Ligand CTP

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Basic Ligand Information

Molecular Structure

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C₉H₁₆N₃O₁₄P₃

CTP

PCDQPRRSZKQHHS-XVFCMESISA-N

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Synonyms:

5'-CTP, cytidine triphosphate, D-CTP

Related pathways

BRENDA

CDP-diacylglycerol biosynthesis, chlorophyll metabolism, CMP-KDO biosynthesis, coenzyme A metabolism, dolichol and dolichyl phosphate biosynthesis

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KEGG

Biosynthesis of cofactors, Mannose type O-glycan biosynthesis, Nucleotide metabolism, Pyrimidine metabolism

MetaCyc

alpha-dystroglycan glycosylation, C20,20 CDP-archaeol biosynthesis, C25,25 CDP-archaeol biosynthesis, CDP-4-dehydro-3,6-dideoxy-D-glucose biosynthesis, CDP-6-deoxy-D-gulose biosynthesis, CDP-D-arabitol biosynthesis, CDP-D-mannitol biosynthesis, CDP-diacylglycerol biosynthesis I, CDP-diacylglycerol biosynthesis II, CDP-diacylglycerol biosynthesis III, cell-surface glycoconjugate-linked phosphocholine biosynthesis, cell-surface glycoconjugate-linked phosphonate biosynthesis, choline biosynthesis III, CMP phosphorylation, CMP-2-keto-3-deoxy-D-glycero-D-galacto-nononate biosynthesis, CMP-3-deoxy-D-manno-octulosonate biosynthesis, CMP-8-amino-3,8-dideoxy-D-manno-octulosonate biosynthesis, CMP-diacetamido-8-epilegionaminic acid biosynthesis, CMP-legionaminate biosynthesis I, CMP-legionaminate biosynthesis II, CMP-N-acetyl-7-O-acetylneuraminate biosynthesis, CMP-N-acetylneuraminate biosynthesis I (eukaryotes), CMP-N-acetylneuraminate biosynthesis II (bacteria), CMP-pseudaminate biosynthesis, coenzyme A biosynthesis I (bacteria), coenzyme A biosynthesis III (archaea), cytidine-5'-diphosphate-glycerol biosynthesis, cytidylyl molybdenum cofactor biosynthesis, di-myo-inositol phosphate biosynthesis, diacylglycerol and triacylglycerol biosynthesis, dolichol and dolichyl phosphate biosynthesis, farnesylcysteine salvage pathway, flavin biosynthesis II (archaea), fosfomycin biosynthesis, FR-900098 and FR-33289 antibiotics biosynthesis, lipid A-core biosynthesis (P. gingivalis), methylerythritol phosphate pathway I, methylerythritol phosphate pathway II, monoacylglycerol metabolism (yeast), phosalacine biosynthesis, phosphatidylcholine biosynthesis I, phosphatidylcholine biosynthesis II, phosphatidylcholine biosynthesis III, phosphatidylcholine biosynthesis IV, phosphatidylethanolamine biosynthesis II, phosphinothricin tripeptide biosynthesis, phytol salvage pathway, plasmalogen biosynthesis I (aerobic), poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis, poly(glycerol phosphate) wall teichoic acid biosynthesis, poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis), poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus), pyrimidine deoxyribonucleotides biosynthesis from CTP, pyrimidine deoxyribonucleotides de novo biosynthesis I, pyrimidine deoxyribonucleotides de novo biosynthesis II, pyrimidine deoxyribonucleotides de novo biosynthesis III, pyrimidine deoxyribonucleotides de novo biosynthesis IV, streptomycin biosynthesis, superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli), type I lipoteichoic acid biosynthesis (S. aureus), type IV lipoteichoic acid biosynthesis (S. pneumoniae), UTP and CTP de novo biosynthesis, UTP and CTP dephosphorylation I, UTP and CTP dephosphorylation II

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Show all BRENDA pathways known for CTP

