphate
show the reaction diagram
-
CTP + H2O = CDP + phosphate
show the reaction diagram
-
CTP + 5-diphosphomevalonate = CDP + phosphate + isopentenyl diphosphate + CO2
show the reaction diagram
-
CTP + oxaloacetate = CDP + phosphoenolpyruvate + CO2
show the reaction diagram
-
CTP = 3',5'-cyclic CMP + diphosphate
show the reaction diagram
-
CTP = 3',5'-cyclic CMP + diphosphate
show the reaction diagram
-
CTP + H2O + a dynein associated with a microtubule at position n = CDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
show the reaction diagram
-
CTP + H2O + closed Cl- channel = CDP + phosphate + open Cl- channel
show the reaction diagram
-
CTP + H2O = CDP + phosphate
show the reaction diagram
-
CTP + H2O = CDP + phosphate
show the reaction diagram
-
CTP + acetate + CoA = CMP + diphosphate + acetyl-CoA
show the reaction diagram
-
CTP + ferulate + CoA = CMP + diphosphate + feruloyl-CoA
show the reaction diagram
-
CTP + acetate + CoA = CDP + phosphate + acetyl-CoA
show the reaction diagram
-
CTP + butyrate + CoA = CMP + diphosphate + butyryl-CoA
show the reaction diagram
-
CTP + acetate + citrate (pro-3S)-lyase = CMP + diphosphate + citrate(pro-3S)-lyase
show the reaction diagram
-
CTP + phytanate + CoA = CMP + diphosphate + phytanoyl-CoA
show the reaction diagram
-
CTP + o-succinylbenzoate + CoA = CMP + diphosphate + o-succinylbenzoyl-CoA
show the reaction diagram
-
CTP + 4-hydroxybenzoate + CoA = CMP + 4-hydroxybenzoyl-CoA + diphosphate
show the reaction diagram
-
CTP + phenylacetate + CoA = CMP + diphosphate + phenylacetyl-CoA
show the reaction diagram
-
3-hydroxypropanoate + CTP + coenzyme A = 3-hydroxypropanoyl-CoA + CMP + diphosphate
show the reaction diagram
-
CTP + oxalate + CoA = CMP + diphosphate + oxalyl-CoA
show the reaction diagram
-
CTP + diphthine + ammonia = CDP + phosphate + diphthamide
show the reaction diagram
-
CTP + (R)-pantoate + beta-alanine = CMP + diphosphate + (R)-pantothenate
show the reaction diagram
-
CTP + L-His + beta-Ala = CMP + phosphate + carnosine
show the reaction diagram
-
CTP + D-Ala + membrane-acceptor = CDP + phosphate + D-alanyl-membrane acceptor
show the reaction diagram
-
CTP + 5,6,7,8-tetrahydropteroyl-Glu + Glu = CDP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu2
show the reaction diagram
-
CTP + gamma-Glu-L-Cys + Gly = CDP + phosphate + glutathione
show the reaction diagram
-
CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
show the reaction diagram
-
CTP + imidazoleacetic acid + 5-phosphoribosyl diphosphate = CDP + phosphate + 5'-phosphoribosylimidazoleacetate + diphosphate
show the reaction diagram
-
CTP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxyltransferase] = CMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxyltransferase]
show the reaction diagram
-
CTP + L-Asp + L-Gln = CMP + diphosphate + Asn + Glu
show the reaction diagram
-
ATP + CTP = P1-(5'-adenosyl),P4-(5'-cytidyl)tetraphosphate + diphosphate
show the reaction diagram
-
CTP + RNA 3'-terminal-phosphate = CMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
show the reaction diagram
-
CTP + hydrogenobyrinic acid a,c-diamide + Co2+ = CDP + phosphate + cob(II)yrinic acid a,c-diamide + H+
show the reaction diagram
-
CTP + H2O + H+/in = CDP + phosphate + H+/out
show the reaction diagram
-
CTP + H2O + Ca2+[side 1] = CDP + phosphate + Ca2+[side 2]
show the reaction diagram
-
CTP + H2O + H+/in + K+/out = CDP + phosphate + H+/out + K+/in
show the reaction diagram
-
CTP + H2O = ?
show the reaction diagram
-
CTP + H2O + phosphate/out = CDP + phosphate + phosphate/in
show the reaction diagram
-
CTP + H2O + His/out = CDP + phosphate + His/in
show the reaction diagram
-
CTP + H2O + peptide/out = CDP + phosphate + peptide/in
show the reaction diagram
-
spermidine/out + CTP + H2O = spermidine/in + CDP + phosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (198 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CDP + phosphoenolpyruvate = CTP + pyruvate
show the reaction diagram
-
CDP + phosphoramide = CTP + NH3
show the reaction diagram
-
CDP + (phosphate)n+1 = CTP + (phosphate)n
show the reaction diagram
-
diphosphate + CDP-glucose = CTP + alpha-D-glucose 1-phosphate
show the reaction diagram
diphosphate + CDP-glucose = CTP + alpha-D-glucose 1-phosphate
show the reaction diagram
-
Ap4C + H2O = AMP + CTP
show the reaction diagram
-
CDP + phosphate + acetyl-CoA = CTP + acetate + CoA
show the reaction diagram
-
CDP + phosphate + Na+/out = CTP + H2O + Na+/in
show the reaction diagram
-

Enzyme Cofactor/Cosubstrate (40 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation
-
enhances activity
-
about 40% activity compared to ATP
-
5% of the activity with ATP
-
less active than ATP
-
less active than ATP
-
low activity
can partially substitute for ATP
-
activation by nucleotides, most efficient in presence of two different nucleotides
-
activation, maintains enzyme in its active conformation at pH 5 and above
-
the enzyme shows low helicase activity in the presence of CTP (35%)
-

Activator in Enzyme-catalyzed Reactions (98 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
at 1mM concentration slight stimulation
-
marked stimulation, presence of 50 mM CTP decreases the Km value for ribulose 5-phosphate from 400 to 50 microM
-
about half as active as ATP
-