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Ligand (7,8-dihydropterin-6-yl)methyl diphosphate

Basic Ligand Information

Molecular Structure

Related pathways

Pathway Source

Pathways

BRENDA

6-hydroxymethyl-dihydropterin diphosphate biosynthesis, tetrahydrofolate metabolism

KEGG

Biosynthesis of cofactors, Folate biosynthesis

MetaCyc

6-hydroxymethyl-dihydropterin diphosphate biosynthesis I, 6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus), 6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia), 6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium), 6-hydroxymethyl-dihydropterin diphosphate biosynthesis V (Pyrococcus), tetrahydrofolate biosynthesis I, tetrahydrofolate biosynthesis II more

Show all BRENDA pathways known for (7,8-dihydropterin-6-yl)methyl diphosphate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (9 results)

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Show Natural Substrate (9 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.5.1.105

(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aniline 5'-phosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphate

720527

-

2.5.1.15

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + 7,8-dihydropteroate

721948, 723522, 721829, 722063, 723771

1aj2, 3D-view

2.5.1.15

4-aminobenzoate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = diphosphate + 7,8-dihydropteroate

691734

1aj2, 3D-view

2.5.1.15

(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate

759184

1aj2, 3D-view

2.5.1.15

(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + 7,8-dihydropteroate

738959, 737323, 738758, 738387, 758910, 758651, 759490, 759659, 759674, 759889, 776522, 778088

1aj2, 3D-view

2.5.1.15

2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + 7,8-dihydropteroate

639666, 1022, 5108, 639670, 639675, 1014, 639674, 639684, 639679, 639673, 639681, 672544, 674784, 671349, 671272, 673141, 675731, 671366, 675117, 671307, 674331

1aj2, 3D-view

2.5.1.15

2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoylglutamate = diphosphate + dihydrofolate

1022

1aj2, 3D-view

2.5.1.15

2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + sulfamethoxazole = diphosphate + dihydropterin-sulfamethoxazole

1014

1aj2, 3D-view

2.5.1.15

6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + 7,8-dihydropteroate

759069, 759490

1aj2, 3D-view

2.5.1.15

8 entries

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

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Show Natural Product (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.6.3

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate

-

-

2.7.6.3

ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + (7,8-dihydropterin-6-yl)methyl diphosphate

-

-

2.7.6.3

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine

-

-

2.7.6.3

6-hydroxymethyl-7,8-dihydropterin + ATP = 6-hydroxymethyl-7,8-dihydropterin diphosphate + AMP

-

-

2.7.6.3

6-hydroxymethyl-7,8-dihydropterin + MgATP2- = 6-hydroxymethyl-7,8-dihydropterin diphosphate + MgAMP

-

-

2.7.6.3

5 entries

Substrate in Enzyme-catalyzed Reactions (21 results)

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Show Substrate (21 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.5.1.105

(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aniline 5'-phosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphate

720527

-

2.5.1.105

6-hydroxymethyl-7,8-dihydropterin diphosphate + 1-(4-aminophenyl)-1-deoxy-D-ribitol = 7,8-dihydropterin-6-methyl-1-(4-aminophenyl)-1-deoxy-D-ribitol + diphosphate

720527

-

2.5.1.15

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + 7,8-dihydropteroate

705600, 721948, 723522, 721829, 722063, 723771

1aj2, 3D-view

2.5.1.15

4-aminobenzoate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = diphosphate + 7,8-dihydropteroate

691734

1aj2, 3D-view

2.5.1.15

(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate

759184

1aj2, 3D-view

2.5.1.15

(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + 7,8-dihydropteroate

738959, 737323, 738758, 738387, 639678, 758910, 758651, 759490, 759659, 759674, 759889, 776522, 778088

1aj2, 3D-view

2.5.1.15

2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + 7,8-dihydropteroate

1014, 639665, 639666, 639676, 1022, 639679, 639673, 639667, 5108, 639668, 639670, 639671, 639680, 639681, 639675, 639674, 639684, 672544, 674784, 671349, 671272, 673141, 675731, 671366, 675117, 671307, 674331

1aj2, 3D-view

2.5.1.15

2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoylglutamate = diphosphate + dihydrofolate

1022

1aj2, 3D-view

2.5.1.15

2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + sulfamethoxazole = diphosphate + dihydropterin-sulfamethoxazole

1014

1aj2, 3D-view

2.5.1.15

2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + sulfanilamide = diphosphate + dihydropterin-sulfanilamide

1014

1aj2, 3D-view

2.5.1.15

2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + sulfathiazole = diphosphate + dihydropterin-sulfathiazole

1014

1aj2, 3D-view

2.5.1.15

6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + 7,8-dihydropteroate

691070, 759069, 759490

1aj2, 3D-view

2.5.1.15

p-aminobenzoic acid + 6-hydroxymethyl-7,8-dihydropterin diphosphate = diphosphate + 7,8-dihydropteroate

690820

1aj2, 3D-view

2.5.1.15

sulfadiazine + 6-hydroxymethyl-7,8-dihydropterin diphosphate = diphosphate + 4-[[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino]-N-pyrimidin-2-ylbenzenesulfonamide

691070

1aj2, 3D-view

2.5.1.15

sulfamethizole + 6-hydroxymethyl-7,8-dihydropterin diphosphate = ?