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (108 results)

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2.5.1.17

cob(I)alamin + CTP + H2O + H+ = cytosylcobalamin + diphosphate + phosphate

674576

2.7.1.108

CTP + dolichol = CDP + dolichyl phosphate

640391, 640395, 640399, 640392, 640396, 640394, 640398, 640393, 640401, 640390, 671201, 696448, 739079, 739314, 761619

2.7.1.161

CTP + riboflavin = CDP + FMN

762041

5TRD, 3D-view

2.7.1.174

CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate

693092, 687738, 738595, 761456

2.7.1.182

CTP + phytol = CDP + phytyl phosphate

726159, 738766, 739296, 761622

2.7.1.33

CTP + (R)-pantothenate = CDP + (R)-4'-phosphopantothenate

759375

2.7.7.103

CTP + N5-phospho-L-glutamine = diphosphate + N5-(cytidine 5'-diphosphoramidyl)-L-glutamine

760601

2.7.7.104

2-hydroxyethylphosphonate + CTP = cytidine 5'-[[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate] + diphosphate

755682

2.7.7.14

CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine

642882, 642883, 642884, 642887, 642881, 642886, 642885, 642888, 660968, 660979, 675978, 676425, 721549, 722415

CTP + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol

692823, 643326, 760843

CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor

CTP + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = diphosphate + CMP-8-amino-3,8-dideoxy-alpha-D-manno-octulosonate

CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate

705845

3.6.1.15

CTP + H2O = CDP + phosphate

684774, 688347, 696275, 696153, 758490, 757348, 757096

CTP + H2O = CMP + diphosphate

CTP = 3',5'-cyclic CMP + diphosphate

648784, 648787, 648788, 648789, 648790, 648792, 648791

5.6.1.5

CTP + H2O + polypeptide = CDP + phosphate + unfolded polypeptide

751668

5.6.2.4

wound dsDNA + CTP + H2O = unwound ssDNA + CDP + phosphate

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

740672

7.2.2.3

CTP + H2O = ?

210276

In Vivo Product in Enzyme-catalyzed Reactions (79 results)

ATP + CDP = ADP + CTP

3FC9, 3D-view

2.7.7.41

diphosphate + CDP-diacylglycerol = CTP + phosphatidate

Substrate in Enzyme-catalyzed Reactions (605 results)

top print hide

1.1.98.6

CTP + formate = dCTP + CO2 + H2O

740665, 740656, 740670

1.17.4.1

CTP + reduced thioredoxin = 2'-dCTP + thioredoxin disulfide + H2O

5,10-methylenetetrahydrofolate + CTP = dihydrofolate + 5-methylcytidine 5'-triphosphate

441229

2.5.1.112

dimethylallyl diphosphate + CTP = ?

CTP + D-glucose = CDP + D-glucose 6-phosphate

640230, 640240, 640228, 640237, 640209, 640224, 640234, 640208, 640226, 676958, 723049, 674266, 739403, 739618

2.7.1.100

CTP + 5-methylthioribose = CDP + 5-methylthioribose 1-phosphate

640269

2.7.1.105

CTP + D-fructose 6-phosphate = CDP + beta-D-fructose 2,6-bisphosphate

CTP + D-fructose 6-phosphate = CDP + D-fructose 1,6-bisphosphate

640421, 640446, 640485, 640443, 640442, 640463, 640436, 640509, 640511, 640426, 640495, 640518, 640522, 640484, 727544

2.7.1.113

2 entries

2.7.1.12

CTP + D-gluconate = CDP + 6-phospho-D-gluconate

739515

2.7.1.130

CTP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6-)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl beta-phosphate = CDP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate

