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Information on EC - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

for references in articles please use BRENDA:EC2.7.6.3
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IUBMB Comments
Binds 2 Mg2+ ions that are essential for activity . The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). The enzyme exists in varying types of multifunctional proteins in different organisms. The enzyme from the bacterium Streptococcus pneumoniae also harbours the activity of EC, dihydroneopterin aldolase , the enzyme from the plant Arabidopsis thaliana harbours the activity of EC, dihydropteroate synthase , while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with both of the two above mentioned activities .
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The enzyme appears in viruses and cellular organisms
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase, 6-hydroxy-7,8-dihydropterin pyrophosphokinase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK), 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydroxypterin pyrophosphokinase/7,8-dihydropteroate synthase, 6-hydroxymethylpterin pyrophosphokinase, more
ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate
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