691070

1aj2, 3D-view

2.5.1.15

sulfamethizole + 6-hydroxymethyl-7,8-dihydropterin diphosphate = diphosphate + 4-[[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino]-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide

691070

1aj2, 3D-view

2.5.1.15

sulfamethoxazole + 6-hydroxymethyl-7,8-dihydropterin diphosphate = diphosphate + 4-[[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino]-N-(5-methylisoxazol-3-yl)benzenesulfonamide

691070

1aj2, 3D-view

2.5.1.15

sulfanilamide + 6-hydroxymethyl-7,8-dihydropterin diphosphate = diphosphate + 4-[[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino]benzenesulfonamide

691070

1aj2, 3D-view

2.5.1.15

sulfathiazole + 6-hydroxymethyl-7,8-dihydropterin diphosphate = diphosphate + 4-[[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino]-N-1,3-thiazol-2-ylbenzenesulfonamide

691070

1aj2, 3D-view

2.5.1.15

sulfisoxazole + 6-hydroxymethyl-7,8-dihydropterin diphosphate = ?

691070

1aj2, 3D-view

2.5.1.15

p-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin-diphosphate = diphosphate + 7,8-dihydropteroate

692394

1aj2, 3D-view

2.5.1.105

2 entries

2.5.1.15

19 entries

Product in Enzyme-catalyzed Reactions (7 results)

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Show Product (7 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.6.3

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate

-

-

2.7.6.3

ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + (7,8-dihydropterin-6-yl)methyl diphosphate

-

-

2.7.6.3

ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + H+ + (7,8-dihydropterin-6-yl)methyl diphosphate

-

-

2.7.6.3

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine

-

-

2.7.6.3

dATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = dAMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine

-

-

2.7.6.3

6-hydroxymethyl-7,8-dihydropterin + ATP = 6-hydroxymethyl-7,8-dihydropterin diphosphate + AMP

-

-

2.7.6.3

6-hydroxymethyl-7,8-dihydropterin + MgATP2- = 6-hydroxymethyl-7,8-dihydropterin diphosphate + MgAMP

-

-

2.7.6.3

7 entries

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.6.3

competitive inhibitor of ATP, mixed type inhibitor of 6-hydroxymethyl-7,8-dihydropteridine

639684

-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

2.5.1.15

1aj2, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (9 results)

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Show Turnover Number (9 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.5.1.15

0.0024

-

wild-type enzyme, pH 9.0, 37°C

758651

2.5.1.15

0.0029

-

mutant enzyme V585A, pH 9.0, 37°C

758651

2.5.1.15

0.0055

-

mutant enzyme A383G, pH 9.0, 37°C

758651

2.5.1.15

0.006

-

mutant enzyme S382A/A383G/A553G, pH 9.0, 37°C

758651

2.5.1.15

0.0134

-

mutant enzyme A383G/A553G, pH 9.0, 37°C

758651

2.5.1.15

0.032

-

mutant DELTA74-80

705600

2.5.1.15

0.035

-

mutant DELTA257-306

705600

2.5.1.15

0.068

-

mutant DELTA247-306

705600

2.5.1.15

0.069

-

wild type

705600

2.5.1.15

9 entries

K_M Value (8 results)

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Show KM Value (8 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.5.1.15

0.0014

-

-

639667

2.5.1.15

0.0019

-

-

639671

2.5.1.15

0.0027

-

100 microM 4-aminobenzoate, 25 °C

691070

2.5.1.15

0.0036

-

mutant DELTA257-306

705600

2.5.1.15

0.0063

-

mutant DELTA247-306

705600

2.5.1.15

0.0148

-

wild type

705600

2.5.1.15

0.03

-

-

639674

2.5.1.15

0.0514

-

mutant DELTA74-80

705600

2.5.1.15

8 entries

K_i Value (2 results)

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Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.6.3

0.005

-

versus ATP

639684

2.7.6.3

0.013

-

versus 6-hydroxymethyl-7,8-dihydropteridine

639684

2.7.6.3

2 entries

References & Links

Literature References (59)

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Show Reference (59 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

1014

385600

The characteristics and significance of sulfonamides as substrates for Escherichia coli dihydropteroate synthase

1979

Roland, S.; Ferone, R.; Harvey, R.J.; Styles, V.L.; Morrison, R.W.