640805

2.7.1.144

CTP + D-tagatose 6-phosphate = CDP + D-tagatose 1,6-bisphosphate

CTP + D-ribose = CDP + D-ribose 5-phosphate

CTP + L-seryl-tRNASec = CDP + O-phospho-L-seryl-tRNASec

3-deoxy-alpha-D-manno-oct-2-ulopyranosyl-(2->6)-2-deoxy-2-[[(3R)-3-hydroxypentadecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + CTP = 3-deoxy-4-O-phosphono-alpha-D-manno-oct-2-ulopyranosyl-(2->6)-2-deoxy-2-[[(3R)-3-hydroxypentadecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + CDP

698707

2.7.1.169

CTP + pantoate = CDP + 4-phosphopantoate

722549

2.7.1.17

CTP + 1-deoxy-D-xylulose = CDP + 1-deoxy-D-xylulose 5-phosphate

CTP + phytol = CDP + phytyl phosphate

726159, 727856, 738766, 739296, 761622

2.7.1.2

CTP + D-glucose = CDP + D-glucose 6-phosphate

641057, 641059, 641054, 641055, 641058, 661779, 737805

2.7.1.20

CTP + adenosine = CDP + AMP

641106, 641075, 641093, 641087, 641097, 641095, 675871, 687787, 721633

2.7.1.21

2 entries

2.7.1.213

cytidine + CTP = CMP + CDP

734747, 739025

2.7.1.216

CTP + (2E,6E)-farnesol = CDP + (2E,6E)-farnesyl phosphate

CTP + 3'-dephospho-CoA = CDP + CoA

759246

2.7.1.25

CTP + adenosine 5-phosphosulfate = CDP + 3'-phosphoadenosine 5'-phosphosulfate

641213, 641211

2.7.1.26

CTP + riboflavin = CDP + riboflavin 5'-phosphate

641252

2.7.1.29

CTP + dihydroxyacetone = CDP + dihydroxyacetone phosphate

641267, 641268

2.7.1.30

CTP + glycerol = CDP + glycerol 3-phosphate

641287, 641292, 641305, 641289, 641291, 641307, 641296

2.7.1.32

CTP + choline = CDP + choline phosphate

CTP + D-fructose = CDP + D-fructose 6-phosphate

640239, 641501, 641057, 641493, 641497, 641507, 641485, 640234, 641488, 662020, 663170, 661678, 641484

2.7.1.45

CTP + 2-dehydro-3-deoxy-D-gluconate = CDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

CTP + 5-hydroxy-2-methylpyrimidine = CDP + 2-methyl-5-phosphopyrimidine

641657

2.7.1.50

CTP + 4-methyl-5-(2-hydroxyethyl)thiazole = CDP + 4-methyl-5-(2-phosphonooxyethyl)thiazole

639720, 737878

2.7.1.52

CTP + 6-deoxy-L-galactose = CDP + 6-deoxy-L-galactose 1-phosphate

641671, 641670

2.7.1.54

CTP + D-arabinose = CDP + D-arabinose 5-phosphate

636978

2.7.1.56

CTP + D-fructose 1-phosphate = CDP + D-fructose 1,6-bisphosphate

640483, 641683, 727057

2.7.1.59

CTP + N-acetyl-D-glucosamine = CDP + N-acetyl-D-glucosamine 6-phosphate

641696

2.7.1.6

CTP + D-galactose = CDP + alpha-D-galactose 1-phosphate

CTP + myo-inositol = CDP + myo-inositol 1-phosphate

636605

2.7.1.67

CTP + 1-phosphatidyl-1D-myo-inositol = CDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

CTP + inosine = CDP + IMP

CTP + cellobiose = CDP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose

642059

2.7.1.86

CTP + NADH = CDP + NADPH

642062, 657853

2.7.1.B19

CTP + geranylgeraniol = CDP + geranylgeranyl phosphate

719754

2.7.1.B20

CTP + inosine = CDP + inosine 5'-phosphate

697882

2.7.11.31

CTP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = CDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate

