Information on EC 2.7.6.3 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

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IUBMB Comments
Binds 2 Mg2+ ions that are essential for activity . The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants, fungi, and some archaeal species, including the haloarchaea) and methanopterin (in some archaeal species such as the Archaeoglobi and Methanobacteria). The enzyme exists in varying types of multifunctional proteins in different organisms. The enzyme from the bacterium Streptococcus pneumoniae also harbours the activity of EC 4.1.2.25, dihydroneopterin aldolase , the enzyme from the plant Arabidopsis thaliana harbours the activity of EC 2.5.1.15, dihydropteroate synthase , while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with both of the two above mentioned activities .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (hppk), 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, cythppk/dhps, fthppk-dhps, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, hydroxymethyldihydropterin pyrophosphokinase (hppk), hppk/dhps, dihydropterin pyrophosphokinase, 7,8-dihydroxymethylpterin-pyrophosphokinase, mithppk/dhps, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate
show the reaction diagram
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