J. Biol. Chem.

254

10337-10345

1022

4312465

The enzymatic synthesis of hydroxymethyldihydropteridine pyrophosphate and dihydrofolate

1969

Shiota, T.; Baugh, C.M.; Jackson, R.; Dillard, R.

Biochemistry

8

5022-5028

5108

8397083

The multifunctional folic acid synthesis fas gene of Pneumocystis carinii encodes dihydroneopterin aldolase, hydroxymethyldihydropterin pyrophosphokinase and dihydropteroate synthase

1993

Volpe, F.; Ballantine, S.P.; Delves, C.J.

Eur. J. Biochem.

216

449-458

639665

4304228

The biosynthesis of folic acid. IX. Purification and properties of the enzymes required for the formation of dihydropteroic acid

1969

Richey, D.P.; Brown, G.M.

J. Biol. Chem.

244

1582-1592

639666

-

Hydroxymethyldihydropteridine pyrophosphokinase and dihydropteroate synthetase from Escherichia coli

1971

Richey, D.P.; Brown, G.M.

Methods Enzymol.

18B

765-771

639667

4602912

Dihydropteroate synthetase from Plasmodium berghei: isolation, properties, and inhibition by dapsone and sulfadiazine

1974

McCullough, J.L.; Maren, T.H.

Mol. Pharmacol.

10

140-145

639668

4435732

Biosynthesis of folic acid compounds in plasmodia. Purification and properties of the 7,8-dihydropteroate-synthesizing enzyme from Plasmodium chabaudi

1974

Walter, R.D.; Königk, E.

Hoppe-Seyler's Z. Physiol. Chem.

355

431-437

639670

7374502

7,8-Dihydropteroate-synthesizing enzyme from Plasmodium chabaudi

1980

Walter, R.D.; Königk, E.

Methods Enzymol.

66

564-570

639671

1657875

Purification and partial characterization of 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase and 7,8-dihydropteroate synthase from Escherichia coli MC4100

1991

Talarico, T.L.; Dev, I.K.; Dallas, W.S.; Ferone, R.; Ray, P.H.

J. Bacteriol.

173

7029-7032

639673

9391132

Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum

1997

Triglia, T.; Menting, J.G.T.; Wilson, C.; Cowman, A.F.

Proc. Natl. Acad. Sci. USA

94

13944-13949

639674

9118956

Folate biosynthesis in higher plants: purification and molecular cloning of a bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/7,8-dihydropteroate synthase localized in mitochondria

1997

Rebeille, F.; Macherel, D.; Mouillon, J.M.; Garin, J.; Douce, R.

EMBO J.

16

947-957

639675

9149138

Structure and function of the dihydropteroate synthase from Staphylococcus aureus

1997

Hampele, I.C.; D'Arcy, A.; Dale, G.E.; Kostrewa, D.; Nielsen, J.; Oefner, C.; Page, M.G.P.; Schonfeld, H.J.; Stuber, D.; Then, R.L.

J. Mol. Biol.

268

21-30

639676

9650994

Characterization of a mutationally altered dihydropteroate synthase contributing to sulfathiazole resistance in Escherichia coli

1998

Vedantam, G.; Nichols, B.P.

Microb. Drug Resist.

4

91-97

639678

10471557

Sulfonamide resistance in clinical isolates of Campylobacter jejuni: mutational changes in the chromosomal dihydropteroate synthase

1999

Gibreel, A.; Skold, O.

Antimicrob. Agents Chemother.

43

2156-2160

639679

10329458

Dihydropteroate synthase from Streptococcus pneumoniae: characterization of substrate binding order and sulfonamide inhibition

1999

Vinnicombe, H.G.; Derrick, J.P.

Biochem. Biophys. Res. Commun.

258

752-757

639680

10542185

Cloning and expression of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase in Escherichia coli

1999

Nopponpunth, V.; Sirawaraporn, W.; Greene, P.J.; Santi, D.V.

J. Bacteriol.

181

6814-6821

639681

10817704

Dihydropteroate synthase of Mycobacterium leprae and dapsone resistance

2000

Williams, D.L.; Spring, L.; Harris, E.; Roche, P.; Gillis, T.P.

Antimicrob. Agents Chemother.

44

1530-1537

639684

11931659

Folate synthesis in higher-plant mitochondria: coupling between the dihydropterin pyrophosphokinase and the dihydropteroate synthase activities

2002

Mouillon, J.M.; Ravanel, S.; Douce, R.; Rebeille, F.

Biochem. J.