644959

2.7.2.1

CTP + acetate = CDP + acetyl phosphate

642189, 642184, 487537, 642176, 642172, 642179, 642183, 721949, 727804, 730304

2.7.2.14

CTP + isobutanoate = CDP + isobutanoyl phosphate

642179

2.7.2.15

CTP + propanoate = CDP + propanoyl phosphate

737742

4FWS, 3D-view

2.7.2.18

CTP + isobutyrate = CDP + isobutyryl phosphate

CTP + formate = CDP + formyl phosphate

642342

2.7.4.10

CTP + AMP = CDP + ADP

642540, 642534, 662798

2.7.4.14

CTP + CMP = CDP + CDP

645161, 645143

2.7.4.15

CTP + thiamine diphosphate = CDP + thiamine triphosphate

645169

2.7.4.18

CTP + trans-farnesyl diphosphate = ?

645172

2.7.4.2

CTP + (R,S)-5-phosphomevalonate = CDP + (R,S)-5-diphosphomevalonate

663336

2.7.4.25

CTP + CMP = CDP + CDP

CTP + (2E,6E)-farnesyl phosphate = CDP + (2E,6E)-farnesyl diphosphate

CTP + dTMP = CDP + dTDP

645201, 645203, 645196, 645189, 645191, 645198

2.7.4.B1

CTP + UMP = CDP + UDP

663751

2.7.4.B7

CTP + (phosphate)n = CDP + (phosphate)n+1

762661

2.7.6.1

CTP + D-ribose 5-phosphate = CMP + 5-phospho-alpha-D-ribose 1-diphosphate

642716, 642729, 642738, 642711, 642710, 642735, 723571, 738194

2.7.6.2

CTP + thiamine = CMP + thiamine diphosphate

642753, 642743

2.7.6.4

dATP + CTP = dAMP + cytidine 3'-diphosphate 5'-triphosphate

645215

2.7.7.1

CTP + nicotinamide ribonucleotide = diphosphate + nicotinamide cytosine dinucleotide

2-hydroxyethylphosphonate + CTP = cytidine 5'-[[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate] + diphosphate

755682

2.7.7.107

CTP + (2-aminoethyl)phosphonate = diphosphate + CMP-(2-aminoethyl)phosphonate

CTP + FMN = diphosphate + flavin cytidine dinucleotide

721625

2.7.7.23

CTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + CDP-N-acetyl-alpha-D-glucosamine

CTP + tobramycin = diphosphate + 2''-cytosylyltobramycin

CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor

709036, 709163

2.7.7.79

p-tRNAHisG73 + ATP + CTP + H2O = pCp-tRNAHisG73 + AMP + 2 diphosphate

762372

2.7.7.8

RNA + CTP = RNA+1 + diphosphate

CTP + N,N'-diacetyllegionaminic acid = CMP-N,N'-diacetyllegionaminic acid + diphosphate

3 CTP = ?

CTP + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = diphosphate + CMP-8-amino-3,8-dideoxy-alpha-D-manno-octulosonate

734255

2.7.7.91

CTP + valienol 1-phosphate = diphosphate + CDP-valienol

CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate

705845

3.1.15.1

CTP + H2O = CDP + phosphate

CTP + H2O = CDP + phosphate

682302

3.1.3.9

glucose + CTP = glucose 6-phosphate + CDP

134941, 134945

3.1.4.16

CTP + H2O = CDP + phosphate

652555

3.1.4.37

CTP + H2O = CDP + phosphate

CTP + H2O = ?

CTP + dihydrouracil + H2O = ?

CTP + H2O = ?

CTP + H2O = UTP + NH3

CTP + H2O = ?

CTP + H2O = CMP + diphosphate

722230

3.6.1.15

CTP + H2O = CDP + phosphate

656663, 669274, 667694, 684774, 688347, 696275, 696153, 758490, 757348, 757096

7W9S, 3D-view

3.6.1.28

CTP + H2O = CDP + phosphate

210008, 210020, 210007, 210017

3.6.1.41

CTP + H2O = CDP + AMP

CTP + H2O = ?

CTP + H2O = CMP + diphosphate

CTP + H2O = CMP + diphosphate

721477, 722102, 722623, 756613

3.6.1.8

CTP + H2O = CMP + diphosphate

CTP + H2O = CDP + phosphate

735052, 757521

3.6.4.B10

CTP + H2O = CDP + phosphate

728108

3.6.4.B6

CTP + H2O = CDP + phosphate

724227, 725893

3.6.5.4

CTP + H2O = CDP + phosphate

777642

4.1.1.33

CTP + 5-diphosphomevalonate = CDP + phosphate + isopentenyl diphosphate + CO2

650496, 4377, 4376

4.1.1.49

CTP + oxaloacetate = CDP + phosphoenolpyruvate + CO2

4636

4.6.1.2

CTP = 3',5'-cyclic CMP + diphosphate

729139

4.6.1.6

CTP = 3',5'-cyclic CMP + diphosphate

648784, 648787, 648788, 648789, 648790, 648791, 648792, 714199

5.6.1.2

CTP + H2O + a dynein associated with a microtubule at position n = CDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)

247009, 247038, 247007

5.6.1.5

2 entries

5.6.1.6

CTP + H2O + closed Cl- channel = CDP + phosphate + open Cl- channel

CTP + H2O = CDP + phosphate

690795, 656166, 756304

CTP + H2O = CDP + phosphate

712760

5.6.2.B4

CTP + H2O + wound DNA = CDP + phosphate + unwound DNA

775949

6.2.1.1

CTP + acetate + CoA = CMP + diphosphate + acetyl-CoA

574

6.2.1.12

CTP + ferulate + CoA = CMP + diphosphate + feruloyl-CoA

607

6.2.1.13

CTP + acetate + CoA = CDP + phosphate + acetyl-CoA

744820

6.2.1.2

CTP + butyrate + CoA = CMP + diphosphate + butyryl-CoA

677

6.2.1.22

CTP + acetate + citrate (pro-3S)-lyase = CMP + diphosphate + citrate(pro-3S)-lyase

697

6.2.1.24

CTP + phytanate + CoA = CMP + diphosphate + phytanoyl-CoA

702

6.2.1.26

CTP + o-succinylbenzoate + CoA = CMP + diphosphate + o-succinylbenzoyl-CoA

648943

6.2.1.27

CTP + 4-hydroxybenzoate + CoA = CMP + 4-hydroxybenzoyl-CoA + diphosphate

648909

6.2.1.30

CTP + phenylacetate + CoA = CMP + diphosphate + phenylacetyl-CoA

648914

6.2.1.36

3-hydroxypropanoate + CTP + coenzyme A = 3-hydroxypropanoyl-CoA + CMP + diphosphate

692841

6.2.1.8

CTP + oxalate + CoA = CMP + diphosphate + oxalyl-CoA

847

6.3.1.14

CTP + diphthine + ammonia = CDP + phosphate + diphthamide

1162

6.3.2.1

CTP + (R)-pantoate + beta-alanine = CMP + diphosphate + (R)-pantothenate

978

6.3.2.11

CTP + L-His + beta-Ala = CMP + phosphate + carnosine

997

6.3.2.16

CTP + D-Ala + membrane-acceptor = CDP + phosphate + D-alanyl-membrane acceptor

1056

6.3.2.17

CTP + 5,6,7,8-tetrahydropteroyl-Glu + Glu = CDP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu2

1078, 1009

6.3.2.2

CTP + L-glutamate + L-cysteine = CDP + phosphate + gamma-L-glutamyl-L-cysteine

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

740672, 702284, 702454, 648958, 740570

CTP + imidazoleacetic acid + 5-phosphoribosyl diphosphate = CDP + phosphate + 5'-phosphoribosylimidazoleacetate + diphosphate

1618

6.3.4.9

CTP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxyltransferase] = CMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxyltransferase]