363

313-319

671272

17038682

Amino acid mutations in Plasmodium vivax DHFR and DHPS from several geographical regions and susceptibility to antifolate drugs

2006

Auliff, A.; Wilson, D.W.; Russell, B.; Gao, Q.; Chen, N.; Anh le, N.; Maguire, J.; Bell, D.; O'Neil, M.T.; Cheng, Q.

Am. J. Trop. Med. Hyg.

75

617-621

671307

17134675

A rapid assay for dihydropteroate synthase activity suitable for identification of inhibitors

2007

Fernley, R.T.; Iliades, P.; Macreadie, I.

Anal. Biochem.

360

227-234

671349

17316496

Sulfadoxine-pyrimethamine susceptibilities and analysis of the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum isolates from Cote d'Ivoire

2007

Djaman, J.A.; Mazabraud, A.; Basco, L.

Ann. Trop. Med. Parasitol.

101

103-112

671366

15673759

Mutations in the Pneumocystis jirovecii DHPS gene confer cross-resistance to sulfa drugs

2005

Iliades, P.; Meshnick, S.R.; Macreadie, I.G.

Antimicrob. Agents Chemother.

49

741-748

672544

16517168

Elucidation of sulfadoxine resistance with structural models of the bifunctional Plasmodium falciparum dihydropterin pyrophosphokinase-dihydropteroate synthase

2006

de Beer, T.A.; Louw, A.I.; Joubert, F.

Bioorg. Med. Chem.

14

4433-4443

673141

16355335

Dihydropteroate synthase mutations in the folP1 gene predict dapsone resistance in relapsed cases of leprosy

2006

Cambau, E.; Carthagena, L.; Chauffour, A.; Ji, B.; Jarlier, V.

Clin. Infect. Dis.

42

238-241

674331

17416665

Characterization of a novel bifunctional dihydropteroate synthase/dihydropteroate reductase enzyme from Helicobacter pylori

2007

Levin, I.; Mevarech, M.; Palfey, B.A.

J. Bacteriol.

189

4062-4069

674784

17289662

Cytosolic hydroxymethyldihydropterin pyrophosphokinase/dihydropteroate synthase from Arabidopsis thaliana: a specific role in early development and stress response

2007

Storozhenko, S.; Navarrete, O.; Ravanel, S.; De Brouwer, V.; Chaerle, P.; Zhang, G.F.; Bastien, O.; Lambert, W.; Rebeille, F.; Van Der Straeten, D.

J. Biol. Chem.

282

10749-10761

675117

16872298

Absence of dihydropteroate synthase mutations in Pneumocystis jirovecii from Brazilian AIDS patients

2006

Wissmann, G.; Alvarez-Martinez, M.J.; Meshnick, S.R.; Dihel, A.R.; Prolla, J.C.

J. Eukaryot. Microbiol.

53

305-307

675731

15892739

Identification of sulI allele of dihydropteroate synthase by representational difference analysis in Haemophilus parasuis serovar 2

2005

Del Rio, M.L.; Navas-Mendez, J.; Gutierrez-Martin, C.B.; Rodriguez-Barbosa, J.I.; Rodriguez-Ferri, E.F.

Lett. Appl. Microbiol.

40

436-442

690820

18321242

Dihydropteroate synthase from Streptococcus pneumoniae: structure, ligand recognition and mechanism of sulfonamide resistance

2008

Levy, C.; Minnis, D.; Derrick, J.P.

Biochem. J.

412

379-388

691070

18342015

Examination of intrinsic sulfonamide resistance in Bacillus anthracis: a novel assay for dihydropteroate synthase

2008

Valderas, M.W.; Andi, B.; Barrow, W.W.; Cook, P.F.

Biochim. Biophys. Acta

1780

848-853

691734

18482337

Structure-based design of a potent and selective small peptide inhibitor of Mycobacterium tuberculosis 6-hydroxymethyl-7, 8-dihydropteroate synthase: a computer modelling approach

2008

Rao, G.S.; Kumar, M.

Chem. Biol. Drug Des.

71

540-545

692394

18680522

Biochemical and structural characterization of the putative dihydropteroate synthase ortholog Rv1207 of Mycobacterium tuberculosis

2008

Gengenbacher, M.; Xu, T.; Niyomrattanakit, P.; Spraggon, G.; Dick, T.

FEMS Microbiol. Lett.

287

128-135

705600

19631695

Probing the roles of non-homologous insertions in the N-terminal domain of Plasmodium falciparum hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase

2009

Rattanachuen, W.; Joensson, M.; Swedberg, G.; Sirawaraporn, W.

Mol. Biochem. Parasitol.

168

135-142

720527

10426953

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Links to other databases for (7,8-dihydropterin-6-yl)methyl diphosphate

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