1619

6.3.5.4

CTP + L-Asp + L-Gln = CMP + diphosphate + Asn + Glu

1702

6.5.1.1

ATP + CTP = P1-(5'-adenosyl),P4-(5'-cytidyl)tetraphosphate + diphosphate

722217

6.5.1.4

CTP + RNA 3'-terminal-phosphate = CMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate

CTP + hydrogenobyrinic acid a,c-diamide + Co2+ = CDP + phosphate + cob(II)yrinic acid a,c-diamide + H+

653078

7.1.2.2

CTP + H2O + H+/in = CDP + phosphate + H+/out

210238, 210252, 210241

7.2.2.1

2 entries

7.2.2.10

CTP + H2O + Ca2+[side 1] = CDP + phosphate + Ca2+[side 2]

735233

7.2.2.19

CTP + H2O + H+/in + K+/out = CDP + phosphate + H+/out + K+/in

246851, 246853, 711012

7.2.2.3

CTP + H2O = ?

210276

7.3.2.1

CTP + H2O + phosphate/out = CDP + phosphate + phosphate/in

659162

7.4.2.1

CTP + H2O + His/out = CDP + phosphate + His/in

246888

7.4.2.5

CTP + H2O + peptide/out = CDP + phosphate + peptide/in

656145

7.6.2.11

spermidine/out + CTP + H2O = spermidine/in + CDP + phosphate

CTP + H2O + (leukotriene C4)glutathione[side 1] = CDP + phosphate + (leukotriene C4)glutathione[side 2]

767406

Product in Enzyme-catalyzed Reactions (203 results)

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2.7.1.40

CDP + phosphoenolpyruvate = CTP + pyruvate

2.7.3.8

CDP + phosphoramide = CTP + NH3

CDP + (phosphate)n+1 = CTP + (phosphate)n

2.7.7.33

diphosphate + CDP-glucose = CTP + alpha-D-glucose 1-phosphate

1WVC, 3D-view

2.7.7.41

diphosphate + CDP-diacylglycerol = CTP + phosphatidate

diphosphate + CDP-glucose = CTP + alpha-D-glucose 1-phosphate

643748, 643751, 643752, -

3.6.1.29

Ap4C + H2O = AMP + CTP

6.2.1.13

CDP + phosphate + acetyl-CoA = CTP + acetate + CoA

CDP + phosphate + Na+/out = CTP + H2O + Na+/in

Enzyme Cofactor/Cosubstrate (50 results)

activation

enhances activity

about 40% activity compared to ATP

738766, 739296, 761622

2.7.1.2

5% of the activity with ATP

less active than ATP

less active than ATP

low activity

642004, 642006, 642021, 642022

642266, 642256, 642268

2.7.6.1

can partially substitute for ATP

activation by nucleotides, most efficient in presence of two different nucleotides

activation, maintains enzyme in its active conformation at pH 5 and above

the activity is energy-dependent and requires Mg2+-dependent hydrolysis of CTP. The function of CTP hydrolysis remains unclear. Perhaps the nickel is brought into close proximity to the pyridinium-3,5-bisthiocarboxylate mononucleotide through a CTP-dependent conformational change

767080

5.6.2.3

CTP is somewhat less active as cofactor compared to ATP

can partly substitute for ATP

Activator in Enzyme-catalyzed Reactions (99 results)

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1.1.1.189

at 1mM concentration slight stimulation

389477

1.1.1.405

marked stimulation, presence of 50 mM CTP decreases the Km value for ribulose 5-phosphate from 400 to 50 microM

645253

1.13.11.34

about half as active as ATP

10 mM, 340% arsenolytic cleavage activity

0.67 mM, 2.5fold stimulation

637870

2.7.1.113

activation, with ATP as substrate at pH 7

the activity of the enzyme reaches its maximal activity at a CTP concentration of about 1.4 mM. The maximal activity decreases by 68 and 95% when the concentration of CTP is 5.7 and 11.4 mM, respectively

activates

less effective than ATP

133998

3.1.2.1

counteracts the inhibition of the cold-labile cytosolic enzyme by ADP

activation

activates enzyme from mesenteric lymph nodes

2 mM, activation to about 110% of control without detergent. Activation to about 200% of control in presence of 1% Triton X-100

655403

Inhibitor in Enzyme-catalyzed Reactions (664 results)

1 mM, 73% and 71% inhibition of liver and spinal cord enzyme respectively

16% inhibition

9% inhibition at 25 mM and 21% inhibition at 50 mM

391438

1.4.1.B2

about half as effective as ATP

696177

1.5.1.2

91% inactivation at 1 mM reversible with Mg2+

392125

1.6.1.1

5 mM, 86% inhibition of NADP+ reduction

3 mM, complete inhibition of rat liver and human brain transglutaminase, reversible, non-competitive to putrescine

poor

slight inhibition

no inhibition of UGT by other cytosine-related nucleotides but CTP

weak inhibition

slight

1 mM, 27% inhibition

8% residual activity at 10 mg/ml

most potent inhibitor among cytidine nucleotides

in the presence of ATP

enzymatic activity is regulated by CTP which strongly binds the enzyme at a site overlapping that of the leading substrate, dephosphocoenzyme A, thereby obscuring the binding site and limiting catalysis. 16% residual activity at 1 mM CTP

above 1 mM

4.9 mM, 30% inhibition in presence of ATP

641672

2.7.1.56

if concentration exceeds Mg2+ concentration

more than 90% inhibition at 0.3 mM

50% inhibition at 0.25 mM, inhibition can be reversed by 2 mM Mg2+

competitive to ATP

inhibits reaction with ATP and UMP, CMP or dCMP

no influence

at concentrations exceeding that of Mg2+

642881

4XSV, 3D-view

2.7.7.19

642938, 642953, 642981

inhibits uridylyl removing activity

2 mM, 13% inhibition

excess concentration causes slight inhibition

50% inhibition at 250 mM; inhibition is completely reversed by Mg2+

more effective inhibitor than GTP

646429

3.1.3.89

0.2 mM, 29% residual activity

656266

3.1.3.99

86% residual activity at 2.5 mM

735628

3.1.4.1

inhibition in decreasing order: alpha,beta-methylene-adenosine triphosphate, ATP, UTP, GTP, CTP

649302

3.1.4.40

84% inhibition at 0.86 mM

135474

3.2.1.26

inhibition of neutral invertase, no inhibition of alkaline invertase

competitive

55% inhibition at concentration of 0.066 mM

209949

3.6.1.5

free substrate inhibition

700083

3.6.1.9

potent inhibition at 0.1 mM

0.2 mM, 15% inhibition

potent inhibitor, 75fold inhibition at 10 mM

746604

4.3.1.1

allosteric inhibition, moderate decrease in activity

34813, 663989, 682024

94% and 89% inhibition of RNA and DNA helicase activity at 2.5 mM, respectively

769158

5.6.2.5

94% and 89% inhibition of RNA and DNA helicase activity at 2.5 mM, respectively

less than 40% residual activity at 20 mM

slight

in presence of ATP

2 mM, 18% inhibition of single-turnover ligation

662041

7.1.3.1

more than 80% inhibition at 2 mM

748137

3D Structure of Enzyme-Ligand-Complex (PDB) (524 results)

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (169 results)

1.61

30°C, pH 8.0

676958

2.7.1.113

2.25

pH 8.5, 37°C, recombinant enzyme, with 2'-deoxyguanosine as acceptor substrate

640561

2.7.1.169

0.47

pH 7.5, 42°C

1.5

0.62

pH 7.6, 37°C, recombinant enzyme

pH 7.5, 25°C

0.095

pH 8.0, 25°C

0.43

incubation 30 min at 30 °C

8.92

pH 6.5, 30°C

0.000914

pH 8.0, 37°C

1.02

pH 7.5, 25°C

3.36

+/- 0.17

652555

3.1.4.37

3.36

+/- 0.17

652555

3.4.24.B17

0.32

pH 8.0, 37°C

650184

3.6.1.1

94.2

at pH 9.5 and 95°C

734503

3.6.1.12

0.31

pH 8.0, 30°C

0.065

pH 8, 25°C

13.9

pH 6.6, 25°C

2.9

at pH 7.6 and 37°C

702284

6.3.3.3

5 entries

K_M Value (389 results)

0.34

pH 7.5, 42°C

722549

2.7.1.2

0.56

30°C, pH 7

0.59

pH 8

0.515

1.759

0.8

pH 10, 37°C

pH 7.5, 25°C

0.0013

cosubstrate 2'-deoxycytidine, 37°C, pH 7.4

0.025

0.759

pH 7.9, 25°C, cosubstrate NADH

226

pH 7.5, 25°C

737742

2.7.4.10

9.1

pH 8.0, with of AMP

0.116

pH 7.6, 37ºC, isoenzyme 3

642738

2.7.6.2

7.6

pH 8.1, 37°C

642753

2.7.7.103

0.17

pH 8.0, 25°C

0.48

apparent value, in 35 mM TES (K+) buffer (pH 7.2) containing 14 mM dithiothreitol, 7 mM MgCl+, at 70°C

0.055

pH 8.0, 37°C

739636

2.7.7.6

0.143

0.18

wild-type enzyme

3.1

microsomal enzyme suspension

134941, 134945

3.1.4.16

0.13

+/- 0.01

652555

3.1.4.37

0.13

+/- 0.01

652555

3.4.24.B17

0.104

pH 8.0, 37°C

650184

3.6.1.1

3.61

at pH 9.5 and 95°C

734503

3.6.1.12

0.529

pH 8.0, 30°C

2.1955

pH 8, 25°C

776049

3.6.1.5

0.148

pH 7.5, 37°C, presence of Mg2+

0.47

0.11

pH 7.6, 25°C

654976

5.6.2.3

0.47

pH 6.6, 25°C

0.13

at 37 °C, pH 7.5

659162

7.6.2.2

1.62

at pH 9.5 and 30°C

768031

K_i Value (23 results)

0.00022

pH and temperature not specified in the publication

636800

2.7.1.107

0.48

pH 7.5, 25°C

1.68

pH 7.8, 28°C

641804

2.7.2.2

4.4

plus Mg2+, 30°C, pH 5.0

19.6

wild type enzyme, pH 6.5, 23°C

661089

2.7.8.11

1.8

pH 9.0, 37°C

645311

3.5.3.6

0.11

at pH 6.0 and 50Â°C

0.074

pH 7.6, 37°C

IC₅₀ Value (17 results)

0.00000003463

at 37°C, pH not specified in the publication

739129

2.7.7.48

0.0015

IC50: 0.0015 mM

References & Links

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Show Reference (1182 entries)

Links to other databases for CTP

Ligand CTP

Basic Ligand Information

Related pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (108 results)

In Vivo Product in Enzyme-catalyzed Reactions (79 results)

Substrate in Enzyme-catalyzed Reactions (605 results)

Product in Enzyme-catalyzed Reactions (203 results)

Enzyme Cofactor/Cosubstrate (50 results)

Activator in Enzyme-catalyzed Reactions (99 results)

Inhibitor in Enzyme-catalyzed Reactions (664 results)

3D Structure of Enzyme-Ligand-Complex (PDB) (524 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (169 results)

KM Value (389 results)

Ki Value (23 results)

IC50 Value (17 results)

References & Links

Literature References (1182)

Links to other databases for CTP

k_cat Value (Turnover Number) (169 results)

K_M Value (389 results)

K_i Value (23 results)

IC₅₀ Value (17 results)